reaction rates
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2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Abhijeet Singh ◽  
Pargat Singh ◽  
Mahendra Nath

Abstract Organic transformations using efficient, atom-economical, cost-effective and environmentally benign strategies for the construction of diversified molecules have attracted synthetic chemists worldwide in recent years. These processes often minimize the waste production and avoid the use of hazardous flammable organic solvents. Among various green protocols, the procedures using surfactant-based catalytic systems have received a considerable attention in organic synthesis. In this context, Bronsted acidic surfactants have emerged as efficient catalysts for various C–C, C–O, C–N and C–S bond forming reactions. Many of these reactions occur in water, as Bronsted acidic surfactants have a unique ability of creating hydrophobic pocket through micelle formation in aqueous medium and the substrate molecules react efficiently to afford the targeted products in good yields. In the past, Bronsted acidic surfactant combined catalysts successfully displayed their potential to accelerate the reaction rates of diverse organic transformations. This chapter presents a complete overview on Bronsted acidic surfactants catalyzed organic reactions to construct a variety of aromatic and heteroaromatic molecular frameworks.


2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Hongxia Hao ◽  
Itai Leven ◽  
Teresa Head-Gordon

AbstractReaction rates of common organic reactions have been reported to increase by one to six orders of magnitude in aqueous microdroplets compared to bulk solution, but the reasons for the rate acceleration are poorly understood. Using a coarse-grained electron model that describes structural organization and electron densities for water droplets without the expense of ab initio methods, we investigate the electric field distributions at the air-water interface to understand the origin of surface reactivity. We find that electric field alignments along free O–H bonds at the surface are ~16 MV/cm larger on average than that found for O–H bonds in the interior of the water droplet. Furthermore, electric field distributions can be an order of magnitude larger than the average due to non-linear coupling of intramolecular solvent polarization with intermolecular solvent modes which may contribute to even greater surface reactivity for weakening or breaking chemical bonds at the droplet surface.


2022 ◽  
pp. 107815522110728
Author(s):  
Kelsey Coffman ◽  
Coby Carstens ◽  
Susan Fajardo

Daratumumab, a CD38-directed monoclonal antibody indicated for multiple myeloma treatment in adult patients, is associated with a high incidence of infusion-related reactions (IRRs). Due to CD38 receptor presence in the lungs, many reactions present similarly to asthma or allergic rhinitis. Montelukast, a leukotriene receptor antagonist, has been hypothesized to reduce daratumumab IRRs due to its efficacy in treating allergic rhinitis and asthma and the presence of leukotriene receptors in the lungs. Recently published data reported daratumumab can be safely administered via rapid rate protocol that reduces infusion time from 195 min to 90 min after completion of two doses. This retrospective, observational cohort study examined 73 patients who received daratumumab in the outpatient setting between December 2015 and April 2020. Patients were included if they were 18 years or older, had an International Classification of Disease (ICD)-10 diagnosis code for multiple myeloma, and received daratumumab intravenously. The primary outcome was a comparison of IRRs between those who did and did not receive montelukast. Secondary outcomes included IRR symptoms, rescue medications utilized for IRRs, and rapid rate administration outcomes. Montelukast use was associated with a lower rate of IRRs (44.4% vs. 65.2%, p = 0.044). Pulmonary IRR symptoms were more common in those who did not receive montelukast. Rapid rate administration of daratumumab did not lead to any IRRs. Adding montelukast as a pre-medication for daratumumab infusions led to a reduction in IRRs, and rapid rate administration was found to be safe after completion of two full doses of daratumumab.


2022 ◽  
Vol 12 (2) ◽  
pp. 664
Author(s):  
Michael Auer ◽  
Christoph Wölfler ◽  
Jürgen Antrekowitsch

Electric arc furnace dust (EAFD) is an important secondary resource for the zinc industry. The most common process for its recycling is the pyro-metallurgical treatment in the Waelz process. However, this process focuses on the recycling of the zinc, whereas the recovery of other metals from the EAFD—such as iron and other alloying elements—is neglected. An up-to-date version of reprocessing can involve multi-metal recycling by means of a metal bath containing carbon. The use of a liquid iron alloy requires a higher processing temperature, which enables the reduction and melting of iron oxides as well as other compounds occurring in the dust. Furthermore, the Zn yield is higher and the reduction kinetics are faster than in the Waelz process. This paper is only focused on the zinc reduction in such a metal bath. In order to determine the influence of the carbon content in the molten metal on the reduction rate, experiments were carried out on the reduction behavior of zinc oxide using a synthetic slag. This slag, with a basicity B2 = 1, was applied to an iron bath with varying carbon contents. (0.85%, 2.16%, 2.89%, and 4.15%) The decrease in the zinc oxide concentration was monitored, along with the reaction rates calculated from these data. It was found that the reaction rate increases with rising carbon content in the melt.


2022 ◽  
Vol 11 (2) ◽  
pp. 350
Author(s):  
Sang-Ho Jo ◽  
Seok Min Kang ◽  
Byung Su Yoo ◽  
Young Soo Lee ◽  
Ho Joong Youn ◽  
...  

