Genetic diversity of malaria vector

Nature India ◽  
2007 ◽  
Author(s):  
Subhra Priyadarshini
Keyword(s):  
Genetic Diversity ◽  
Malaria Vector

scholarly journals Population genomics reveal distinct and diverging populations of An. minimus in Cambodia - a widespread malaria vector in Southeast Asia

2021 ◽  
Author(s):  
Brandyce St. Laurent ◽  
Nick Harding ◽  
Nick Deason ◽  
Kolthida Oy ◽  
Chea Sok Loeun ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Southeast Asia ◽  
Genome Sequencing ◽  
Malaria Vector ◽  
Population Genomics ◽  
Sequence Data ◽  
Malaria Vectors ◽  
Open Access Resource ◽  
Two Populations ◽  
Access Resource

Anopheles minimus is an important malaria vector throughout its wide geographic range across Southeast Asia. Genome sequencing could provide important insights into the unique malaria transmission dynamics in this region, where many vector species feed and rest outdoors. We describe results from a study using Illumina deep whole-genome sequencing of 302 wild-caught An. minimus collected from three Cambodian provinces over several years (2010, 2014-2016) and seasons to examine the level of population structure and genetic diversity within this species. These specimens cluster into four distinct populations of An. minimus s.s., with two populations overlapping geographically. We describe the underlying genetic diversity and divergence of these populations and investigated the genetic variation in genes known to be involved in insecticide resistance. We found strong signals of selection within these An. minimus populations, most of which were present in the two Northeastern Cambodian populations and differ from those previously described in African malaria vectors. Cambodia is the focus of the emergence and spread of drug-resistant malaria parasites, so understanding the underlying genetic diversity and resilience of the vectors of these parasites is key to implementing effective malaria control and elimination strategies. These data are publicly available as part of the MalariaGEN Vector Observatory, an open access resource of genome sequence data.

scholarly journals Genetic heterogeneity in Anopheles darlingi related to biting behavior in western Amazon

2018 ◽  
Author(s):  
Melina Campos ◽  
Diego Peres Alonso ◽  
Jan E. Conn ◽  
Joseph M. Vinetz ◽  
Kevin J. Emerson ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Malaria Vector ◽  
Amazon Basin ◽  
Genetic Basis ◽  
Control Strategies ◽  
Blood Feeding ◽  
Genetic Component ◽  
Anopheles Darlingi ◽  
Genetic Diversity And Structure ◽  
Biting Behavior

ABSTRACTIn the Amazon Basin, Anopheles (Nyssorhynchus) darlingi is the most aggressive and effective malaria vector. In endemic areas, behavioral aspects of anopheline species such as host preference, biting time and resting location after a blood meal have a key impact on malaria transmission dynamics and transmission control strategies. An. darlingi present a variety in behavior throughout its broad distribution including blood feeding related. To investigate the genetic basis of its biting behaviors, host-seeking An. darlingi were collected in two settlements (Granada and Remansinho) in Acre, Brazil. Mosquitoes were classified by captured location (indoors or outdoors) and time (dusk or dawn). Genome-wide SNPs were used to assess the degree of genetic diversity and structure in these groups. There was evidence of genetic component of biting behavior regarding both location and time in this species. This study supports that An. darlingi blood-feeding behavior has a genetic component. Additional ecological and genomic studies may help to understand the genetic basis of mosquito behavior and address appropriate surveillance and vector control.Author SummaryMalaria is a disease caused by parasite of the genus Plasmodium and is transmitted by mosquitoes of the genus Anopheles. In the Amazon Basin, the main malaria vector is Anopheles darlingi, which is present in high densities in this region. Egg development requires that females of this mosquito seek hosts for blood meals. Anopheles females blood feeding may occur indoor or outdoor the houses and typically from the sunset to dawn. Anopheles darlingi in particular present great variability regarding its behaviour, presenting variety of peak biting times and patterns. This work shows that there is a genetic component that partially explains these two behaviors: location of the blood meal (inside or outside the houses) and time of feeding. Single nucleotide polymorphisms (SNPs) scattered throughout the genome of Anopheles darlingi showed genetic diversity and structure in these groups. A comprehensive understanding of the genetic basis for mosquito behaviour may support innovative vector surveillance and control strategies.

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