scholarly journals Genome-wide association study identifies five new breast cancer susceptibility loci

2010 ◽  
Vol 42 (6) ◽  
pp. 504-507 ◽  
Author(s):  
Clare Turnbull ◽  
◽  
Shahana Ahmed ◽  
Jonathan Morrison ◽  
David Pernet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

scholarly journals A Pilot Genome-wide Association Study of Breast Cancer Susceptibility Loci in Indonesia

2015 ◽  
Vol 16 (6) ◽  
pp. 2231-2235 ◽  
Author(s):  
Samuel J Haryono ◽  
I Gusti Bagus Datasena ◽  
Wahyu Budi Santosa ◽  
Raymond Mulyarahardja ◽  
Kartika Sari
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

scholarly journals Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci

2016 ◽  
Vol 25 (15) ◽  
pp. 3361-3371 ◽  
Author(s):  
Mi-Ryung Han ◽  
Jirong Long ◽  
Ji-Yeob Choi ◽  
Siew-Kee Low ◽  
Sun-Seog Kweon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
East Asians ◽  
Genome Wide

scholarly journals Genome-wide association study identifies novel breast cancer susceptibility loci

Nature ◽  
2007 ◽  
Vol 447 (7148) ◽  
pp. 1087-1093 ◽  
Author(s):  
Douglas F. Easton ◽  
◽  
Karen A. Pooley ◽  
Alison M. Dunning ◽  
Paul D. P. Pharoah ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

scholarly journals Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

2019 ◽  
Author(s):  
Haoyu Zhang ◽  
Thomas U. Ahearn ◽  
Julie Lecarpentier ◽  
Daniel Barnes ◽  
Jonathan Beesley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
European Ancestry ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

AbstractBreast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status and tumor grade. We identified 32 novel susceptibility loci (P<5.0×10-8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate <0.05). Five loci showed associations (P<0.05) in opposite directions between luminal- and non-luminal subtypes. In-silico analyses showed these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 37.6% for triple-negative and 54.2% for luminal A-like disease. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.

scholarly journals Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer

2013 ◽  
Vol 35 (5) ◽  
pp. 1012-1019 ◽  
Author(s):  
Kristen S. Purrington ◽  
Susan Slager ◽  
Diana Eccles ◽  
Drakoulis Yannoukakos ◽  
Peter A. Fasching ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

scholarly journals Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62550 ◽  
Author(s):  
Yadav Sapkota ◽  
Yutaka Yasui ◽  
Raymond Lai ◽  
Malinee Sridharan ◽  
Paula J. Robson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide ◽  
A Genome

scholarly journals Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility

2011 ◽  
Vol 130 (4) ◽  
pp. 529-537 ◽  
Author(s):  
Badan Sehrawat ◽  
Malinee Sridharan ◽  
Sunita Ghosh ◽  
Paula Robson ◽  
Carol E. Cass ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

2009 ◽  
Vol 41 (3) ◽  
pp. 324-328 ◽  
Author(s):  
Wei Zheng ◽  
Jirong Long ◽  
Yu-Tang Gao ◽  
Chun Li ◽  
Ying Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide
Sign in / Sign up

Export Citation Format

Share Document