Stem cells for Parkinson disease and ALS: replacement or protection?

2004 ◽  
Vol 10 (3) ◽  
pp. 224-225 ◽  
Author(s):  
Clive N Svendsen ◽  
J William Langston
Keyword(s):  
Stem Cells ◽  
Parkinson Disease

Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease

2021 ◽  
Author(s):  
Sara Simorgh ◽  
Rafieh Alizadeh ◽  
Ronk Shabani ◽  
Fariba Karimzadeh ◽  
Elham Seidkhani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Parkinson Disease ◽  
Olfactory Mucosa ◽  
Nasal Route

Resolving Ethical Issues in Stem Cell Clinical Trials: The Example of Parkinson Disease

2010 ◽  
Vol 38 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Bernard Lo ◽  
Lindsay Parham
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Parkinson Disease ◽  
Cell Transplantation ◽  
Ethical Issues ◽  
Current Therapy ◽  
Pluripotent Cells ◽  
Cord Injury

Stem cells derived from pluripotent cells offer the hope of new treatments for diseases for which current therapy is inadequate. Clinical trials are essential in developing effective and safe stem cell therapies and fulfilling this promise. However, such clinical trials raise ethical issues that are more complex than those raised in clinical trials using drugs, cord blood stem cells, or adult stem cells. Several clinical trials are now being carried out with stem cells derived from pluripotent cells, and many more can be expected in light of the rapid scientific progress in the field.Degenerative neurological diseases are desirable targets for stem cell clinical trials. The FDA has approved Phase 1 clinical trials of neural stem cell transplantation for Batten Disease, Pelizaeus-Merzbacher Disease, and spinal cord injury. In Parkinson Disease (PD), stem cell transplantation could correct the primary pathophysiological defect — inadequate levels of the neurotransmitter dopamine. Current treatment is unsatisfactory in late-stage PD.

Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene

Synapse ◽  
2007 ◽  
Vol 61 (12) ◽  
pp. 971-977 ◽  
Author(s):  
Qing-Jun Li ◽  
Ya-Mei Tang ◽  
Jun Liu ◽  
Dao-You Zhou ◽  
Xiang-Pen Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Parkinson Disease

scholarly journals The promise of stem cells in Parkinson disease

2005 ◽  
Vol 115 (1) ◽  
pp. 23-25 ◽  
Author(s):  
J. William Langston
Keyword(s):  
Stem Cells ◽  
Parkinson Disease

scholarly journals The promise of stem cells in Parkinson disease

2005 ◽  
Vol 115 (1) ◽  
pp. 23-25 ◽  
Author(s):  
J. W. Langston
Keyword(s):  
Stem Cells ◽  
Parkinson Disease
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