The role of polymer support crosslinking on reaction rates for solid-phase peptide synthesis

1989 ◽  
Vol 44 (11) ◽  
pp. 2760-2762 ◽  
Author(s):  
Wen-Yih Chen ◽  
Gary L. Foutch
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Reaction Rates ◽  
Polymer Support

scholarly journals Role of capping in peptide synthesis

2020 ◽  
Vol 11 (4) ◽  
pp. 5225-5228
Author(s):  
Deepshikha Verma ◽  
Pillai V N R ◽  
Giriraj Tailor
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Protecting Groups ◽  
Amino Groups ◽  
Peptide Chemistry ◽  
Fmoc Spps ◽  
Reliable Methods ◽  
Important Test

Protecting groups like Fmoc and coupling both steps are essential to monitoring the Fmoc SPPS (Solid Phase Peptide Synthesis) reaction completion. Reliable methods are used to detect the unreacted number of amino groups for monitoring these two essential reaction steps of coupling and cleavage. The ability to detect the complete coupling, incomplete coupling or failure of coupling we use many colour tests in the laboratory and based on this the Fmoc peptide chemistry allows the control of the completion of the Fmoc cleavage. The most important test used is the Kaiser test and highly recommended to monitor the coupling and cleavage steps. If the result of colour tests is positive after coupling, then the second coupling should be performed. Then again use the colour test to detect the level of coupling. If the result is still slightly positive, repeat coupling with the smaller modification of reagents such as used PyBOP instead of HOBT AND HOAT. These colour tests help in revealing the presence of unreacted amino-functional groups. Thus, we need to block these free N-terminal of amino- acids which help in avoiding the making of deletion of sequence.

A novel core-shell type polymer support for solid-phase peptide synthesis

2000 ◽  
Vol 41 (39) ◽  
pp. 7481-7485 ◽  
Author(s):  
Jin Ku Cho ◽  
Byeong-Deog Park ◽  
Yoon-Sik Lee
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support ◽  
Core Shell ◽  
Shell Type

scholarly journals Bromoacylpolystyrene, a New Type of Polymer Support for Solid Phase Peptide Synthesis

1969 ◽  
Vol 17 (2) ◽  
pp. 411-412 ◽  
Author(s):  
TOMISHIGE MIZOGUCHI ◽  
KEISUKE SHIGEZANE ◽  
NORIO TAKAMURA
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support ◽  
New Type

SUBPOL:  A Novel Sucrose-Based Polymer Support for Solid-Phase Peptide Synthesis and Affinity Chromatography Applications

2003 ◽  
Vol 125 (44) ◽  
pp. 13415-13426 ◽  
Author(s):  
Alexander Poschalko ◽  
Thomas Rohr ◽  
Heinrich Gruber ◽  
Alberto Bianco ◽  
Gilles Guichard ◽  
...  
Keyword(s):  
Affinity Chromatography ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support

scholarly journals Solid Phase Peptide Synthesis employing Haloacylpolystyrene as a Polymer Support

1970 ◽  
Vol 18 (7) ◽  
pp. 1465-1474 ◽  
Author(s):  
TOMISHIGE MIZOGUCHI ◽  
KEISUKE SHIGEZANE ◽  
NORIO TAKAMURA
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support

scholarly journals Solid Phase Peptide Synthesis by Four Component Condensation: Peptide Formation on an Isocyano Polymer Support

1981 ◽  
Vol 36 (9) ◽  
pp. 1202-1203 ◽  
Author(s):  
Reza Arshady ◽  
Ivar Ugi
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Trifluoroacetic Acid ◽  
Room Temperature ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support ◽  
Small Peptides ◽  
Peptide Formation

Abstract Coupling of various protected amino acids or small peptides on an isocyano polymer and in the presence of 1 -methyl-3-formylindole demonstrates the feasibility of peptide formation by four component condensation on a polymer support, and the final peptide is detached from the resin by 50% trifluoroacetic acid in aceto-nitrile at room temperature.

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