Facile axial chirality control by using a precursor with central chirality. Application to the preparation of new axially chiral diphosphine complexes for asymmetric catalysis

2002 ◽  
pp. 2546-2547 ◽  
Author(s):  
Matthias Lotz ◽  
Gernot Kramer ◽  
Paul Knochel
Keyword(s):  
Asymmetric Catalysis ◽  
Axial Chirality ◽  
Axially Chiral ◽  
Chirality Control

Axial Chirality Control of Gold(biphep) Complexes by Chiral Anions: Application to Asymmetric Catalysis

2009 ◽  
Vol 121 (33) ◽  
pp. 6189-6193 ◽  
Author(s):  
Kohsuke Aikawa ◽  
Masafumi Kojima ◽  
Koichi Mikami
Keyword(s):  
Asymmetric Catalysis ◽  
Axial Chirality ◽  
Chirality Control

scholarly journals Recent advances in the asymmetric phosphoric acid-catalyzed synthesis of axially chiral compounds

2021 ◽  
Vol 17 ◽  
pp. 2729-2764
Author(s):  
Alemayehu Gashaw Woldegiorgis ◽  
Xufeng Lin
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Medicinal Chemistry ◽  
High Efficiency ◽  
Biologically Active ◽  
Chiral Compounds ◽  
Chiral Phosphoric Acid ◽  
Wide Range ◽  
Axially Chiral ◽  
Acid Catalyzed

In recent years, the synthesis of axially chiral compounds has received considerable attention due to their extensive application as biologically active compounds in medicinal chemistry and as chiral ligands in asymmetric catalysis. Chiral phosphoric acids are recognized as efficient organocatalysts for a variety of enantioselective transformations. In this review, we summarize the recent development of chiral phosphoric acid-catalyzed synthesis of a wide range of axially chiral biaryls, heterobiaryls, vinylarenes, N-arylamines, spiranes, and allenes with high efficiency and excellent stereoselectivity.

Organocatalytic Asymmetric Methodologies towards the Synthesis of Atropisomeric N-Heterocycles

Synthesis ◽  
2020 ◽  
Vol 52 (17) ◽  
pp. 2450-2468
Author(s):  
Vasco Corti ◽  
Giulio Bertuzzi
Keyword(s):  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Chirality Transfer ◽  
Axial Chirality ◽  
Axially Chiral ◽  
Molecular Architectures

A perspective on the literature dealing with the organocatalytic asymmetric preparation of axially chiral N-heterocycles is provided. A particular focus is devoted to rationalize the synthetic strategies employed in each case. Moreover, specific classes of organocatalysts are shown to stand out as privileged motives for the stereoselective preparation of such synthetically challenging molecular architectures. Finally, an overview of the main trends in the field is given.1 Introduction2 Five-Membered Rings2.1 Arylation2.2 Dynamic Kinetic Resolution2.3 Ring Construction2.4 Central-to-Axial Chirality Conversion and Chirality Transfer2.5 Desymmetrization3 Six-Membered Rings3.1 Desymmetrization3.2 (Dynamic) Kinetic Resolution3.3 Ring Construction3.4 Central-to-Axial Chirality Conversion4 Conclusion

scholarly journals Conversion of two stereocenters to one or two chiral axes: atroposelective synthesis of 2,3-diarylbenzoindoles

2019 ◽  
Vol 10 (28) ◽  
pp. 6777-6784 ◽  
Author(s):  
Yu-Long Hu ◽  
Zhe Wang ◽  
Hui Yang ◽  
Jie Chen ◽  
Zi-Bo Wu ◽  
...  
Keyword(s):  
Axial Chirality ◽  
Chiral Compounds ◽  
Efficient Access ◽  
Axially Chiral

Central-to-axial chirality conversion provides efficient access to axially chiral compounds, and several examples regarding the conversion of one, two or four stereocenters to one axis have been reported.

ChemInform Abstract: Axial Chirality Control During Suzuki-Miyaura Cross-Coupling Reactions: The tert-Butylsulfinyl Group as an Efficient Chiral Auxiliary.

ChemInform ◽  
2010 ◽  
Vol 41 (13) ◽  
Author(s):  
Francoise Colobert ◽  
Victoria Valdivia ◽  
Sabine Choppin ◽  
Frederic R. Leroux ◽  
Inmaculada Fernandez ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Chiral Auxiliary ◽  
Coupling Reactions ◽  
Axial Chirality ◽  
Cross Coupling Reactions ◽  
Chirality Control
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