scholarly journals Prepulse inhibition predicts subjective hearing in rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Naoki Wake ◽  
Kotaro Ishizu ◽  
Taiki Abe ◽  
Hirokazu Takahashi
Keyword(s):  
Cerebral Cortex ◽  
Prepulse Inhibition ◽  
Auditory Brainstem Response ◽  
Pure Tone ◽  
Wistar Rats ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Top Down ◽  
Brainstem Response ◽  
Hearing Assessment

AbstractAuditory studies in animals benefit from quick and accurate audiometry. The auditory brainstem response (ABR) and prepulse inhibition (PPI) have been widely used for hearing assessment in animals, but how well these assessments predict subjective audiometry still remains unclear. Human studies suggest that subjective audiometry is consistent with the ABR-based audiogram, not with the PPI-based audiogram, likely due to top-down processing in the cortex that inhibits PPI. Here, we challenged this view in Wistar rats, as rodents exhibit less complexity of cortical activities and thereby less influence of the cerebral cortex on PPI compared to humans. To test our hypothesis, we investigated whether subjective audiometry correlates with ABR- or PPI-based audiograms across the range of audible frequencies in Wistar rats. The subjective audiogram was obtained through pure-tone audiometry based on operant conditioning. Our results demonstrated that both the ABR-based and PPI-based audiograms significantly correlated to the subjective audiogram. We also found that ASR strength was information-rich, and adequate interpolation of this data offered accurate audiometry. Thus, unlike in humans, PPI could be used to predict subjective audibility in rats.

Investigations in ENT

2009 ◽  
pp. 53-72
Author(s):  
Rogan Corbridge ◽  
Nicholas Steventon
Keyword(s):  
Ct Scan ◽  
Auditory Brainstem Response ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Common Method ◽  
Mri Scan ◽  
Brainstem Response ◽  
Hearing Assessment

Pure tone audiometry (PTA) 54 Tympanometry 56 Otoacoustic emissions (OAEs) 60 Auditory brainstem response (ABR) 62 ENG and calorics 64 Calorics 65 Children’s hearing assessment 66 CT scan 67 MRI scan 68 Allergy testing 70 This is the most common method used for assessing hearing. The examination will ideally take place in a soundproof booth. To avoid cheating, the patient should not be able to see the audiometer controls....

The effect of coronavirus disease 2019 on the hearing system

2021 ◽  
pp. 1-5
Author(s):  
Ö Gedik ◽  
H Hüsam ◽  
M Başöz ◽  
N Tas ◽  
F Aksoy
Keyword(s):  
Auditory Brainstem Response ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Brainstem Response ◽  
Hearing System

Abstract Objective This study aimed to evaluate different auditory regions with audiological tests, based on the presumption that there may be damage to the structures in the hearing system after coronavirus disease 2019. Methods Twenty individuals with no history of coronavirus disease 2019 and 27 individuals diagnosed with coronavirus disease 2019 were compared. Pure tone, speech and extended high-frequency audiometry, acoustic immitansmetry, transient evoked and distortion product otoacoustic emissions testing, and auditory brainstem response testing were conducted. Results The pure tone audiometry and extended high-frequency mean threshold values were higher in the coronavirus disease 2019 group. The transient evoked otoacoustic emissions signal-to-noise ratios were bilaterally lower at 4 kHz in individuals with a coronavirus disease 2019 history. In the auditory brainstem response test, only the interpeak latencies of waves III–V were significantly different between groups. Conclusion Coronavirus disease 2019 may cause damage to the hearing system. Patients should be followed up in the long term with advanced audiological evaluation methods in order to determine the extent and level of damage.

scholarly journals A Survey on Auditory Brainstem Response and Pure Tone Audiometry Modalities in Mobile Phone Users

2020 ◽  
Vol 28 (126) ◽  
pp. 54-63
Author(s):  
Mehdi Maghbooli ◽  
Kasra Akbari ◽  
Nooshin Allamehzadeh ◽  
Alireza Jandaneh ◽  
◽  
...  
Keyword(s):  
Mobile Phone ◽  
Auditory Brainstem Response ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Brainstem Response

Normal Brief-Tone Bone-Conduction Behavioral Thresholds Using the B-71 Transducer: Three Occlusion Conditions

2003 ◽  
Vol 14 (10) ◽  
pp. 556-562 ◽  
Author(s):  
Susan A. Small ◽  
David R. Stapells
Keyword(s):  
Auditory Brainstem Response ◽  
Pure Tone ◽  
Bone Conduction ◽  
Auditory Brainstem ◽  
Behavioral Thresholds ◽  
Brainstem Response ◽  
Occlusion Effect ◽  
Response Testing ◽  
Brief Tones ◽  
Air Conduction

Behavioral thresholds were measured from 31 adults with normal hearing for 500, 1000, 2000, and 4000 Hz brief tones presented using a B-71 bone oscillator. Three occlusion conditions were assessed: ears unoccluded, one ear occluded, and both ears occluded. Mean threshold force levels were 67, 54, 49, and 41 dB re:1μN peak-to-peak equivalent in the unoccluded condition for 500, 1000, 2000, and 4000 Hz, respectively (corrected for air-conduction pure-tone thresholds). A significant occlusion effect was observed for 500 and 1000 Hz stimuli. These thresholds may be used as the 0 dB nHL (normalhearing level) for brief-tone bone-conduction stimuli for auditory brainstem response testing.

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