Background: This study was a multicenter, randomized, double-blinded, placebo-controlled phase III clinical trial to investigate the efficacy and safety of an olmesartan/amlodipine single pill plus rosuvastatin combination treatment for patients with concomitant hypertension and dyslipidemia. Methods: Patients with both hypertension and dyslipidemia aged 20–80 were enrolled from 36 tertiary hospitals in Korea from January 2017 to April 2018. Patients were randomized to three groups in a 1:1:0.5 ratio, olmesartan/amlodipine single pill plus rosuvastatin (olme/amlo/rosu) or olmesartan plus rosuvastatin (olme/rosu) or olmesartan/amlodipine single pill (olme/amlo) combination. The primary endpoints were change of sitting systolic blood pressure (sitSBP) from baseline in the olme/amlo/rosu vs. olme/rosu groups and the percentage change of low-density lipoprotein cholesterol (LDL-C) from baseline in the olme/amlo/rosu vs. olme/amlo groups after 8 weeks of treatment. Results: A total of 265 patients were randomized, 106 to olme/amlo/rosu, 106 to olme/rosu and 53 to olme/amlo groups. Baseline characteristics among the three groups did not differ. The mean sitSBP change was significantly larger in the olme/amlo/rosu group with −24.30 ± 12.62 mmHg (from 153.58 ± 10.90 to 129.28 ± 13.58) as compared to the olme/rosu group, −9.72 ± 16.27 mmHg (from 153.71 ± 11.10 to 144.00 ± 18.44 mmHg). The difference in change of sitSBP between the two groups was −14.62± 1.98 mmHg with significance (95% CI −18.51 to −10.73, p < 0.0001). The mean LDL-C reduced significantly in the olme/amlo/rosu group, −52.31 ± 16.63% (from 154.52 ± 30.84 to 72.72 ± 26.08 mg/dL) as compared to the olme/amlo group with no change, −2.98 ± 16.16% (from 160.42 ± 32.05 to 153.81 ± 31.57 mg/dL). Significant difference in change was found in LDL-C between the two groups with −50.10 ± 2.73% (95% CI −55.49 to −44.71, p < 0.0001). Total adverse drug reaction rates were 10.48%, 5.66% and 3.7% in the olme/amlo/rosu, olme/rosu and olme/amlo groups, respectively with no statistical significance among the three groups. Serious adverse drug reactions did not occur. Conclusions: Olmesartan/amlodipine single pill plus rosuvastatin combination treatment for patients with both hypertension and dyslipidemia is effective and safe as compared to either olmesartan plus rosuvastatin or olmesartan plus amlodipine treatment.


Electronics ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 216
Author(s):  
Fei Tan ◽  
Jin Xu

The measurement of thermodynamic properties of chemical or biological reactions were often confined to experimental means, which produced overall measurements of properties being investigated, but were usually susceptible to pitfalls of being too general. Among the thermodynamic properties that are of interest, reaction rates hold the greatest significance, as they play a critical role in reaction processes where speed is of essence, especially when fast association may enhance binding affinity of reaction molecules. Association reactions with high affinities often involve the formation of a intermediate state, which can be demonstrated by a hyperbolic reaction curve, but whose low abundance in reaction mixture often preclude the possibility of experimental measurement. Therefore, we resorted to computational methods using predefined reaction models that model the intermediate state as the reaction progresses. Here, we present a novel method called AKPE (ANN-Dependent Kinetic Parameter Extraction), our goal is to investigate the association/dissociation rate constants and the concentration dynamics of lowly-populated states (intermediate states) in the reaction landscape. To reach our goal, we simulated the chemical or biological reactions as system of differential equations, employed artificial neural networks (ANN) to model experimentally measured data, and utilized Particle Swarm Optimization (PSO) algorithm to obtain the globally optimum parameters in both the simulation and data fitting. In the Results section, we have successfully modeled a protein association reaction using AKPE, obtained the kinetic rate constants of the reaction, and constructed a full concentration versus reaction time curve of the intermediate state during the reaction. Furthermore, judging from the various validation methods that the method proposed in this paper has strong robustness and accuracy.


