Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

Regional cerebral blood flow in endogenous psychoses, measured by 99mTc HMPAO-SPECT

1990 ◽  
Vol 1 (1) ◽  
pp. 71-73 ◽  
Author(s):  
Heinrich Sauer ◽  
Johannes Schröder ◽  
Henning Henningsen ◽  
Karl-R. Wilhelm ◽  
Peter Georgi
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
99Mtc Hmpao

Regional cerebral blood flow in endogenous psychoses: A Tc-99m HMPAO-SPECT pilot study

1989 ◽  
Vol 29 (3) ◽  
pp. 331-333 ◽  
Author(s):  
J. Schroeder ◽  
H. Sauer ◽  
K.-R. Wilhelm ◽  
T. Niedermeier ◽  
P. Georgi
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses

Functional and Morphological Findings in Early and Advanced Stages of HIV Infection: a Comparison of 99mTc-HMPAO SPECT with CT and MRI Studies

1990 ◽  
Vol 29 (06) ◽  
pp. 252-258 ◽  
Author(s):  
Eva Schielke ◽  
W. M. Bauer ◽  
A. Markl ◽  
K. M. Einhäupl ◽  
C.-M. Kirsch ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Hiv Infection ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Hiv Encephalopathy ◽  
Hmpao Spect ◽  
Advanced Stages ◽  
99Mtc Hmpao ◽  
Ct And Mri

In fourty patients at early and advanced stages of HIV infection (Walter Reed stages I—VI) regional cerebral blood flow was determined by 99mTc-HMPAO SPECT, comparing the results with CT and MRI findings. All patients with HIV encephalopathy (AIDS dementia complex) had pathologic SPECT results (multilocular, patchy uptake defects), but also in earlier and even earliest stages of HIV infection positive SPECT findings were observed. Compared to functional SPECT imaging, morphologically orientated methods (CT, MRI) were insensitive in detecting HIV-induced foci: more than 50% of the patients with pathologic SPECT findings had negative CT or MRI scans. Most patients in advanced Walter Reed stages had neurological abnormalities accompanied by positive SPECT. Subtle alterations of HMPAO uptake were observed even in a few cases of early HIV infection without neurological CNS symptoms. The data presented suggest that HMPAO SPECT is highly sensitive in the detection of altered brain perfusion not only in advanced but also early stages of HIV infection. Changes in regional cerebral blood flow are present before noticeable structural defects may be observed. Thus, it is suggested to use HMPAO SPECT in the evaluation and monitoring of patients with, and particularly at risk for, HIV encephalopathy.

scholarly journals The influence of subanaesthetic ketamine on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0209316
Author(s):  
Lise Vlerick ◽  
Kathelijne Peremans ◽  
Robrecht Dockx ◽  
Kurt Audenaert ◽  
Chris Baeken ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Healthy Dogs ◽  
99Mtc Hmpao
Sign in / Sign up

Export Citation Format

Share Document