scholarly journals Erratum: Conserved and host-specific features of influenza virion architecture

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Edward C. Hutchinson ◽  
Philip D. Charles ◽  
Svenja S. Hester ◽  
Benjamin Thomas ◽  
David Trudgian ◽  
...  
Keyword(s):  
Influenza Virion

Influenza virion transcriptase: synthesis in vitro of large, polyadenylic acid-containing complementary RNA.

1977 ◽  
Vol 21 (1) ◽  
pp. 24-34 ◽  
Author(s):  
S J Plotch ◽  
R M Krug
Keyword(s):  
Influenza Virion ◽  
Polyadenylic Acid

Transcription and Replication of Influenza Virion RNA in the Nucleus of Infected Cells

1987 ◽  
Vol 52 (0) ◽  
pp. 353-358 ◽  
Author(s):  
R.M. Krug ◽  
C. St. Angelo ◽  
B. Broni ◽  
G. Shapiro
Keyword(s):  
Influenza Virion ◽  
Infected Cells ◽  
Transcription And Replication

scholarly journals Nothing to Sneeze at: A Full-Scale Computational Model of the Human Influenza Virion

2015 ◽  
Vol 108 (2) ◽  
pp. 31a
Author(s):  
Tyler Reddy ◽  
David Shorthouse ◽  
Daniel Parton ◽  
Elizabeth Jefferys ◽  
Philip W. Fowler ◽  
...  
Keyword(s):  
Computational Model ◽  
Full Scale ◽  
Human Influenza ◽  
Influenza Virion

scholarly journals The role of N-acetylneuraminic (sialic) acid in the pH dependence of influenza virion fusion with planar phospholipid membranes.

1991 ◽  
Vol 97 (6) ◽  
pp. 1121-1140 ◽  
Author(s):  
W D Niles ◽  
F S Cohen
Keyword(s):  
Influenza Virus ◽  
Sialic Acid ◽  
Ph Dependence ◽  
Phospholipid Composition ◽  
Fusion Rate ◽  
Influenza Virion ◽  
Order Of Magnitude ◽  
Ph Dependent ◽  
Planar Membrane ◽  
Planar Membranes

It is known that fusion of influenza virus to host cell membranes is strongly promoted by acidic pH. We have determined conditions required to obtain pH-dependent fusion of influenza virus to planar bilayer membranes. The rate of viral fusion was determined from the flash rate of R18-labeled virions delivered to the surface of the planar membrane by pressure-ejection from a pipette. For a bilayer formed only of phospholipids and cholesterol, the fusion rate was independent of pH and unaffected by the phospholipid composition. When the gangliosides GD1a + GT1b were included in the planar membrane, however, the fusion rate varied steeply with pH. The rate at pH 7.4 in the presence of the gangliosides was about an order of magnitude less than in their absence. At pH less than approximately 5.5, the rate was about an order of magnitude greater in the presence of gangliosides than in their absence. The fusion rate with planar membranes containing globoside, a ceramide-backboned glycolipid, was also independent of pH, indicating that the pH dependence required sialic acid on the carbohydrate moiety of the glycolipid. The gangliosides GM1a and GM3, both of which possess sialic acid, produced the same pH-dependent fusion rate as seen with GD1a + GT1b, indicating that the presence, but not the location, of terminal sialic acids is critical. Incubating virus with soluble sialyllactose blocked fusion to both ganglioside-free and ganglioside-containing planar membranes. These results show that the pH dependence of influenza virion fusion arises from the interaction of the sialic acid receptor with the influenza hemagglutinin. A model for sialic acid-hemagglutinin interactions accounting for pH-dependent fusion is presented.

scholarly journals Conserved and host-specific features of influenza virion architecture

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Edward C. Hutchinson ◽  
Philip D. Charles ◽  
Svenja S. Hester ◽  
Benjamin Thomas ◽  
David Trudgian ◽  
...  
Keyword(s):  
Influenza Virion

scholarly journals Altering the size distribution of influenza virion populations

2019 ◽  
Vol 1 (1A) ◽  
Author(s):  
Amy Burke ◽  
Jack Hirst ◽  
Edward Hutchinson
Keyword(s):  
Size Distribution ◽  
Influenza Virion

scholarly journals Synthesis of the templates for influenza virion RNA replication in vitro.

1984 ◽  
Vol 81 (15) ◽  
pp. 4682-4686 ◽  
Author(s):  
A. R. Beaton ◽  
R. M. Krug
Keyword(s):  
Rna Replication ◽  
Influenza Virion

scholarly journals A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models

2009 ◽  
Vol 3 (3) ◽  
pp. 107-117 ◽  
Author(s):  
Rebecca J. Cox ◽  
Diane Major ◽  
Solveig Hauge ◽  
Abdullah S. Madhun ◽  
Karl A. Brokstad ◽  
...  
Keyword(s):  
Influenza Virion ◽  
A Cell

scholarly journals The Immunogenicity of a Cell-derived H7N1 Split Influenza Virion Vaccine in Mice

2009 ◽  
Vol 69 (6) ◽  
pp. 576-578 ◽  
Author(s):  
S. Hauge ◽  
A. S. Madhun ◽  
D. Major ◽  
K. A. Brokstad ◽  
F. R. Vogel ◽  
...  
Keyword(s):  
Influenza Virion ◽  
A Cell
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