Engineered human blood–brain barrier microfluidic model for vascular permeability analyses

Nature Protocols ◽

10.1038/s41596-021-00635-w ◽

2022 ◽

Author(s):

Cynthia Hajal ◽

Giovanni S. Offeddu ◽

Yoojin Shin ◽

Shun Zhang ◽

Olga Morozova ◽

...

Keyword(s):

Vascular Permeability ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Download Full-text

Faculty Opinions recommendation of Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738105264.793575662 ◽

2020 ◽

Author(s):

Dan Rujescu ◽

Matthias Jung

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Pathogenic Mechanism ◽

Brain Barrier ◽

Download Full-text

What human blood-brain barrier models can tell us about BBB function and drug discovery?

Expert Opinion on Drug Discovery ◽

10.1080/17460441.2019.1646722 ◽

2019 ◽

Vol 14 (11) ◽

pp. 1113-1123 ◽

Author(s):

Lino Ferreira

Keyword(s):

Drug Discovery ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Download Full-text

Evaluation of Blood-Brain Barrier Integrity Using Vascular Permeability Markers: Evans Blue, Sodium Fluorescein, Albumin-Alexa Fluor Conjugates, and Horseradish Peroxidase

10.1007/7651_2020_316 ◽

2020 ◽

Author(s):

Bulent Ahishali ◽

Mehmet Kaya

Keyword(s):

Horseradish Peroxidase ◽

Vascular Permeability ◽

Blood Brain Barrier ◽

Brain Barrier ◽

Sodium Fluorescein ◽

Barrier Integrity ◽

Alexa Fluor ◽

Blood Brain ◽

Blood Brain Barrier Integrity

Download Full-text

Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)84595-7 ◽

1986 ◽

Vol 261 (14) ◽

pp. 6536-6541

Author(s):

T B Choi ◽

W M Pardridge

Keyword(s):

Human Brain ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Brain Capillaries ◽

Blood Brain ◽

Phenylalanine Transport

Download Full-text

The expression pattern of transporters and receptors regulating the efflux of amyloid β across human blood-brain barrier

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.2191 ◽

2017 ◽

Vol 381 ◽

pp. 776

Author(s):

Y. Sano ◽

F. Shimizu ◽

I. Eri ◽

Y. Takeshita ◽

T. Kanda

Keyword(s):

Expression Pattern ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Download Full-text

Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-17-0983 ◽

2017 ◽

Vol 23 (24) ◽

pp. 7454-7466 ◽

Author(s):

Jing Li ◽

Jianmei Wu ◽

Xun Bao ◽

Norissa Honea ◽

Youming Xie ◽

...

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Pbpk Modeling ◽

Modeling Approach ◽

Blood Brain ◽

Mechanistic Understanding

Download Full-text

A Prediction Method for P-glycoprotein–Mediated Drug–Drug Interactions at the Human Blood–Brain Barrier From Blood Concentration–Time Profiles, Validated With PET Data

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.03.024 ◽

2017 ◽

Vol 106 (9) ◽

pp. 2780-2786 ◽

Author(s):

Akihiro Matsuda ◽

Rudolf Karch ◽

Martin Bauer ◽

Alexander Traxl ◽

Markus Zeitlinger ◽

...

Keyword(s):

Drug Interactions ◽

Blood Brain Barrier ◽

Human Blood ◽

Blood Concentration ◽

Prediction Method ◽

Brain Barrier ◽

Time Profiles ◽

Concentration Time ◽

P Glycoprotein ◽

Download Full-text

Efflux Pump Substrates Shuttled to Cytosolic or Vesicular Compartments Exhibit Different Permeability in a Quantitative Human Blood–Brain Barrier Model

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.8b00662 ◽

2018 ◽

Vol 15 (11) ◽

pp. 5081-5088 ◽

Author(s):

John S. Ruano-Salguero ◽

Kelvin H. Lee

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Efflux Pump ◽

Brain Barrier ◽

Blood Brain ◽

Blood Brain Barrier Model ◽

Download Full-text

Phenylalanine Transport at the Human Blood-Brain Barrier

Dietary Phenylalanine and Brain Function ◽

10.1007/978-1-4615-9821-3_5 ◽

1988 ◽

pp. 55-62 ◽

Author(s):

William M. Pardridge

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Blood Brain ◽

Phenylalanine Transport

Download Full-text

Prenatal Development of the Human Blood-Brain Barrier

Mammalian Brain Development ◽

10.1007/978-1-60761-287-2_4 ◽

2009 ◽

pp. 53-75 ◽

Author(s):

Luca Cucullo

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Prenatal Development ◽

Brain Barrier ◽

Download Full-text