Efficient asymmetric hydrogenation of quinolines in neat water catalyzed by chiral cationic Ru-diamine complexes

2014 ◽  
Vol 4 (9) ◽  
pp. 2887-2890 ◽  
Author(s):  
Zhusheng Yang ◽  
Fei Chen ◽  
Yan-Mei He ◽  
Nianfa Yang ◽  
Qing-Hua Fan
Keyword(s):  
Asymmetric Hydrogenation ◽  
Enantioselective Hydrogenation ◽  
Neat Water ◽  
Highly Effective

The first highly effective and enantioselective hydrogenation of quinolines catalyzed by chiral cationic Ru-diamine complexes in undegassed water was developed.

Synthesis of polymers containing chiral 1,2-diamine derivatives and their application to asymmetric reactions

2007 ◽  
Vol 79 (9) ◽  
pp. 1471-1479 ◽  
Author(s):  
Shinichi Itsuno ◽  
Miyuki Takahashi ◽  
Yukihiro Arakawa ◽  
Naoki Haraguchi
Keyword(s):  
Asymmetric Hydrogenation ◽  
Enantioselective Hydrogenation ◽  
Transfer Hydrogenation ◽  
Hydrogenation Catalyst ◽  
Polymer Support ◽  
Secondary Alcohols ◽  
Aromatic Ketones ◽  
Neat Water ◽  
Polymeric Catalyst ◽  
High Level

Polymer-supported chiral 1,2-diamine derivatives have been prepared. The polymers containing free 1,2-diamine moiety were applied to enantioselective hydrogenation catalyst by combination with RuCl2-BINAP complex. Asymmetric hydrogenation of aromatic ketones was performed by means of the polymeric catalyst derived from these polymers to give the chiral secondary alcohols with high ee in quantitative conversion. The polymers containing 1,2-diamine monosulfonamide were applied to enantioselective transfer hydrogenation catalyst by combination with RuCl2-p-cymene complex. Asymmetric transfer hydrogenation of aromatic ketones was performed by means of the polymeric catalyst to afford the chiral secondary alcohols. A high level of enantioselectivities up to 99 % ee was attained in neat water by using the polymeric catalyst prepared from quaternary ammonium salt-type polymer support.

N-Methylephedrium Salts as Chiral Surfactants for Asymmetric Hydrogenation in Neat Water with Rhodium(0) Nanocatalysts

ChemSusChem ◽  
2010 ◽  
Vol 3 (11) ◽  
pp. 1276-1279 ◽  
Author(s):  
Elodie Guyonnet Bilé ◽  
Audrey Denicourt-Nowicki ◽  
Rita Sassine ◽  
Patricia Beaunier ◽  
Franck Launay ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Neat Water ◽  
Chiral Surfactants

Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand

Synlett ◽  
2020 ◽  
Vol 31 (03) ◽  
pp. 285-289 ◽  
Author(s):  
Fei Ling ◽  
Jiachen Chen ◽  
Sanfei Nian ◽  
Huacui Hou ◽  
Xiao Yi ◽  
...  
Keyword(s):  
Functional Group ◽  
Asymmetric Hydrogenation ◽  
Enantioselective Hydrogenation ◽  
Tridentate Ligand ◽  
Easy Access ◽  
Tridentate Ligands

A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable ‘side arm’ groups have been established, enabling the inexpensive base-promoted asymmetric hydrogenation of simple ketones with outstanding activities (up to 8200 TON) and good enantioselectivities (up to 88.5% ee). This protocol features wide substrate scope and functional group tolerance, thereby providing easy access to a key intermediate of crizotinib.

Enantioselective hydrogenation of N-heteroaromatics catalyzed by chiral diphosphine modified binaphthyl palladium nanoparticles

2017 ◽  
Vol 7 (23) ◽  
pp. 5515-5520 ◽  
Author(s):  
Yun-Tao Xia ◽  
Jing Ma ◽  
Xiao-Dong Wang ◽  
Lei Yang ◽  
Lei Wu
Keyword(s):  
Palladium Nanoparticles ◽  
Asymmetric Hydrogenation ◽  
Enantioselective Hydrogenation

The first application of binaphthyl-stabilized palladium nanoparticles (Bin-PdNPs) with chiral modifiers in asymmetric hydrogenation of N-heteroaromatics is revealed.

ChemInform Abstract: Highly Effective and Recyclable Dendritic BINAP Ligands for Asymmetric Hydrogenation.

ChemInform ◽  
2010 ◽  
Vol 31 (33) ◽  
pp. no-no
Author(s):  
Qing-Hua Fan ◽  
Yong-Ming Chen ◽  
Xiao-Min Chen ◽  
Da-Zhi Jiang ◽  
Fu Xi ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Highly Effective

Rhodium/bisphosphine-thiourea-catalyzed enantioselective hydrogenation of α,β-unsaturated N-acylpyrazoles

2016 ◽  
Vol 52 (78) ◽  
pp. 11677-11680 ◽  
Author(s):  
Pan Li ◽  
Xinquan Hu ◽  
Xiu-Qin Dong ◽  
Xumu Zhang
Keyword(s):  
Catalytic System ◽  
Asymmetric Hydrogenation ◽  
Enantioselective Hydrogenation ◽  
High Yields

We successfully extended our Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system to asymmetric hydrogenation of α,β-unsaturated N-acylpyrazoles affording products with high yields and excellent enantioselectivities (up to 97% yield, 99% ee).

ChemInform Abstract: A Highly Effective Rhodium Spirocyclic Phosphinite Catalyst for the Asymmetric Hydrogenation of Enamides.

ChemInform ◽  
2010 ◽  
Vol 30 (21) ◽  
pp. no-no
Author(s):  
Wenhao Hu ◽  
Ming Yan ◽  
Chak-Po Lau ◽  
S. M. Yang ◽  
Albert S. C. Chan ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Highly Effective

scholarly journals Synthesis and Structural Characterization of a Highly Effective Chiral Dipyridylphosphine Ligand and Its Application in the Ru-Catalyzed Asymmetric Hydrogenation of β-Ketoesters

Synlett ◽  
2001 ◽  
Vol 2001 (Special Issue) ◽  
pp. 1050-1054 ◽  
Author(s):  
Jing Wu ◽  
Hua Chen ◽  
Zhong-Yuan Zhou ◽  
Chi Hung Yeung ◽  
Albert S. C. Chan
Keyword(s):  
Structural Characterization ◽  
Asymmetric Hydrogenation ◽  
Highly Effective
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