2022 ◽  
Author(s):  
Khalid Fahad Almulhem ◽  
Ataur Malik ◽  
Mustafa Ghazwi

Abstract Acid Fracturing has been one of the most effective stimulation technique applied in the carbonate formations to enhance oil and gas production. The traditional approach to stimulate the carbonate reservoir has been to pump crosslinked gel and acid blends such as plain 28% HCL, emulsified acid (EA) and in-situ gelled acid at fracture rates in order to maximize stimulated reservoir volume with desired conductivity. With the common challenges encountered in fracturing carbonate formations, including high leak-off and fast acid reaction rates, the conventional practice of acid fracturing involves complex pumping schemes of pad, acid and viscous diverter fluid cycles to achieve fracture length and conductivity targets. A new generation of Acid-Based Crosslinked (ABC) fluid system has been deployed to stimulate high temperature carbonate formations in three separate field trials aiming to provide rock-breaking viscosity, acid retardation and effective leak-off control. The ABC fluid system has been progressively introduced, initially starting as diverter / leak off control cycles of pad and acid stages. Later it was used as main acid-based fluid system for enhancing live acid penetration, diverting and reducing leakoff as well as keeping the rock open during hydraulic fracturing operation. Unlike in-situ crosslinked acid based system that uses acid reaction by products to start crosslinking process, the ABC fluid system uses a unique crosslinker/breaker combination independent of acid reaction. The system is prepared with 20% hydrochloric acid and an acrylamide polymer along with zirconium metal for delayed crosslinking in unspent acid. The ABC fluid system is aimed to reduced three fluid requirements to one by eliminating the need for an intricate pumping schedule that otherwise would include: a non-acid fracturing pad stage to breakdown the formation and generate the targeted fracture geometry; a retarded emulsified acid system to achieve deep penetrating, differently etched fractures, and a self-diverting agent to minimize fluid leak-off. This paper describes all efforts behind the introduction of this novel Acid-Based Crossliked fluid system in different field trials. Details of the fluid design optimization are included to illustrate how a single system can replace the need for multiple fluids. The ABC fluid was formulated to meet challenging bottom-hole formation conditions that resulted in encouraging post treatment well performance.


Catalysts ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 78
Author(s):  
Shital B. Potdar ◽  
Chao-Ming Huang ◽  
BVS Praveen ◽  
Sivakumar Manickam ◽  
Shirish H. Sonawane

Catalysts increase reaction rates; however, the surface area to volume ratio of catalysts has a vital role in catalytic activity. The noble metals such as platinum (Pt) and gold (Au) are expensive; despite this, they have proven their existence in catalysis, motivating the synthesis of supported metal catalysts. Metal catalysts need to be highly dispersed onto the support. In this investigation, an ultrasound approach has been attempted to synthesise highly photoactive titanium dioxide (TiO2) nanoparticles by the hydrolysis of titanium tetraisopropoxide in an acetone/methanol mixture. To enhance its photocatalytic activity, TiO2 was doped with Pt. The synthesised photocatalyst was characterised by techniques such as particle size analysis (PSA), XRD, FE-SEM, TEM, and EDX. The enhancement in the surface characteristics of Pt-doped TiO2 compared with bare TiO2 support was confirmed with Brunauer–Emmett–Teller (BET) analysis. The enhanced surface area and uniformity in particle size distribution at the nanoscale level were due to the effects of ultrasonic irradiation. The obtained results corroborated the size and composition of the synthesised catalysts. The size of the catalysts is in the nanometre range, and good dispersion of Pt catalysts over the TiO2 support was observed. The UV-Visible spectroscopy analysis was performed to study the optical properties of the synthesised TiO2 and Pt/TiO2 photocatalysts. An increase in the absorbance was noted when Pt was added to TiO2, which is due to the decrease in the band gap energy.


2022 ◽  
Vol 8 (1) ◽  
pp. 156-162
Author(s):  
Salsabila Syifaunnida ◽  
Agus Kamaludin

The chemistry practicum activity in school is impossible due to the COVID-19 pandemic, whereas practicum is very important to train soft skills and understanding of chemistry materials. This research aimed to develop 5-e learning cycle-based simple chemistry practicum guideline module for students of class XI. The development model used was a 4-D development model. The quality of the product was assessed by one material expert, one media expert, five reviewers (chemistry teachers of high school), and responded by ten students of high school. The instruments used in the research were product quality assessment sheets using a Likert scale and student response sheets, in the form of a questionnaire, using the Guttman scale. The characteristics of the developed practicum module were in the form of a practicum module for hydrocarbons, thermochemistry, reaction rates, and chemical equilibrium, using simple tools and chemicals; being combined with the 5-e learning cycle model. The quality assessment on the practicum module, which was carried out by one material expert, media experts, and reviewers, gained 88.89. 95.83. and 94.00%. All assessments got a score with Very Good score. From these results, it can be concluded that the developed product is feasible to be used as a practicum guideline.


2022 ◽  
Author(s):  
Charles Creissen ◽  
José Guillermo Rivera de la Cruz ◽  
Dilan Karapinar ◽  
Dario Taverna ◽  
Moritz Schreiber ◽  
...  

Electrochemical CO2 reduction presents a sustainable route to the production of chemicals and fuels. Achieving a narrow product distribution with copper catalysts is challenging and conventional material modifications offer limited control over selectivity. Here, we show that the mild cathodic potentials required to reach high currents in an alkaline gas-fed flow cell permits retention of a surface-bound thiol (4-mercaptopyridine), enabling molecule-directed selective formate generation at high reaction rates. Combined experimental and computational results showed that formate production is favoured due to the inhibition of a CO producing pathway caused by destabilising interactions with the anchored molecule. The immobilisation of molecules to inhibit specific carbon-based products therefore offers a novel approach to rationally tune the selectivity of heterogeneous catalysts.


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