scholarly journals Erratum: Corrigendum: Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yunan Wang ◽  
Abudurexiti Kayoumu ◽  
Guotao Lu ◽  
Pengfei Xu ◽  
Xu Qiu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Golden Hamster ◽  
Experimental Models ◽  
Syrian Golden Hamster ◽  
Human Acute Pancreatitis

scholarly journals Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yunan Wang ◽  
Abudurexiti Kayoumu ◽  
Guotao Lu ◽  
Pengfei Xu ◽  
Xu Qiu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Necrotizing Pancreatitis ◽  
Sodium Taurocholate ◽  
Concomitant Administration ◽  
Inflammatory Cells ◽  
Neutrophil Infiltration ◽  
Pancreatic Injury ◽  
Experimental Models ◽  
Myeloperoxidase Activity ◽  
Human Acute Pancreatitis

Abstract The hamster has been shown to share a variety of metabolic similarities with humans. To replicate human acute pancreatitis with hamsters, we comparatively studied the efficacy of common methods, such as the peritoneal injections of caerulein, L-arginine, the retrograde infusion of sodium taurocholate, and another novel model with concomitant administration of ethanol and fatty acid. The severity of pancreatitis was evaluated by serum amylase activity, pathological scores, myeloperoxidase activity, and the expression of inflammation factors in pancreas. The results support that the severity of pathological injury is consistent with the pancreatitis induced in mice and rat using the same methods. Specifically, caerulein induced mild edematous pancreatitis accompanied by minimal lung injury, while L-arginine induced extremely severe pancreatic injury including necrosis and neutrophil infiltration. Infusion of Na-taurocholate into the pancreatic duct induced necrotizing pancreatitis in the head of pancreas and lighter inflammation in the distal region. The severity of acute pancreatitis induced by combination of ethanol and fatty acids was between the extent of caerulein and L-arginine induction, with obvious inflammatory cells infiltration. In view of the advantages in lipid metabolism features, hamster models are ideally suited for the studies of pancreatitis associated with altered metabolism in humans.

Dietary manipulation of ethanol preference in the Syrian Golden hamster

1986 ◽  
Vol 25 (6) ◽  
pp. 1285-1292 ◽  
Author(s):  
S.C. Cunnane ◽  
Y.-S. Huang ◽  
D.F. Horrobin
Keyword(s):  
Golden Hamster ◽  
Syrian Golden Hamster ◽  
Dietary Manipulation ◽  
Ethanol Preference

scholarly journals Acute Toxicity of Tri-n-Butyltin Chloride(TBTC) in the Syrian Golden Hamster.

1992 ◽  
Vol 166 (3) ◽  
pp. 309-319 ◽  
Author(s):  
SHUKO TAKAGI ◽  
HIROSHI MANO ◽  
MASASHI TSUNODA ◽  
HIROTO NAKADAIRA ◽  
KAZUO ENDOH ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Golden Hamster ◽  
Syrian Golden Hamster

The HaP-T1 Syrian Golden Hamster Pancreatic Cancer Model

Pancreas ◽  
2004 ◽  
Vol 29 (4) ◽  
pp. 320-323 ◽  
Author(s):  
Ajit T. Abraham ◽  
Sudeep R. Shah ◽  
Brian R. Davidson
Keyword(s):  
Pancreatic Cancer ◽  
Golden Hamster ◽  
Syrian Golden Hamster ◽  
Cancer Model

scholarly journals Ca 2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview

2016 ◽  
Vol 371 (1700) ◽  
pp. 20150425 ◽  
Author(s):  
József Maléth ◽  
Péter Hegyi
Keyword(s):  
Acute Pancreatitis ◽  
Mitochondrial Permeability Transition ◽  
Clinical Investigation ◽  
Cell Damage ◽  
Specific Treatment ◽  
Experimental Models ◽  
Mitochondrial Damage ◽  
Cell Functions ◽  
Cellular Ca

Acute pancreatitis (AP) is a leading cause of hospitalization among non-malignant gastrointestinal disorders. The mortality of severe AP can reach 30–50%, which is most probably owing to the lack of specific treatment. Therefore, AP is a major healthcare problem, which urges researchers to identify novel drug targets. Studies from the last decades highlighted that the toxic cellular Ca 2+ overload and mitochondrial damage are key pathogenic steps in the disease development affecting both acinar and ductal cell functions. Moreover, recent observations showed that modifying the cellular Ca 2+ signalling might be beneficial in AP. The inhibition of Ca 2+ release from the endoplasmic reticulum or the activity of plasma membrane Ca 2+ influx channels decreased the severity of AP in experimental models. Similarly, inhibition of mitochondrial permeability transition pore (MPTP) opening also seems to improve the outcome of AP in in vivo animal models. At the moment MPTP blockers are under detailed clinical investigation to test whether interventions in MPTP openings and/or Ca 2+ homeostasis of the cells can be specific targets in prevention or treatment of cell damage in AP. This article is part of the themed issue ‘Evolution brings Ca 2+ and ATP together to control life and death’.

Behavioral Development in the Syrian Golden Hamster

The Hamster ◽  
1985 ◽  
pp. 289-321 ◽  
Author(s):  
Thomas A. Schoenfeld ◽  
Christiana M. Leonard
Keyword(s):  
Golden Hamster ◽  
Behavioral Development ◽  
Syrian Golden Hamster

Local and Systemic Zymogen Activation in Human Acute Pancreatitis

Digestion ◽  
2000 ◽  
Vol 62 (2-3) ◽  
pp. 164-170 ◽  
Author(s):  
Jens M. Mayer ◽  
Bettina Rau ◽  
Marco Siech ◽  
Hans G. Beger
Keyword(s):  
Acute Pancreatitis ◽  
Zymogen Activation ◽  
Human Acute Pancreatitis

Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by guinea pig and syrian golden hamster

Chemosphere ◽  
1986 ◽  
Vol 15 (4) ◽  
pp. 519-533 ◽  
Author(s):  
Martin van den Berg ◽  
Erik de Vroom ◽  
Kees Olie ◽  
O. Hutzinger
Keyword(s):  
Fly Ash ◽  
Guinea Pig ◽  
Golden Hamster ◽  
Syrian Golden Hamster ◽  
Oral Ingestion
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