scholarly journals Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I

2008 ◽  
Vol 9 (5) ◽  
pp. 551-557 ◽  
Author(s):  
Tiziana Di Pucchio ◽  
Bithi Chatterjee ◽  
Anna Smed-Sörensen ◽  
Sandra Clayton ◽  
Adam Palazzo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Viral Antigen ◽  
Plasmacytoid Dendritic Cells ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Cross Presentation ◽  
Histocompatibility Complex

Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain

10.1038/ni989 ◽  
2003 ◽  
Vol 4 (11) ◽  
pp. 1065-1073 ◽  
Author(s):  
Gregory Lizée ◽  
Genc Basha ◽  
Jacqueline Tiong ◽  
Jean-Pierre Julien ◽  
Meimei Tian ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Dendritic Cell ◽  
Major Histocompatibility Complex Class ◽  
Cytoplasmic Domain ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Cross Presentation ◽  
Histocompatibility Complex

scholarly journals Need for Tripeptidyl-peptidase II in Major Histocompatibility Complex Class I Viral Antigen Processing when Proteasomes are Detrimental

2006 ◽  
Vol 281 (52) ◽  
pp. 39925-39934 ◽  
Author(s):  
Sara Guil ◽  
Marta Rodríguez-Castro ◽  
Francisco Aguilar ◽  
Eugenia M. Villasevil ◽  
Luis C. Antón ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Antigen Processing ◽  
Viral Antigen ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Tripeptidyl Peptidase ◽  
Tripeptidyl Peptidase Ii

scholarly journals Treatment of a glioblastoma patient by vaccination with autologous dendritic cells pulsed with allogeneic major histocompatibility complex class I–matched tumor peptides

2000 ◽  
Vol 9 (6) ◽  
pp. 1-5 ◽  
Author(s):  
Linda M. Liau ◽  
Keith L. Black ◽  
Neil A. Martin ◽  
Steven N. Sykes ◽  
Jeff M. Bronstein ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Major Histocompatibility Complex ◽  
T Cell ◽  
Immune Responses ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Outpatient Basis ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Dendritic cells (DCs) are antigen-presenting cells that play a central role in the initiation and modulation of antitumor immune responses. In this pilot study, we investigated the ability of autologous DCs pulsed ex vivo with allogeneic major histocompatibility complex class I–matched glioblastoma peptides to stimulate host antitumor immune responses when injected as a vaccine. A patient with recurrent brainstem glioblastoma multiforme (GBM) received a series of three intradermal immunizations of antigen-pulsed DCs on an outpatient basis following surgical debulking of her posterior fossa tumor. Dendritic cell vaccination was well tolerated, and no clinical signs of autoimmunity or experimental allergic en-cephalomyelitis were detected. She developed a measurable cellular immune response against the allogeneic glioblastoma peptides used in her vaccine preparation, as demonstrated by in vitro T-cell proliferation assays. In addition, increased T-cell infiltration was noted within the intracranial tumor site in the biopsy sample obtained following DC vaccination. An objective clinical response, however, was not evident, and this patient eventually died 21 months after her disease was diagnosed. To our knowledge, this is the first patient with brain cancer ever to be treated with DC-based immunotherapy. This case illustrates that vaccination with DCs pulsed with acid-eluted glioblastoma peptides is feasible and can induce systemic antigen-specific immunity in a patient with recurrent GBM. Additional studies are necessary to determine the optimum DC doses and antigen loading conditions that may translate into clinical effectiveness and survival benefit for patients with brain tumors. Phase I trials for malignant glioma are currently underway.

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