Sex-specific effect of maternal thyroid hormone trajectories on preschoolers’ behavioral development: a birth cohort study

Context Maternal thyroid hormone trajectories are better predictor of offspring’s neurodevelopment than hormone levels in single trimester of pregnancy. Programming effect of uterine hormonal environment on offspring’s health is usually sex-specific. Objective To examine the sex-specific effect of thyroid hormone trajectories on preschoolers’ behavioral development. Design Based on Ma’ anshan Birth Cohort (MABC) in China, pregnant women were recruited at their first antenatal checkup from May 2013 to September 2014. Setting Ma’ anshan Maternal and Child Health Hospital in China. Patients or Other Participants 1860 mother-child pairs were included in the analysis. Children were followed up at age of 4. Main Outcome Measures Maternal thyroid hormones (TSH, FT4) and TPOAb in the first, second and third trimesters of pregnancy were retrospectively assayed. Preschoolers’ behavioral development was assessed by Achenbach Child Behavior Checklist (CBCL/1.5~5). Results Maternal TSH and FT4 levels were respectively fitted into high, moderate and low trajectories. In boys, maternal high TSH trajectory was related to withdrawn (OR = 2.01, 95% CI: 1.16, 3.50) and externalizing problems (OR = 2.69, 95% CI: 1.22, 5.92), and moderate TSH trajectory was associated with aggressive behavior (OR = 3.76, 95% CI: 1.16, 12.23). Maternal high FT4 trajectory was associated with anxious/depressed (OR = 2.22, 95% CI: 1.08, 4.56) and total problems (OR = 1.74, 95% CI: 1.13, 2.66), and low FT4 trajectory was associated with aggressive behavior (OR = 4.17, 95% CI: 1.22, 14.24). Conclusions Maternal thyroid hormone trajectories impact preschool boys’ behavioral development.

Association of Work-Family Conflict With Depression, Parenting Behaviors, and Socio-Behavioral Development of Children

This study investigated the associations of work-family conflict with the psychological well-being, parenting behaviors, and socio-emotional development of children aged between 2 and 6 (M = 4.14, SD = 1.30) and their working mothers. The sample was constructed with a random sampling method from Turkey, with nationally representative 700 working mothers. The age of the mothers ranged from 20 to 49 (M = 34.02, SD = 5.46). The data was based on maternal reports. The data was collected through the Organizational Support Scale, Work-Family Conflict Scale, Parenting Questionnaire, Temperament Scale, Eyberg Child Behavior Inventory, Adaptive Social Behavior Inventory, Child Behavior Checklist, Brief Symptoms Inventory, Multidimensional Scale of Perceived Social Support, and Work-Family Guilt Scale. The results of the study showed that (i) the mothers who reported higher levels of guilt due to working and lower levels of social support experienced higher levels of work-family conflict; (ii) the higher levels of work-family conflict increased the depression level and negative parenting behaviors in mothers while decreased the positive social-behavioral development in children, (iii) the social support had a buffering role in decreasing the negative effects of depression in mothers. This is the first study conducted with a nationally representative sample from Turkey to investigate an extensive ecology from mothers’ work-family conflict to their children’s socio-emotional development. The need for supporting policies to ameliorate working conditions and labor divisions for working mothers were emphasized by the study results. Keywords: Work-family conflict, parenting, support, socio-behavioral development

Schlaf‘, Kindlein, schlaf‘: Schlafverhalten von Säuglingen unter Propranolol-Therapie

