scholarly journals Pure red cell aplasia after a major ABO-mismatched bone marrow transplant for chronic myeloid leukaemia: response to re-introduction of cyclosporin

2003 ◽  
Vol 33 (4) ◽  
pp. 459-461 ◽  
Author(s):  
P J Hayden ◽  
N Gardiner ◽  
K Molloy ◽  
J Ryan ◽  
M Lawler ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Bone Marrow Transplant ◽  
Pure Red Cell Aplasia ◽  
Marrow Transplant ◽  
Red Cell ◽  
Red Cell Aplasia

scholarly journals Pure red cell aplasia of long duration complicating major ABO- incompatible bone marrow transplantation [see comments]

Blood ◽  
1990 ◽  
Vol 75 (1) ◽  
pp. 290-295 ◽  
Author(s):  
JP Gmur ◽  
J Burger ◽  
A Schaffner ◽  
K Neftel ◽  
O Oelz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Leukocyte ◽  
Pure Red Cell Aplasia ◽  
Marrow Transplant ◽  
Red Cell ◽  
Antibody Synthesis ◽  
Leukocyte Antigen ◽  
Red Cell Aplasia ◽  
Long Duration ◽  
Very High

Abstract In 3 of 15 consecutive patients receiving a human leukocyte antigen (HLA)-identical but major ABO incompatible bone marrow transplant (BMT), pure red cell aplasia (PRA) lasting 5 to 8 months was observed. Titers of the incompatible anti-A agglutinin before infusion of the red blood cell (RBC)-depleted BMT was very high in one, and in the usual range in two patients. Decrease of agglutinin titers during the first 4 weeks after BMT were comparable between PRA patients and those of ABO- incompatible BMT recipients with timely RBC recovery. However, in PRA patients, agglutinin titers rose again and remained elevated for 19 to 28 weeks. RBC engraftment and reticulocyte recovery ultimately occurred spontaneously and coincided with the decrease of agglutinin titers below 16. These observations indicate that PRA is antibody-dependent in this setting. Furthermore, it is conceivable that cyclosporine facilitates recipient-derived antibody synthesis after major ABO- incompatible BMT.

scholarly journals Pure red cell aplasia of long duration complicating major ABO- incompatible bone marrow transplantation [see comments]

Blood ◽  
1990 ◽  
Vol 75 (1) ◽  
pp. 290-295 ◽  
Author(s):  
JP Gmur ◽  
J Burger ◽  
A Schaffner ◽  
K Neftel ◽  
O Oelz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Leukocyte ◽  
Pure Red Cell Aplasia ◽  
Marrow Transplant ◽  
Red Cell ◽  
Antibody Synthesis ◽  
Leukocyte Antigen ◽  
Red Cell Aplasia ◽  
Long Duration ◽  
Very High

In 3 of 15 consecutive patients receiving a human leukocyte antigen (HLA)-identical but major ABO incompatible bone marrow transplant (BMT), pure red cell aplasia (PRA) lasting 5 to 8 months was observed. Titers of the incompatible anti-A agglutinin before infusion of the red blood cell (RBC)-depleted BMT was very high in one, and in the usual range in two patients. Decrease of agglutinin titers during the first 4 weeks after BMT were comparable between PRA patients and those of ABO- incompatible BMT recipients with timely RBC recovery. However, in PRA patients, agglutinin titers rose again and remained elevated for 19 to 28 weeks. RBC engraftment and reticulocyte recovery ultimately occurred spontaneously and coincided with the decrease of agglutinin titers below 16. These observations indicate that PRA is antibody-dependent in this setting. Furthermore, it is conceivable that cyclosporine facilitates recipient-derived antibody synthesis after major ABO- incompatible BMT.

PURE RED CELL APLASIA : A CASE REPORT

2021 ◽  
pp. 55-56
Author(s):  
G Srivani ◽  
D Roja Aishwarya ◽  
P. V. S. Kiran
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Failure ◽  
Bone Marrow Aspiration ◽  
Oral Prednisolone ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia ◽  
Normocytic Normochromic Anemia ◽  
Pure Cell ◽  
Normochromic Anemia

Pure cell aplasia is a rare bone marrow failure that affects erythroid lineage characterized by normocytic normochromic anemia with reticulocytopenia in the peripheral blood and absent or infrequent erythroblasts in the bone marrow. It can be congenital or acquired. Acquired can be primary when no cause is identied or secondary-due to underlying or associated pathology. Herein we report a case of a 28 year old female with Primary Acquired Pure Red cell aplasia. The patient presented with severe anemia (Hb-1.9gm%) and low reticulocyte count 0.1%. Bone marrow aspiration shows normocellular marrow with Decreased erythropoiesis with M:E ratio of 20:1..Patient was started on oral prednisolone and improvement was seen and the patient became transfusion independent.

Anemia: Production Defects Generally Associated with Marrow Aplasia or Replacement

2017 ◽  
Author(s):  
Nancy Berliner ◽  
John M Gansner
Keyword(s):  
Bone Marrow ◽  
Differential Diagnosis ◽  
Aplastic Anemia ◽  
Blood Smear ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Red Cell Aplasia

This review focuses on anemia resulting from production defects generally associated with marrow aplasia or replacement. The definition, epidemiology, etiology, pathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis of the following production defects are discussed: Acquired aplastic anemia and acquired pure red cell aplasia. Figures depict a leukoerythroblastic blood smear, a biopsy comparing normal bone marrow and bone marrow showing almost complete aplasia, and a marrow smear. A table lists the causes of aplastic anemia. This review contains 3 figures; 1 table; 108 references.

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