scholarly journals Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

2011 ◽  
Vol 36 (3) ◽  
pp. 422-430 ◽  
Author(s):  
B Gaborit ◽  
F Kober ◽  
A Jacquier ◽  
P J Moro ◽  
T Cuisset ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Visceral Fat ◽  
Metabolic Profile ◽  
Epicardial Fat ◽  
Severely Obese ◽  
Triglyceride Content ◽  
Epicardial Fat Volume ◽  
Obese Subjects ◽  
Fat Volume ◽  
Myocardial Triglyceride Content

Relation of visceral fat and haemodynamics in adults with Fontan circulation

2020 ◽  
Vol 30 (7) ◽  
pp. 995-1000
Author(s):  
Adam M. Lubert ◽  
Tarek Alsaied ◽  
Andrew T. Trout ◽  
Jonathan R. Dillman ◽  
Bryan H. Goldstein
Keyword(s):  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Epicardial Fat ◽  
Epicardial Fat Volume ◽  
Subcutaneous Fat Thickness ◽  
Fat Thickness ◽  
Abdominal Visceral Fat ◽  
Fat Volume

AbstractBeing overweight is associated with reduced functional capacity in Fontan patients. Increased adiposity leads to accumulation of epicardial and intra-abdominal visceral fat, which produce proinflammatory cytokines and may affect endothelial function. This retrospective study to evaluate the association between visceral fat and Fontan haemodynamics included 23 Fontan patients >18 years old with MRI and catheterization data available. Epicardial fat volume indexed to body surface area was measured by cardiac MRI, and intra-abdominal visceral fat thickness and subcutaneous fat thickness were derived from abdominal MRI. Stepwise regression models were used to determine univariable and multivariable associations between fat measures and haemodynamics. Mean age was 28.2 ± 9.5 years and body mass index was 26 ± 4 kg/m2. Mean central venous pressure was 13 ± 3 mmHg and pulmonary vascular resistance index was 1.23WU·m2 (interquartile range: 0.95–1.56). Epicardial fat volume was associated with age (r2 = 0.37, p = 0.002), weight (r2 = 0.26, p = 0.013), body mass index (r2 = 0.27, p = 0.011), and intra-abdominal visceral fat (r2 = 0.30, p = 0.018). Subcutaneous fat thickness did not relate to these measures. There was modest correlation between epicardial fat volume and pulmonary vascular resistance (r2 = 0.27, p = 0.02) and a trend towards significant correlation between intra-abdominal fat thickness and pulmonary vascular resistance (r2 = 0.21, p = 0.06). Subcutaneous fat thickness was not associated with Fontan haemodynamics. In multivariable analysis, including age and visceral fat measures, epicardial fat was independently correlated with pulmonary vascular resistance (point estimate 0.13 ± 0.05 per 10 ml/m2 increase, p = 0.03). In conclusion, in adults with Fontan circulation, increased visceral fat is associated with higher pulmonary vascular resistance. Excess visceral fat may represent a therapeutic target to improve Fontan haemodynamics.

scholarly journals CMR assessment of epicardial fat volume in human morbid obesity at 3 T: relationship to cardiac function and morphology

2010 ◽  
Vol 12 (S1) ◽  
Author(s):  
Bénédicte Gaborit ◽  
Frank Kober ◽  
Pierre-Julien Moro ◽  
Alexis Jacquier ◽  
Alexandre Vignaud ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Cardiac Function ◽  
Epicardial Fat ◽  
Epicardial Fat Volume ◽  
Fat Volume

scholarly journals Prognostic implications of epicardial fat volume quantification in acute pericarditis

2016 ◽  
Vol 47 (2) ◽  
pp. 129-136 ◽  
Author(s):  
George Lazaros ◽  
Alexios S. Antonopoulos ◽  
Evangelos K. Oikonomou ◽  
Panagiotis Vasileiou ◽  
Evangelos Oikonomou ◽  
...  
Keyword(s):  
Epicardial Fat ◽  
Acute Pericarditis ◽  
Epicardial Fat Volume ◽  
Prognostic Implications ◽  
Fat Volume

Abstract 14819: Excess Epicardial Fat Volume is Associated With Increased Cardiovascular Structural and Functional Abnormalities in Menopausal Women Regardless of Body Weight: The Higher the Epicardial Fat Volume, the Higher the Abnormalities

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Mahfouz EL SHAHAWY ◽  
Susan Tucker ◽  
Lillee Izadi ◽  
Antonella Sabatini
Keyword(s):  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Significant Risk ◽  
Epicardial Fat ◽  
Ct Scanner ◽  
Cvd Risk ◽  
Artery Stiffness ◽  
Epicardial Fat Volume ◽  
Asymptomatic Subjects ◽  
Fat Volume

Background: It has been reported that an increase in epicardial fat volume (EFV) has been associated with an increase in cardiovascular structural and functional abnormalities (CVSFA). Purpose: The purpose of this study is to assess whether a step-wise increase in EFV is associated with a proportional increase in CVSFA. Methods: We screened 2,756 asymptomatic subjects, ages 20-79, for CVD risk using the Early Cardiovascular Disease Risk Scoring System (ECVDRS), which consists of 10 tests; 7 are vascular and 3 are cardiac. The vascular tests are: large (C1) and small (C2) artery stiffness, blood pressure (BP) at rest and post-mild protocol exercise (PME), CIMT, abdominal aorta ultrasound, retinal photography, and microalbuminuria. The 3 cardiac tests are: Pro-BNP, ECG, and LV ultrasound. Additional tests are waist circumference, BMI, fasting blood sugar, lipid profile, and CRP. 596 out of the total subjects were asymptomatic, and out of these 220 (37%) underwent cardiac CT for coronary artery calcium scoring (CACS) and EFV determination using Siemens Somatom Definition Dual source CT scanner 64x2. 107 out of the 220 were females (48%). These females were divided into 5 groups based on their EFV: 24 with < 69cm 3 ; 33 between 70cm 3 and 94cm 3 ; 16 between 95cm 3 and 119cm 3 ; 20 between 120cm 3 and 144cm 3 ; and 14 >145cm 3 . Results: As noted in the table, a step-wise increase in EFV was associated with proportional increases in CVSFA, specifically CACS, resting BP, abnormal rise in BP-PME, CRP, and triglycerides. An increase in EFV was noticeably associated with an increase in resting blood BP by a 10mmHg difference between the group whose EFV < 120cm 3 and those whose EFV is > 120cm 3 . Conclusions: Based on our data, we feel that excess EFV appears to be the villain for most CVSFA. Accordingly, we urge all healthcare professionals that it is time to focus on early and accurate assessment of this significant risk marker, which is the culprit for many CVD risk factors. Early detect to protect.

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