scholarly journals Neurotoxic esterase: not so toxic?

2003 ◽  
Vol 33 (4) ◽  
pp. 437-438 ◽  
Author(s):  
James P. O'Callaghan
Keyword(s):  
Neurotoxic Esterase

SUBCELLULAR DISTRIBUTION OF MARKER ENZYMES AND OF NEUROTOXIC ESTERASE IN ADULT HEN BRAIN

1979 ◽  
Vol 32 (2) ◽  
pp. 607-615 ◽  
Author(s):  
R. J. Richardson ◽  
C. S. Davis ◽  
M. K. Johnson
Keyword(s):  
Subcellular Distribution ◽  
Marker Enzymes ◽  
Neurotoxic Esterase

scholarly journals Solubilization of hen brain neurotoxic esterase in dimethylsulfoxide

1985 ◽  
Vol 132 (1) ◽  
pp. 81-87 ◽  
Author(s):  
B.W. Schwab ◽  
C-S.G. Davis ◽  
P.H. Miller ◽  
R.J. Richardson
Keyword(s):  
Neurotoxic Esterase

In vitro and in vivo inhibition of chicken brain neurotoxic esterase by leptophos analogs

1983 ◽  
Vol 20 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Jan Hendrik Reinders ◽  
Larry G. Hansen ◽  
Robert L. Metcalf ◽  
Robert A. Metcalf
Keyword(s):  
Chicken Brain ◽  
Neurotoxic Esterase

Neurotoxic esterase in the land snails: In vitro comparative and kinetic studies

1993 ◽  
Vol 28 (3) ◽  
pp. 325-334
Author(s):  
K. A. Osraan ◽  
A. K. Salama ◽  
M. A. Radwan
Keyword(s):  
Kinetic Studies ◽  
Land Snails ◽  
Neurotoxic Esterase

scholarly journals Characterization of [3H]di-isopropyl phosphorofluoridate-binding proteins in hen brain. Rates of phosphorylation and sensitivity to neurotoxic and non-neurotoxic organophosphorus compounds

1985 ◽  
Vol 228 (3) ◽  
pp. 537-544 ◽  
Author(s):  
C D Carrington ◽  
M B Abou-Donia
Keyword(s):  
Organophosphorus Compound ◽  
Binding Proteins ◽  
Organophosphorus Compounds ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Reaction Rates ◽  
Binding Activity ◽  
Binding Characteristics ◽  
Delayed Neurotoxicity ◽  
Neurotoxic Esterase

The experiments described in this paper were designed to isolate [3H]di-isopropyl phosphorofluoridate-binding proteins by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis for the purpose of characterizing and identifying potential initiation sites for organophosphorus-compound-induced delayed neurotoxicity. The major Paraoxon-insensitive Mipafox-sensitive binding protein (Mr 160 000) was found to be identical with one previously identified as neurotoxic esterase, an enzyme that has been proposed to be the target site for organophosphorus-compound-induced delayed neurotoxicity. However, two other binding proteins with suitable binding characteristics were also found in smaller amounts, one of which has not been detected previously. Di-isopropyl phosphorofluoridate was found to phosphorylate all three of these proteins at rates similar to the rate at which neurotoxic esterase is inhibited by di-isopropyl phosphorofluoridate. Varying the concentration of di-isopropyl phosphorofluoridate or the time of incubation produced similar increases in binding to each of the labelled proteins. This suggests that the reaction rates of di-isopropyl phosphorofluoridate with proteins may be described by first-order kinetics, and the concentration of the Michael is complex formed during binding is minimal for all the phosphorylated proteins. The recovery of the binding activity in the 160 000-Mr band was found to be similar to the recovery of neurotoxic esterase activity, lending further support to the contention that this band is identical with neurotoxic esterase.

Neurotoxic esterase activity in human platelets, lymphocytes and monocytes

1983 ◽  
Vol 18 ◽  
pp. 23 ◽  
Author(s):  
M.L. Bleecker ◽  
M. Maroni
Keyword(s):  
Esterase Activity ◽  
Human Platelets ◽  
Neurotoxic Esterase
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