scholarly journals Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis

Cell Research ◽  
2013 ◽  
Vol 23 (4) ◽  
pp. 573-576 ◽  
Author(s):  
Zhao Zhang ◽  
Xiangdong Lv ◽  
Jin Jiang ◽  
Lei Zhang ◽  
Yun Zhao
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Somatic Stem Cell ◽  
Dual Roles ◽  
Self Renewal ◽  
Stem Cell Maintenance ◽  
Drosophila Testis ◽  
Hh Signaling ◽  
Cell Maintenance

Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche

Development ◽  
2012 ◽  
Vol 139 (15) ◽  
pp. 2663-2669 ◽  
Author(s):  
M. Michel ◽  
A. P. Kupinski ◽  
I. Raabe ◽  
C. Bokel
Keyword(s):  
Stem Cell ◽  
Somatic Stem Cell ◽  
Stem Cell Maintenance ◽  
Drosophila Testis ◽  
Cell Maintenance

scholarly journals Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion

2017 ◽  
Vol 216 (5) ◽  
pp. 1439-1453 ◽  
Author(s):  
Chun-Ming Lai ◽  
Kun-Yang Lin ◽  
Shih-Han Kao ◽  
Yi-Ning Chen ◽  
Fu Huang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Adhesion ◽  
Hedgehog Signaling ◽  
Control Cell ◽  
Germline Stem Cell ◽  
Traffic Jam ◽  
Stem Cell Maintenance ◽  
Cell Affinity ◽  
Hh Signaling ◽  
Cell Maintenance

Stem cells require different types of supporting cells, or niches, to control stem cell maintenance and differentiation. However, little is known about how those niches are formed. We report that in the development of the Drosophila melanogaster ovary, the Hedgehog (Hh) gradient sets differential cell affinity for somatic gonadal precursors to specify stromal intermingled cells, which contributes to both germline stem cell maintenance and differentiation niches in the adult. We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammals) is a novel transcriptional target of Hh signaling to control cell–cell adhesion by negative regulation of E-cadherin expression. Our results demonstrate the role of Hh signaling in niche establishment by segregating somatic cell lineages for differentiation.

scholarly journals The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster

2009 ◽  
Vol 185 (4) ◽  
pp. 613-627 ◽  
Author(s):  
Akos Szakmary ◽  
Mary Reedy ◽  
Hongying Qi ◽  
Haifan Lin
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Double Mutant ◽  
Terminal Region ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
Stem Cell Maintenance ◽  
Male Germline ◽  
Cytoplasmic Structures ◽  
Cell Maintenance

Yb regulates the proliferation of both germline and somatic stem cells in the Drosophila melanogaster ovary by activating piwi and hh expression in niche cells. In this study, we show that Yb protein is localized as discrete cytoplasmic spots exclusively in the somatic cells of the ovary and testis. These spots, which are different from all known cytoplasmic structures in D. melanogaster, are evenly electron-dense spheres 1.5 µm in diameter (herein termed the Yb body). The Yb body is frequently associated with mitochondria and a less electron-dense sphere of similar size that appears to be RNA rich. There are one to two Yb bodies/cell, often located close to germline cells. The N-terminal region of Yb is required for hh expression in niche cells, whereas the C-terminal region is required for localization to Yb bodies. The entire Yb protein is necessary for piwi expression in niche cells. A double mutant of Yb and a novel locus show male germline loss, revealing a function for Yb in male germline stem cell maintenance.

scholarly journals Silver nanoparticles disrupt germline stem cell maintenance in the Drosophila testis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Cynthia Ong ◽  
Qian Ying Lee ◽  
Yu Cai ◽  
Xiaoli Liu ◽  
Jun Ding ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Stem Cell ◽  
Germline Stem Cell ◽  
Stem Cell Maintenance ◽  
Drosophila Testis ◽  
Cell Maintenance
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