scholarly journals Runx1 protects against the pathological progression of osteoarthritis

Bone Research ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Chenchen Zhou ◽  
Yujia Cui ◽  
Yueyi Yang ◽  
Daimo Guo ◽  
Demao Zhang ◽  
...  
Keyword(s):  
Growth Plate ◽  
Cruciate Ligament ◽  
Bone Matrix ◽  
Cartilage Destruction ◽  
Vertebrate Development ◽  
Early Osteoarthritis ◽  
Adeno Associated Virus ◽  
Related Transcription Factor ◽  
Anterior Cruciate

AbstractRunt-related transcription factor-1 (Runx1) is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development. However, the potential role of Runx1 in joint diseases is not well known. In the current study, we aimed to explore the role of Runx1 in osteoarthritis induced by anterior cruciate ligament transaction (ACLT) surgery. We showed that chondrocyte-specific Runx1 knockout (Runx1f/fCol2a1-Cre) aggravated cartilage destruction by accelerating the loss of proteoglycan and collagen II in early osteoarthritis. Moreover, we observed thinning and ossification of the growth plate, a decrease in chondrocyte proliferative capacity and the loss of bone matrix around the growth plate in late osteoarthritis. We overexpressed Runx1 by adeno-associated virus (AAV) in articular cartilage and identified its protective effect by slowing the destruction of osteoarthritis in cartilage in early osteoarthritis and alleviating the pathological progression of growth plate cartilage in late osteoarthritis. ChIP-seq analysis identified new targets that interacted with Runx1 in cartilage pathology, and we confirmed the direct interactions of these factors with Runx1 by ChIP-qPCR. This study helps us to understand the function of Runx1 in osteoarthritis and provides new clues for targeted osteoarthritis therapy.

Acute and Chronic Tears of Anterior Cruciate Ligament: Role of Gadolinium-enhanced MR Imaging

1998 ◽  
Vol 39 (1) ◽  
pp. 163
Author(s):  
Eun Jung Lee ◽  
Won Hee Jee ◽  
Soo A Im ◽  
Ho Jong Chun ◽  
Hyun Seouk Jung ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Mr Imaging ◽  
Cruciate Ligament ◽  
Anterior Cruciate

Mechanical Simulation of Knee Movement in Basketball Shooting

2013 ◽  
Vol 336-338 ◽  
pp. 760-763
Author(s):  
Hui Yue
Keyword(s):  
Finite Element ◽  
Cruciate Ligament ◽  
Three Dimensional ◽  
Element Model ◽  
Basketball Player ◽  
Knee Movement ◽  
Dimensional Finite Element ◽  
Anterior Cruciate ◽  
Three Dimensional Finite Element

A short explanation of the finite element method as a powerful tool for mathematical modeling is provided, and an application using constitutive modeling of the behavior of ligaments is introduced. Few possible explanations of the role of water in ligament function are extracted from two dimensional finite element models of a classical ligament. The modeling is extended to a three dimensional finite element model for the human anterior cruciate ligament. Simulation of ligament force in pitching motion of basketball player is studied in this paper.

scholarly journals Detection of early osteoarthritis in canine knee joints 3 weeks post ACL transection by microscopic MRI and biomechanical measurement

2018 ◽  
Vol 26 (2) ◽  
pp. 230949901877835 ◽  
Author(s):  
Daniel Mittelstaedt ◽  
David Kahn ◽  
Yang Xia
Keyword(s):  
Cruciate Ligament ◽  
Canine Model ◽  
Quantitative Mri ◽  
Early Developmental Stage ◽  
Early Osteoarthritis ◽  
Biomechanical Stress ◽  
Magnetic Resonance Imaging Mri ◽  
Anterior Cruciate ◽  
Transverse Resolution ◽  
Acl Transection

Purpose: To detect early osteoarthritis (OA) in a canine Pond–Nuki model 3 weeks after anterior cruciate ligament (ACL) transection surgery, both topographically over the medial tibial surface and depth-dependently over the cartilage thickness. Methods: Four topographical locations on each OA and contralateral medial tibia were imaged individually by magnetic resonance imaging (MRI) at 17.6 µm transverse resolution. The quantitative MRI T2 relaxation data were correlated with the biomechanical stress-relaxation measurements from adjacent locations. Results: OA cartilage was thinner than the contralateral tissue and had a lower modulus compared to the contralateral cartilage for the exterior, interior, and central medial tibia locations. Depth-dependent and topographical variations were detected in OA cartilage by a number of parameters (compressive modulus, glycosaminoglycan concentration, bulk and zonal thicknesses, T2 at 0° and 55° specimen orientations in the magnet). T2 demonstrated significant differences at varying depths between OA and contralateral cartilage. Conclusion: ACL transection caused a number of changes in the tibial cartilage at 3 weeks after the surgery. The characteristics of these changes, which are topographic and depth-dependent, likely reflect the complex degradation in this canine model of OA at the early developmental stage.

Role of the anterolateral complex in rotatory instability of the anterior cruciate ligament deficient knee

2017 ◽  
Vol 2 ◽  
pp. 35-35
Author(s):  
Gian Andrea Lucidi ◽  
Jonathan D. Hughes ◽  
Elmar Herbst ◽  
Jeremy M. Burnham ◽  
Volker Musahl
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Rotatory Instability ◽  
Anterolateral Complex ◽  
Anterior Cruciate ◽  
Deficient Knee ◽  
Anterior Cruciate Ligament Deficient
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