Synthesis and biological evaluation of (−)-kainic acid analogues as phospholipase D-coupled metabotropic glutamate receptor ligands

2014 ◽  
Vol 12 (47) ◽  
pp. 9638-9643 ◽  
Author(s):  
Chiara Zanato ◽  
Sonia Watson ◽  
Guy S. Bewick ◽  
William T. A. Harrison ◽  
Matteo Zanda
Keyword(s):  
Kainic Acid ◽  
Glutamate Receptor ◽  
Phospholipase D ◽  
Metabotropic Glutamate Receptor ◽  
Muscle Spindles ◽  
Biological Evaluation ◽  
Receptor Ligands ◽  
Mglu Receptor ◽  
Metabotropic Glutamate ◽  
Synthesis And Biological Evaluation

A “click” 4-(1,2,3-triazolyl)-kainate derivative and its biotinylated version potently increase stretch-induced afferent firing in muscle spindles, probably acting through a hitherto uncloned phospholipase D (PLD)-coupled mGlu receptor.

Synthesis and Preliminary Biological Evaluation of 2′-Substituted 2-(3′-Carboxybicyclo[1.1.1]pentyl)glycine Derivatives as Group I Selective Metabotropic Glutamate Receptor Ligands

ChemMedChem ◽  
2006 ◽  
Vol 1 (3) ◽  
pp. 358-365 ◽  
Author(s):  
Roberto Pellicciari ◽  
Rosanna Filosa ◽  
Maria Carmela Fulco ◽  
Maura Marinozzi ◽  
Antonio Macchiarulo ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Biological Evaluation ◽  
Receptor Ligands ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Glycine Derivatives

New perspectives for the development of selective metabotropic glutamate receptor ligands

1999 ◽  
Vol 375 (1-3) ◽  
pp. 277-294 ◽  
Author(s):  
Jean-Philippe Pin ◽  
Cyril De Colle ◽  
Anne-Sophie Bessis ◽  
Francine Acher
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Ligands ◽  
Metabotropic Glutamate
Sign in / Sign up

Export Citation Format

Share Document