Chapter 11. Trastuzumab Deruxtecan Targeting HER2-expressing Cancers with a DXd-ADC System Consisting of a Novel Protease-sensitive Linker and DNA Topoisomerase I Inhibitor with a Hydroxyl Group

2021 ◽  
pp. 422-450
Author(s):  
Takashi Nakada ◽  
Yuki Abe ◽  
Toshinori Agatsuma
Keyword(s):  
Topoisomerase I ◽  
Hydroxyl Group ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor

scholarly journals beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin.

1993 ◽  
Vol 268 (30) ◽  
pp. 22463-22468 ◽  
Author(s):  
C.J. Li ◽  
L Averboukh ◽  
A.B. Pardee
Keyword(s):  
Mode Of Action ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor

Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit

Xenobiotica ◽  
2009 ◽  
Vol 39 (3) ◽  
pp. 273-281 ◽  
Author(s):  
S. X. Zhang ◽  
P. W. Yang ◽  
D. C. Zhang ◽  
W. Q. Dong ◽  
F. H. Zhang ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

2003 ◽  
Vol 66 (10) ◽  
pp. 1981-1991 ◽  
Author(s):  
Chun-Yuan Ting ◽  
Chia-Tse Hsu ◽  
Hsiang-Ting Hsu ◽  
Jin-Shan Su ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Human Dna ◽  
Human Dna Topoisomerase I

scholarly journals Development of novel DNA topoisomerase I inhibitor based ADC technology

2019 ◽  
Vol 34 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Yuki Abe ◽  
Takashi Nakada ◽  
Toshinori Agatsuma
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor

Activity of crude extract ofRubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomerase I inhibitor

2000 ◽  
Vol 23 (4) ◽  
pp. 338-343 ◽  
Author(s):  
Ji Hyeon Lee ◽  
Yoon-Ah Ham ◽  
Sang-Ho Choi ◽  
Eun Ok Im ◽  
Jee H. Jung ◽  
...  
Keyword(s):  
Crude Extract ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Apoptosis Inducer

DNA Topoisomerase I Inhibitor, Ergosterol Peroxide fromPenicillium oxalicum

Planta Medica ◽  
2005 ◽  
Vol 71 (1) ◽  
pp. 77-79 ◽  
Author(s):  
Li-Ming Yang Kuo ◽  
Kuei-Yuh Chen ◽  
Shy-Yuan Hwang ◽  
Jin-Liang Chen ◽  
Yen-Yin Liu ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Ergosterol Peroxide

Formulation of injectable glycyrrhizic acid-hydroxycamptothecin micelles as new generation of DNA topoisomerase I inhibitor for enhanced antitumor activity

2019 ◽  
Vol 571 ◽  
pp. 118693 ◽  
Author(s):  
Jieying Cai ◽  
Shiwen Luo ◽  
Xueli Lv ◽  
Yingguang Deng ◽  
Hongyuan Huang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Topoisomerase I ◽  
Glycyrrhizic Acid ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
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