Neurochemical, Electrophysiological and Pharmacological Profiles of the Selective Inhibitor of the Glycine Transporter-1 SSR504734, a Potential New Type of Antipsychotic

Ronan Depoortère; Gihad Dargazanli; Genevieve Estenne-Bouhtou; Annick Coste; Christophe Lanneau; Christophe Desvignes; Martine Poncelet; Michel Heaulme; Vincent Santucci; Michel Decobert; Annie Cudennec; Carolle Voltz; Denis Boulay; Jean Paul Terranova; Jeanne Stemmelin; Pierre Roger; Benoit Marabout; Mireille Sevrin; Xavier Vigé; Bruno Biton; Régis Steinberg; Dominique Françon; Richard Alonso; Patrick Avenet; Florence Oury-Donat; Ghislaine Perrault; Guy Griebel; Pascal George; Philippe Soubrié; Bernard Scatton

doi:10.1038/sj.npp.1300772

Neurochemical, Electrophysiological and Pharmacological Profiles of the Selective Inhibitor of the Glycine Transporter-1 SSR504734, a Potential New Type of Antipsychotic

Neuropsychopharmacology ◽

10.1038/sj.npp.1300772 ◽

2005 ◽

Vol 30 (11) ◽

pp. 1963-1985 ◽

Cited By ~ 169

Author(s):

Ronan Depoortère ◽

Gihad Dargazanli ◽

Genevieve Estenne-Bouhtou ◽

Annick Coste ◽

Christophe Lanneau ◽

...

Keyword(s):

Selective Inhibitor ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

New Type ◽

Pharmacological Profiles

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Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia☆

Pharmacology Biochemistry and Behavior ◽

10.1016/j.pbb.2008.06.009 ◽

2008 ◽

Vol 91 (1) ◽

pp. 47-58 ◽

Cited By ~ 67

Author(s):

D BOULAY ◽

P PICHAT ◽

G DARGAZANLI ◽

G ESTENNEBOUHTOU ◽

J TERRANOVA ◽

...

Keyword(s):

Selective Inhibitor ◽

Therapeutic Activity ◽

Glycine Transporter 1 ◽

Glycine Transporter

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A Highly Selective Inhibitor of Glycine Transporter-1 Elevates the Threshold for Maximal Electroshock-Induced Tonic Seizure in Mice

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b15-00501 ◽

2016 ◽

Vol 39 (2) ◽

pp. 174-180 ◽

Cited By ~ 5

Author(s):

Jianghao Zhao ◽

Hua Tao ◽

Wenchuan Xian ◽

Yujie Cai ◽

Wanwen Cheng ◽

...

Keyword(s):

Selective Inhibitor ◽

Maximal Electroshock ◽

Tonic Seizure ◽

Glycine Transporter 1 ◽

Glycine Transporter

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Effects of Antipsychotic Drugs on Glycine Transporter 1 Protein Expression

PsycEXTRA Dataset ◽

10.1037/e617962012-180 ◽

2008 ◽

Author(s):

Brian Hoffman ◽

Mark E. Bardgett

Keyword(s):

Protein Expression ◽

Antipsychotic Drugs ◽

Glycine Transporter 1 ◽

Glycine Transporter

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Glycine transporter 1 inhibitors may exert neuroprotective effects in hypoxic retina

Intrinsic Activity ◽

10.25006/ia.4.s3-a4.19 ◽

2016 ◽

Vol 4 (Suppl. 3) ◽

pp. A1.19

Author(s):

László G. Hársing, Jr.

Keyword(s):

Neuroprotective Effects ◽

Glycine Transporter 1 ◽

Glycine Transporter

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Glycine Reuptake Inhibition as a New Therapeutic Approach in Schizophrenia: Focus on the Glycine Transporter 1 (GlyT1)

Current Pharmaceutical Design ◽

10.2174/1381612811319070015 ◽

2012 ◽

Vol 19 (7) ◽

pp. 1311-1320 ◽

Cited By ~ 1

Author(s):

Pierre Chue

Keyword(s):

Therapeutic Approach ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

Reuptake Inhibition

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Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2006.12.010 ◽

2007 ◽

Vol 31 (3) ◽

pp. 642-651 ◽

Cited By ~ 66

Author(s):

Yasuyuki Iwamoto ◽

Shigeru Morinobu ◽

Terumichi Takahashi ◽

Shigeto Yamawaki

Keyword(s):

Membrane Protein ◽

Single Prolonged Stress ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

Prolonged Stress

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The synthesis and preclinical evaluation in rhesus monkey of [18F]MK-6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Synapse ◽

10.1002/syn.20842 ◽

2011 ◽

Vol 65 (4) ◽

pp. 261-270 ◽

Cited By ~ 29

Author(s):

Terence G. Hamill ◽

Waisi Eng ◽

Andrew Jennings ◽

Richard Lewis ◽

Steven Thomas ◽

...

Keyword(s):

Positron Emission Tomography ◽

Rhesus Monkey ◽

Emission Tomography ◽

Preclinical Evaluation ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

Positron Emission

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Gene Knockout of Glycine Transporter 1: Characterization of the Behavioral Phenotype

Yearbook of Psychiatry and Applied Mental Health ◽

10.1016/s0084-3970(08)70274-3 ◽

2006 ◽

Vol 2006 ◽

pp. 281-282

Author(s):

P.F. Buckley

Keyword(s):

Gene Knockout ◽

Behavioral Phenotype ◽

Glycine Transporter 1 ◽

Glycine Transporter

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Glycine transporter-1 regulates the proliferation of neural stem/progenitor cells derived from the embryonic mouse hippocampus

Global Drugs and Therapeutics ◽

10.15761/gdt.1000s1007 ◽

2017 ◽

Vol 2 (5) ◽

Author(s):

Masanori Yoneyama ◽

Kiyokazu Ogita ◽

Taro Yamaguchi ◽

Yusuke Onaka

Keyword(s):

Progenitor Cells ◽

Embryonic Mouse ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

Mouse Hippocampus ◽

Neural Stem Progenitor Cells

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Glycine Transporter 1 Inhibitors and Modulation of NMDA Receptor-Mediated Excitatory Neurotransmission

Current Drug Targets ◽

10.2174/138945007780618535 ◽

2007 ◽

Vol 8 (5) ◽

pp. 643-649 ◽

Cited By ~ 44

Author(s):

Cyrille Sur ◽

Gene Kinney

Keyword(s):

Nmda Receptor ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

Excitatory Neurotransmission

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