Synthesis and optimization of tri(propylene glycol) glycerolate diacrylate cross-linked polystyrene resin in polypeptide synthesis: role of the macromolecular support in solid phase peptide synthesis

2002 ◽  
pp. 2886-2895 ◽  
Author(s):  
P. G. Sasikumar ◽  
K. S. Kumar ◽  
C. Arunan ◽  
V. N. Rajasekharan Pillai
Keyword(s):  
Propylene Glycol ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polypeptide Synthesis ◽  
Polystyrene Resin

scholarly journals Role of capping in peptide synthesis

2020 ◽  
Vol 11 (4) ◽  
pp. 5225-5228
Author(s):  
Deepshikha Verma ◽  
Pillai V N R ◽  
Giriraj Tailor
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Protecting Groups ◽  
Amino Groups ◽  
Peptide Chemistry ◽  
Fmoc Spps ◽  
Reliable Methods ◽  
Important Test

Protecting groups like Fmoc and coupling both steps are essential to monitoring the Fmoc SPPS (Solid Phase Peptide Synthesis) reaction completion. Reliable methods are used to detect the unreacted number of amino groups for monitoring these two essential reaction steps of coupling and cleavage. The ability to detect the complete coupling, incomplete coupling or failure of coupling we use many colour tests in the laboratory and based on this the Fmoc peptide chemistry allows the control of the completion of the Fmoc cleavage. The most important test used is the Kaiser test and highly recommended to monitor the coupling and cleavage steps. If the result of colour tests is positive after coupling, then the second coupling should be performed. Then again use the colour test to detect the level of coupling. If the result is still slightly positive, repeat coupling with the smaller modification of reagents such as used PyBOP instead of HOBT AND HOAT. These colour tests help in revealing the presence of unreacted amino-functional groups. Thus, we need to block these free N-terminal of amino- acids which help in avoiding the making of deletion of sequence.

Benzyloxy Derivatives of Triazine-based Coupling Reagents Designed for an Efficient Solid Phase Peptide Synthesis on Polystyrene Resin

2007 ◽  
Vol 13 (1-2) ◽  
pp. 229-236 ◽  
Author(s):  
Konrad Jastrząbek ◽  
Beata Kolesińska ◽  
Giuseppina Sabatino ◽  
Fabio Rizzolo ◽  
Anna M. Papini ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Coupling Reagents ◽  
Polystyrene Resin ◽  
Derivatives Of

Ionic liquid incorporated polystyrene resin for solid-phase peptide synthesis

2011 ◽  
Vol 52 (13) ◽  
pp. 1459-1461 ◽  
Author(s):  
Hong-Jun Cho ◽  
Sang-Myung Lee ◽  
Sungwon Jung ◽  
Tae-Kyung Lee ◽  
Hyo-Jin Yoon ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polystyrene Resin

Preparation of poly (ethylene glycol) acrylate grafted polystyrene resin for solid-phase peptide synthesis

2012 ◽  
Vol 72 (10) ◽  
pp. 773-780 ◽  
Author(s):  
Rongyue Zhang ◽  
Qiang Li ◽  
Jing Zhang ◽  
Juan Li ◽  
Guanghui Ma ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Poly Ethylene Glycol ◽  
Polystyrene Resin ◽  
Poly Ethylene
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