scholarly journals Erratum: Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

2011 ◽  
Vol 91 (6) ◽  
pp. 968-968
Author(s):  
Motoko Sasaki ◽  
Masami Miyakoshi ◽  
Yasunori Sato ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Biliary Cirrhosis

Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss

2005 ◽  
Vol 205 (4) ◽  
pp. 451-459 ◽  
Author(s):  
Motoko Sasaki ◽  
Hiroko Ikeda ◽  
Hironori Haga ◽  
Toshiaki Manabe ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Bile Ducts ◽  
Biliary Cirrhosis

scholarly journals Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Bile Ducts ◽  
Causative Factor ◽  
Biliary Cirrhosis ◽  
Novel Approach ◽  
Bile Duct Damage ◽  
Chronic Nonsuppurative Destructive Cholangitis ◽  
Bile Duct Lesions

Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. The autoimmune-mediated pathogenesis of bile duct lesions, including the significance of AMAs, triggers of the autoimmune process, and so on remain unclear. We have reported that cellular senescence in biliary epithelial cells (BECs) may be involved in bile duct lesions and that autophagy may precede the process of biliary epithelial senescence in PBC. Interestingly, BECs in damaged bile ducts show characteristicsof cellular senescence and autophagy in PBC. A suspected causative factor of biliary epithelial senescence is oxidative stress. Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC.

scholarly journals Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

2010 ◽  
Vol 90 (6) ◽  
pp. 835-843 ◽  
Author(s):  
Motoko Sasaki ◽  
Masami Miyakoshi ◽  
Yasunori Sato ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Biliary Cirrhosis

Pathology and Immunopathology of Primary Biliary Cirrhosis With Emphasis On Bile Duct Lesions: Recent Progress

1995 ◽  
Vol 15 (04) ◽  
pp. 313-328 ◽  
Author(s):  
Yasuni Nakanuma ◽  
Koichi Tsuneyama ◽  
M. Gershwin ◽  
Mitsue Yasoshima
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Recent Progress ◽  
Biliary Cirrhosis ◽  
Bile Duct Lesions

Increased cd1d expression on small bile duct epithelium and epithelioid granuloma in livers in primary biliary cirrhosis

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 620-623 ◽  
Author(s):  
Koichi Tsuneyama ◽  
Mitsue Yasoshima ◽  
Kenichi Harada ◽  
Katsushi Hiramatsu ◽  
M. Eric Gershwin ◽  
...  
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Epithelioid Granuloma ◽  
Duct Epithelium ◽  
Small Bile Duct ◽  
Bile Duct Epithelium
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