Sleep problems are frequently reported in infants treated with propranolol for infantile hemangiomas, possibly serving as a marker for a negative impact on central nervous system function. In this cohort study, we objectively investigate the sleep behavior of infants with infantile hemangiomas on propranolol compared to a healthy, untreated control group. Sleep of propranolol-treated infants and controls was investigated using ankle actigraphy and a 24-h diary for 7–10 days at ages 3 and 6 months. The main outcome measures were the Number of Nighttime Awakenings and Sleep Efficiency. The main secondary outcome measures included 24-hour Total Sleep, daytime sleep behavior, and parent-rated infant sleep quality and behavioral development based on the Brief Infant Sleep Questionnaire (BISQ) and the age-appropriate Ages-and-Stages Questionnaire (ASQ), respectively. Fifty-four term-born infants were included in each cohort. No group difference in any investigated parameter was seen at age 3 months. At age 6 months, the propranolol group exhibited a decrease in Sleep Efficiency and a trend towards an increased Number of Nighttime Awakenings compared to the control group. Treated infants at 6 months also had shorter daytime waking periods. 24-hour Total Sleep was unaffected by propranolol. No negative impact of propranolol on subjective sleep quality and behavioral development was noted. <b>Conclusion:</b> Propranolol exerts a measurable yet mild impact on objectively assessed infants’ sleep measures. Behavioral developmental scores were unaffected. Our results support propranolol as first-line therapy for complicated infantile hemangiomas. <b>What is Known:</b> •Sleep disorders are frequently reported in infants with infantile hemangiomas treated with propranolol and often lead to treatment discontinuation. • Investigations of the sleep pattern in this patient group using objective measures are lacking. <b>What is New:</b> • The sleep pattern of propranolol-treated infants is assessed using actigraphy and a 24-h sleep diary and compared to healthy, untreated controls. • Propranolol leads to a decreased sleep efficiency at night and an increased demand of daytime sleep, yet effects are mild overall.

Maternal stress effects on infant development in wild Verreaux's sifaka (Propithecus verreauxi)

Maternal effects mediated by nutrients or specific endocrine states of the mother can affect infant development. Specifically, pre- and postnatal maternal stress associated with elevated glucocorticoid (GC) output is known to influence the phenotype of the offspring, including their physical and behavioral development. These developmental processes, however, remain relatively poorly studied in wild vertebrates, including primates with their relatively slow life histories. Here, we investigated the effects of maternal stress, assessed by fecal glucocorticoid output, on infant development in wild Verreaux’s sifakas (Propithecus verreauxi), a group-living Malagasy primate. In a first step, we investigated factors predicting maternal fecal glucocorticoid metabolite (fGCM) concentrations, how they impact infants’ physical and behavioral development during the first 6 months of postnatal life as well as early survival during the first 1.5 years of postnatal life. We collected fecal samples of mothers for hormone assays and behavioral data of 12 infants from two birth cohorts, for which we also assessed growth rates. Maternal fGCM concentrations were higher during the late prenatal but lower during the postnatal period compared to the early/mid prenatal period and were higher during periods of low rainfall. Infants of mothers with higher prenatal fGCM concentrations exhibited faster growth rates and were more explorative in terms of independent foraging and play. Infants of mothers with high pre- and postnatal fGCM concentrations were carried less and spent more time in nipple contact. Time mothers spent carrying infants predicted infant survival: infants that were more carried had lower survival, suggesting that they were likely in poorer condition and had to be cared for longer. Thus, the physical and behavioral development of these young primates were impacted by variation in maternal fGCM concentrations during the first 6 months of their lives, presumably as an adaptive response to living in a highly seasonal, but unpredictable environment. Significance statement The early development of infants can be impacted by variation in maternal condition. These maternal effects can be mediated by maternal stress (glucocorticoid hormones) and are known to have downstream consequences for behavior, physiology, survival, and reproductive success well into adulthood. However, the direction of the effects of maternal physiological GC output on offspring development is highly variable, even within the same species. We contribute comparative data on maternal stress effects on infant development in a Critically Endangered primate from Madagascar. We describe variation in maternal glucocorticoid output as a function of ecological and reproductive factors and show that patterns of infant growth, behavioral development, and early survival are predicted by maternal glucocorticoids. Our study demonstrates how mothers can influence offspring fitness in response to challenging environmental conditions.