scholarly journals Erratum: Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Rubing Zhao-Shea ◽  
Steven R. DeGroot ◽  
Liwang Liu ◽  
Markus Vallaster ◽  
Xueyan Pang ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Nicotine Withdrawal ◽  
Interpeduncular Nucleus ◽  
Medial Habenula ◽  
Ventral Tegmental

scholarly journals Distinct neuronal subtypes of the lateral habenula differentially target ventral tegmental area dopamine neurons

2019 ◽  
Author(s):  
Michael L. Wallace ◽  
Kee Wui Huang ◽  
Daniel Hochbaum ◽  
Minsuk Hyun ◽  
Gianna Radeljic ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Molecular Diversity ◽  
Transcriptional Profiling ◽  
Retrograde Tracing ◽  
Dopamine Neurons ◽  
Lateral Habenula ◽  
Subtype Specificity ◽  
Medial Habenula ◽  
Neuronal Subtype ◽  
Ventral Tegmental

ABSTRACTThe lateral habenula (LHb) is an epithalamic brain structure critical for processing and adapting to negative action outcomes. However, despite the importance of LHb to behavior and the clear anatomical and molecular diversity of LHb neurons, the neuron types of the habenula remain unknown. Here we use high-throughput single-cell transcriptional profiling, monosynaptic retrograde tracing, and multiplexed FISH to characterize the cells of the mouse habenula. We find 5 subtypes of neurons in the medial habenula (MHb) that are organized into anatomical subregions. In the LHb we describe 4 neuronal subtypes and show that they differentially target dopaminergic and GABAergic cells in the ventral tegmental area (VTA). These data provide a valuable resource for future study of habenular function and dysfunction and demonstrate neuronal subtype specificity in the LHb-VTA circuit.

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