Three-dimensional tissue model in direct contact with an on-chip vascular bed enabled by removable membranes

Three-dimensional (3D) tissue culture is a powerful tool for understanding physiological events. However, 3D tissues still have limitations in their size, culture period, and maturity, which are caused by the...

A Novel Magnetophoretic-Based Device for Magnetometry and Separation of Single Magnetic Particles and Magnetized Cells

The use of magnetic micro- and nanoparticles in medicine and biology is expanding. One important example is the transport of magnetic microparticles and magnetized cells in lab-on-a-chip systems. The magnetic...

High-throughput concentration of rare malignant tumor cells from large-volume effusions by multistage inertial microfluidics

On-chip concentration of rare malignant tumor cells (MTCs) in malignant pleural effusions (MPEs) with a large volume is challenging. Previous microfluidic concentrators suffer from a low concentration factor (CF) and...

Correction: Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform

Correction for ‘Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform’ by Saba Goodarzi et al., Lab Chip, 2021, 21, 2495–2510, DOI: 10.1039/D1LC00192B.

Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

We report on a silicon microfluidic platform that enables integration of transparent μm-scale microfluidic channels, an on-chip pL-volume droplet generator, and a nano-electrospray ionization emitter that enables spatial and temporal phase separation for mass spectrometry analysis.

A fully integrated SNP genotyping system for hereditary hearing-loss detection

Hereditary hearing loss is one of the most common human neurosensory disorder, and there is a great need for early intervention methods such as genetically screening newborns. Single nucleotide polymorphisms...

A floating 5-µm-diameter needle-electrode on the tissue for damage-reduced chronic neuronal recording in mice

Microelectrode technology is essential in electrophysiology and has made contributions to neuroscience as well as to medical applications. However, it is necessary to minimize tissue damage associated with needle-like electrode...

Generation of droplets with adjustable chemical concentrations based on fixed potential induced-charge electro-osmosis

The effective control of the sample concentration within droplets is essential in a broad range of assays in chemistry and biochemistry. Here we provide an electric method for producing batches...