scholarly journals Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons

2016 ◽  
Vol 41 (8) ◽  
pp. 2178-2187 ◽  
Author(s):  
Bryan F Singer ◽  
Nancy Bubula ◽  
Dongdong Li ◽  
Magdalena M Przybycien-Szymanska ◽  
Vytautas P Bindokas ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dendritic Spine ◽  
Contextual Stimuli ◽  
Spine Dynamics

The effect of kainic acid on hippocampal dendritic spine dynamics

2016 ◽  
Vol 26 ◽  
pp. S302
Author(s):  
T. Lortkipanidze ◽  
T. Bikashvili ◽  
M. Kiladze
Keyword(s):  
Kainic Acid ◽  
Dendritic Spine ◽  
Spine Dynamics

scholarly journals An in vitro reproduction of stress-induced memory defects: Effects of corticoids on dendritic spine dynamics

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shinichi Saito ◽  
Satoshi Kimura ◽  
Naoki Adachi ◽  
Tadahiro Numakawa ◽  
Akihiko Ogura ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Spine Dynamics

scholarly journals BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors

2017 ◽  
Vol 114 (35) ◽  
pp. 9469-9474 ◽  
Author(s):  
Ethan M. Anderson ◽  
Anne Marie Wissman ◽  
Joyce Chemplanikal ◽  
Nicole Buzin ◽  
Daniel Guzman ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dendritic Spine ◽  
Morphological Changes ◽  
Dominant Negative ◽  
Addictive Behaviors ◽  
Spine Density ◽  
Nucleus Accumbens Shell ◽  
Self Administration ◽  
Dendritic Spine Density ◽  
Chronic Cocaine

Chronic cocaine use is associated with prominent morphological changes in nucleus accumbens shell (NACsh) neurons, including increases in dendritic spine density along with enhanced motivation for cocaine, but a functional relationship between these morphological and behavioral phenomena has not been shown. Here we show that brain-derived neurotrophic factor (BDNF) signaling through tyrosine kinase B (TrkB) receptors in NACsh neurons is necessary for cocaine-induced dendritic spine formation by using either localized TrkB knockout or viral-mediated expression of a dominant negative, kinase-dead TrkB mutant. Interestingly, augmenting wild-type TrkB expression after chronic cocaine self-administration reverses the sustained increase in dendritic spine density, an effect mediated by TrkB signaling pathways that converge on extracellular regulated kinase. Loss of TrkB function after cocaine self-administration, however, leaves spine density intact but markedly enhances the motivation for cocaine, an effect mediated by specific loss of TrkB signaling through phospholipase Cgamma1 (PLCγ1). Conversely, overexpression of PLCγ1 both reduces the motivation for cocaine and reverses dendritic spine density, suggesting a potential target for the treatment of addiction in chronic users. Together, these findings indicate that BDNF-TrkB signaling both mediates and reverses cocaine-induced increases in dendritic spine density in NACsh neurons, and these morphological changes are entirely dissociable from changes in addictive behavior.

scholarly journals Interaction of Ankycorbin and Tara regulates dendritic spine dynamics

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S344
Author(s):  
Soo Jeong Kim ◽  
Youngsik Woo ◽  
Su-Jin Noh ◽  
Yubin Won ◽  
Eun Byul Cho ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Spine Dynamics

Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion

Synapse ◽  
2009 ◽  
Vol 63 (12) ◽  
pp. 1143-1153 ◽  
Author(s):  
Oscar Solis ◽  
Rubén Antonio Vázquez-Roque ◽  
Israel Camacho-Abrego ◽  
Citlalli Gamboa ◽  
Fidel De La Cruz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Dendritic Spine ◽  
Spine Density ◽  
Amygdala Lesion ◽  
Dendritic Spine Density ◽  
Density Of Neurons

scholarly journals Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5

2014 ◽  
Vol 220 (4) ◽  
pp. 2415-2422 ◽  
Author(s):  
Brittni M. Peterson ◽  
Paul G. Mermelstein ◽  
Robert L. Meisel
Keyword(s):  
Nucleus Accumbens ◽  
Dendritic Spine ◽  
Nucleus Accumbens Core ◽  
Spine Plasticity ◽  
Accumbens Core

scholarly journals Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens

2009 ◽  
Vol 106 (8) ◽  
pp. 2915-2920 ◽  
Author(s):  
Yong Kim ◽  
Merilee A. Teylan ◽  
Matthew Baron ◽  
Adam Sands ◽  
Angus C. Nairn ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dendritic Spine ◽  
Spine Formation

scholarly journals Bergmann glial ensheathment of dendritic spines regulates synapse number without affecting spine motility

2010 ◽  
Vol 6 (3) ◽  
pp. 193-200 ◽  
Author(s):  
Jocelyn J. Lippman Bell ◽  
Tamar Lordkipanidze ◽  
Natalie Cobb ◽  
Anna Dunaevsky
Keyword(s):  
Purkinje Cell ◽  
Dendritic Spines ◽  
Dendritic Spine ◽  
Adenoviral Vector ◽  
Spine Density ◽  
Dendritic Spine Density ◽  
Spine Dynamics

In the cerebellum, lamellar Bergmann glial (BG) appendages wrap tightly around almost every Purkinje cell dendritic spine. The function of this glial ensheathment of spines is not entirely understood. The development of ensheathment begins near the onset of synaptogenesis, when motility of both BG processes and dendritic spines are high. By the end of the synaptogenic period, ensheathment is complete and motility of the BG processes decreases, correlating with the decreased motility of dendritic spines. We therefore have hypothesized that ensheathment is intimately involved in capping synaptogenesis, possibly by stabilizing synapses. To test this hypothesis, we misexpressed GluR2 in an adenoviral vector in BG towards the end of the synaptogenic period, rendering the BG α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) Ca2+-impermeable and causing glial sheath retraction. We then measured the resulting spine motility, spine density and synapse number. Although we found that decreasing ensheathment at this time does not alter spine motility, we did find a significant increase in both synaptic pucta and dendritic spine density. These results indicate that consistent spine coverage by BG in the cerebellum is not necessary for stabilization of spine dynamics, but is very important in the regulation of synapse number.

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