scholarly journals The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ella Nissan ◽  
Uri Amit ◽  
Leo Baron ◽  
Amit Zabatani ◽  
Damien Urban ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Clinical Management ◽  
Primary Site ◽  
Unknown Primary ◽  
Histological Subtype ◽  
Unknown Primary Site ◽  
Cup Syndrome ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

AbstractWe assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated the identification of primary tumor (PT) by [18F]FDG-PET/CT, according to histological subtype, and the impact on clinical management. The median age was 65 years, 36/64 males (56%). PTs were detected in 28/64 (44%) patients. Detection was significantly lower in patients with squamous cell carcinoma (SCC) than with other histologies combined, p = 0.034. Mean age, mean SUVmax (10.6 ± 6.0) and organ involvement were similar between patients with and without discovered PTs; and between patients with SCC and with other histologies combined. However, those with SCC were less likely than the others to present with multi-lesion involvement, p < 0.001. [18F]FDG-PET/CT interpretations apparently affected treatment of 8/28 (29%) patients with PT detected, and in none of the 35 whose PT was not discovered, p < 0.001. [18F]FDG-PET/CT appeared helpful in detecting PT in almost half the patients with CUP syndrome; the lowest rate was for patients with SCC pathology. PET/CT showed limited overall value in guiding clinical management, however benefited those with discovered PT.

scholarly journals 18 F‐FDG PET/CT as a Diagnostic Tool in Patients with Extracervical Carcinoma of Unknown Primary Site: A Literature Review

2011 ◽  
Vol 16 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Anne Kirstine Hundahl Moller ◽  
Annika Loft ◽  
Anne Kiil Berthelsen ◽  
Karen Damgaard Pedersen ◽  
Jesper Graff ◽  
...  
Keyword(s):  
Literature Review ◽  
Diagnostic Tool ◽  
Fdg Pet ◽  
Primary Site ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Carcinoma Of Unknown Primary ◽  
Pet Ct ◽  
Fdg Pet Ct

A Stepwise Approach to Identify the Clinical Role of 18F-FDG PET/CT in Patients With Suspicious Bone Metastasis From an Unknown Primary Site

2019 ◽  
Vol 44 (9) ◽  
pp. e524-e525 ◽  
Author(s):  
Md. Sunny Anam Chowdhury ◽  
Subin Jeon ◽  
Hee-Seung Bom ◽  
Jung-Joon Min ◽  
Seong Young Kwon
Keyword(s):  
Bone Metastasis ◽  
Primary Site ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Clinical Role ◽  
Stepwise Approach ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Clinical Impact of F-18 FDG PET-CT on Biopsy Site Selection in Patients with Suspected Bone Metastasis of Unknown Primary Site

2020 ◽  
Vol 54 (4) ◽  
pp. 192-198
Author(s):  
Su Woong Yoo ◽  
Md. Sunny Anam Chowdhury ◽  
Subin Jeon ◽  
Sae-Ryung Kang ◽  
Changho Lee ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Site Selection ◽  
Fdg Pet ◽  
Clinical Impact ◽  
Primary Site ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Biopsy Site ◽  
Pet Ct ◽  
Fdg Pet Ct

The value of 18F-fluordesoxyglucose positron emission tomography (FDG-PET/CT) in the detection of the primary lesion and for staging in brain metastasis (BM) patients with cancer of unknown primary site (CUPS).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 2076-2076
Author(s):  
Emilie Le Rhun ◽  
Michael Weller ◽  
Anna Sophie Berghoff ◽  
Elisabeth Jane Rushing ◽  
Lisa Fuereder ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Cancer Of Unknown Primary ◽  
Primary Lesion ◽  
Primary Site ◽  
Emission Tomography ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Positron Emission ◽  
Pet Ct ◽  
Fdg Pet Ct

2076 Background: Brain metastasis (BM) are the first clinical presentation of cancer in around 30% of patients. They are then referred as BM from cancer of unknown primary site (BM-CUPS). The value of 18F-fluordesoxyglucose positron emission tomography (FDG-PET)/CT has not yet be determined for the management of these patients. Methods: A total of 566 patients were operated for BM at the University Hospital Zurich between 2004 and 2014, of whom 127 were identified as BM-CUPS patients. Two cohorts from other independent centers (n = 100 and 120) were used for the validation of data. Results: No difference in determining the localization of the primary lesion was observed between FDG-PET/CT and CT (FDG-PET/CT: 73/78, 93.6%; CT: n = 70/78, 89.7%; p = 0.25, McNemar’s test). The same pattern of primary lesion and other extracranial lesions was observed in 36 of 64 patients (56.3%). Additional suspicious extracranial metastases were identified by FDG-PET/CT in 28 patients (43.7%). The median graded prognostic assessment (GPA) scores were 2.5 determined according to FDG-PET/CT and 3 according to CT alone (p = 3.8x10-5), resulting in predicted survival times of 3.8 versus 5.3 months (p = 6.1x10-5; Wilcoxon’s test). Conclusions: A similar sensitivity of FDG-PET/CT and chest CT was observed for the detection of the primary tumor in BM-CUPS, however, FDG-PET/CT significantly improved the accuracy of staging. FDG-PET/CT should be preferred for the management of BM-CUPS and may help to avoid redundant CT imaging.

scholarly journals CMET-26. DIAGNOSTIC VALUE OF FDG-PET/CT FOR PATIENTS WITH BRAIN METASTASIS FROM UNKNOWN PRIMARY SITE

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi44-vi44
Author(s):  
Fabian Wolpert ◽  
Michael Weller ◽  
Anna Sophie Berghoff ◽  
Elisabeth Jane Rushing ◽  
Lisa Michaela Füreder ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Fdg Pet ◽  
Diagnostic Value ◽  
Primary Site ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Pet Ct ◽  
Fdg Pet Ct
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