scholarly journals Reversibility of Hemodynamic Hypofrontality in Schizophrenia

1987 ◽  
Vol 7 (1) ◽  
pp. 9-12 ◽  
Author(s):  
G. Geraud ◽  
M. C. Arné-Bès ◽  
A. Güell ◽  
A. Bes
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Frontal Lobes ◽  
Regional Cerebral Blood ◽  
Chronic Patients ◽  
Chronic Form

Regional cerebral blood flow (CBF) was studied in 51 young schizophrenics. A significant decrease of CBF was seen in frontal and prefrontal regions (hypofrontal pattern) in chronic patients whose disease had evolved for more than 2 years and who were in remission. This hypofrontal pattern was reversible, as it disappeared during exacerbation of the disease. In 10 patients who had not been treated with neuroleptics for several weeks, we found a dopaminergic hypersensitivity in the frontal lobes, as a weak dose of piribedil restored near-normal frontality. This may reflect either the role of neuroleptic washout or a primitive dopaminergic depletion, as proposed by some authors in the chronic form of schizophrenia.

scholarly journals Sound Richness of Music Might Be Mediated by Color Perception: A PET Study

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Masayuki Satoh ◽  
Ken Nagata ◽  
Hidekazu Tomimoto
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Multisensory Integration ◽  
Regional Cerebral Blood Flow ◽  
Traditional Music ◽  
Simple Condition ◽  
Regional Cerebral Blood ◽  
Subtraction Technique ◽  
Posterior Portion

Objects. We investigated the role of the fusiform cortex in music processing with the use of PET, focusing on the perception of sound richness.Method. Musically naïve subjects listened to familiar melodies with three kinds of accompaniments: (i) an accompaniment composed of only three basic chords (chord condition), (ii) a simple accompaniment typically used in traditional music text books in elementary school (simple condition), and (iii) an accompaniment with rich and flowery sounds composed by a professional composer (complex condition). Using a PET subtraction technique, we studied changes in regional cerebral blood flow (rCBF) in simple minus chord, complex minus simple, and complex minus chord conditions.Results. The simple minus chord, complex minus simple, and complex minus chord conditions regularly showed increases in rCBF at the posterior portion of the inferior temporal gyrus, including the LOC and fusiform gyrus.Conclusions. We may conclude that certain association cortices such as the LOC and the fusiform cortex may represent centers of multisensory integration, with foreground and background segregation occurring at the LOC level and the recognition of richness and floweriness of stimuli occurring in the fusiform cortex, both in terms of vision and audition.

A-87 Regional Cerebral Blood Flow in Self-Reported Somatic Anxiety

2021 ◽  
Vol 36 (6) ◽  
pp. 1134-1134
Author(s):  
Bailey E McDonald ◽  
Samantha C Spagna ◽  
Brittany D Parker ◽  
Charles Golden ◽  
Kristen Willeumier ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Frontal Lobe ◽  
Regional Cerebral Blood Flow ◽  
Frontal Lobes ◽  
Mediating Effect ◽  
Regional Cerebral Blood ◽  
Anxiety Group ◽  
Somatic Anxiety ◽  
Clinical Measures

Abstract Objective To identify regional cerebral blood flow (rCBF) differences between individuals who self-reported either low or high symptoms of somatic anxiety. Method Individuals who reported low levels of somatic anxiety (0-20th percentile;n = 8962,Mage = 39.2,39.2% female,62.6% Caucasian) and individuals who reported high levels of somatic anxiety (80-100th percentile;n = 6427,Mage = 40.9,39.0% female,69.5% Caucasian) were selected from a deidentified adult clinical outpatient database. Those with comorbid diagnoses were included. Significant differences (alpha = 0.001) were found for age [t(15387) = 6.3], and race [χ2(15) = 119.4] between groups and therefore were controlled. Results Significant rCBF differences were noted bilaterally in the frontal lobe [left: F(1,15,384) = 16.4; right: F(1,15,384) = 13.2] and motor-sensory strip [left: F(1,15,384) = 4.3; right: F(1,15,384) = 5.1]. Group means comparisons indicated higher perfusion in the frontal lobe of the high levels of somatic anxiety group. Lower perfusion was found in the motor sensory strip of the high levels of somatic anxiety group. No significant differences were found bilaterally in the cerebellum, limbic system, basal ganglia, vermis, or occipital, parietal, or temporal lobes. Conclusion Results indicated that individuals who report higher levels of somatic anxiety have higher perfusion in the frontal lobes and lower perfusion motor-sensory strip. Previous literature SPECT studies have found a link between individuals with panic disorder and increased activity in the right medial and superior frontal lobes. No research was found for anxiety in the motor-sensory strip. Limitations included the reliance on self-report measures of anxiety in place of clinical measures and the potential mediating effect of medication on somatic symptoms. Future research should examine perfusion in the motor-sensory strip, use clinical measures of anxiety, and control for mediation use.

scholarly journals The Relationship Between Regional Cerebral Blood Flow Estimates and Alcohol Problems at 5‐Year Follow‐Up: The Role of Level of Response

2019 ◽  
Vol 43 (5) ◽  
pp. 812-821 ◽  
Author(s):  
Kelly E. Courtney ◽  
Maria Alejandra Infante ◽  
Gregory G. Brown ◽  
Susan F. Tapert ◽  
Alan N. Simmons ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Alcohol Problems ◽  
Regional Cerebral Blood ◽  
The Relationship

Acute Effects of Alcohol Administration on Regional Cerebral Blood Flow: The Role of Acetate

1993 ◽  
Vol 17 (6) ◽  
pp. 1119-1123 ◽  
Author(s):  
Joseph A. Schwartz ◽  
Nancy M. Speed ◽  
Milton D. Gross ◽  
Michael R. Lucey ◽  
Andrew M. Bazakis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Acute Effects ◽  
Regional Cerebral Blood ◽  
Alcohol Administration

Regional cerebral blood flow in schizophrenia while performing an attention task

2014 ◽  
Author(s):  
Scott Harcourt ◽  
Daniel G. Amen ◽  
Kristin C. Willeumier ◽  
Charles J. Golden
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Attention Task

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

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