scholarly journals Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells

Oncogene ◽  
2003 ◽  
Vol 22 (32) ◽  
pp. 4964-4972 ◽  
Author(s):  
Ying Chen ◽  
Debora L Kramer ◽  
Fengzhi Li ◽  
Carl W Porter
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Proteins ◽  
Human Melanoma Cells ◽  
Polyamine Analog ◽  
Induced Apoptosis ◽  
Apoptosis Proteins

scholarly journals Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.

1993 ◽  
Vol 268 (25) ◽  
pp. 19118-19125
Author(s):  
M. Fogel-Petrovic ◽  
N.W. Shappell ◽  
R.J. Bergeron ◽  
C.W. Porter
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Polyamine Analog

Suppression of W Damage-Induced Apoptosis of Human Melanoma Cells by a Fermented Milk, Kefir

2005 ◽  
pp. 385-389
Author(s):  
Junko Narisawa ◽  
Tsutomu Nagira ◽  
Ken-ichi Kusumoto ◽  
Kiichiro Teruya ◽  
Yoshinori Katakura ◽  
...  
Keyword(s):  
Fermented Milk ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Induced Apoptosis

scholarly journals Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins.

1997 ◽  
Vol 17 (5) ◽  
pp. 2835-2843 ◽  
Author(s):  
A J Harvey ◽  
A P Bidwai ◽  
L K Miller
Keyword(s):  
Insect Cells ◽  
Cysteine Proteases ◽  
Carboxyl Terminus ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Proteins ◽  
Induction Of Apoptosis ◽  
Apoptotic Pathways ◽  
Induced Apoptosis ◽  
Apoptosis Proteins

A family of baculovirus inhibitor-of-apoptosis (IAP) genes is present in mammals, insects, and baculoviruses, but the mechanism by which they block apoptosis is unknown. We have identified a protein encoded by the Drosophila mod(mdg4) gene which bound to the baculovirus IAPs. This protein induced rapid apoptosis in insect cells, and consequently we have named it Doom. Baculovirus IAPs and P35, an inhibitor of aspartate-specific cysteine proteases, blocked Doom-induced apoptosis. The carboxyl terminus encoded by the 3' exon of the doom cDNA, which distinguishes it from other mod(mdg4) cDNAs, was responsible for induction of apoptosis and engagement of the IAPs. Doom localized to the nucleus, while the IAPs localized to the cytoplasm, but when expressed together, Doom and the IAPs both localized in the nucleus. Thus, IAPs might block apoptosis by interacting with and modifying the behavior of Doom-like proteins that reside in cellular apoptotic pathways.

scholarly journals Targeting inhibitor of apoptosis proteins in combination with dacarbazine or TRAIL in melanoma cells

2011 ◽  
Vol 12 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Birgit Ø. Engesæter ◽  
Menaka Sathermugathevan ◽  
Tina Hellenes ◽  
Olav Engebråten ◽  
Ruth Holm ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Proteins ◽  
Apoptosis Proteins

scholarly journals Ribozyme-mediated attenuation of survivin expression sensitizes human melanoma cells to cisplatin-induced apoptosis

2002 ◽  
Vol 109 (2) ◽  
pp. 285-286 ◽  
Author(s):  
Marzia Pennati ◽  
Gennaro Colella ◽  
Marco Folini ◽  
Lorenzo Citti ◽  
Maria Grazia Daidone ◽  
...  
Keyword(s):  
Survivin Expression ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Induced Apoptosis

Abstract 2940: Statin induced apoptosis in human melanoma cells is prevented by inhibition of caspase 2 and translational activity.

2013 ◽  
Author(s):  
Christoph Minichsdorfer ◽  
Christine Wasinger ◽  
Evelyn Sieczkowski ◽  
Atil Bihter ◽  
Gerwin Heller ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Translational Activity ◽  
Human Melanoma Cells ◽  
Caspase 2 ◽  
Induced Apoptosis
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