A new portable measuring device for monitoring intraocular pressure with a non invasive system using a prototype of contact lens has been developed. The contact lens is based on a new organic flexible highly piezo-resisitive film sensor that is glued to the central hole of a lens. The measuring system is wire connected to the contact lens and incorporates user interface methods and a Bluetooth link for bi-directional wireless data transfer. The key design aspects of such architecture are discussed in this paper. The system is designed with an architecture that can be integrated in the future in order to be placed in the contact lens. The discrete system is used to validate the electronic measurement operation and the contact lens sensor (CLS). The measurement instrument can calibrate the differences of the nominal value of the sensor and measure resistances variations that are related to pressure variations. The measuring system and the contact lens sensor were tested with an eye phantom and with enucleated pig eyes by applying pressure changes between 7 to 32 mmHg recording the electrical changes with the portable device.