Novel amino-cyclodextrin cross-linked oligomer as efficient carrier for anionic drugs: a spectroscopic and nanocalorimetric investigation

The amino groups of a novel oligomer of amino-cyclodextrins play a relevant role in the recognition process of diclofenac and this highlights the potential of short polymeric chains as new drug carriers.

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Poly(d,llactide–co-ethyl ethylene phosphate)s as new drug carriers

Journal of Controlled Release ◽

10.1016/s0168-3659(03)00294-3 ◽

2003 ◽

Vol 92 (1-2) ◽

pp. 39-48 ◽

Cited By ~ 71

Author(s):

Jie Wen ◽

Gloria J.A Kim ◽

Kam W Leong

Keyword(s):

Drug Carriers ◽

New Drug

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Efficient modification of PAMAM G1 dendrimer surface with β-cyclodextrin units by CuAAC: impact on the water solubility and cytotoxicity

RSC Advances ◽

10.1039/d0ra02574g ◽

2020 ◽

Vol 10 (43) ◽

pp. 25557-25566

Author(s):

Kendra Sorroza-Martínez ◽

Israel González-Méndez ◽

Ricardo D. Martínez-Serrano ◽

José D. Solano ◽

Andrea Ruiu ◽

...

Keyword(s):

Water Solubility ◽

Drug Carriers ◽

Clinical Applications ◽

Amino Groups

The toxicity of the poly(amidoamine) dendrimers (PAMAM) caused by the peripheral amino groups has been a limitation for their use as drug carriers in clinical applications.

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Amphiphilic Polymer Nanoparticles: Characterization and Assessment as New Drug Carriers

Macromolecular Bioscience ◽

10.1002/mabi.200900135 ◽

2009 ◽

Vol 9 (11) ◽

pp. 1116-1126 ◽

Cited By ~ 10

Author(s):

Pranabesh Dutta ◽

Saurabh Shrivastava ◽

Joykrishna Dey

Keyword(s):

Drug Carriers ◽

Amphiphilic Polymer ◽

Polymer Nanoparticles ◽

New Drug ◽

Nanoparticles Characterization

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Polymeric micelles as new drug carriers

Advanced Drug Delivery Reviews ◽

10.1016/s0169-409x(96)00401-2 ◽

1996 ◽

Vol 21 (2) ◽

pp. 107-116 ◽

Cited By ~ 490

Author(s):

Glen S. Kwon ◽

Teruo Okano

Keyword(s):

Polymeric Micelles ◽

Drug Carriers ◽

New Drug

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Synthesis and surface modification of chitosan built nanohydrogel with antiviral and antimicrobial agent for controlled drug delivery

Biointerface Research in Applied Chemistry ◽

10.33263/briac96.439445 ◽

2019 ◽

Vol 9 (6) ◽

pp. 4439-4445 ◽

Cited By ~ 5

Keyword(s):

Drug Administration ◽

Drug Loading ◽

Internal Surface ◽

Drug Carriers ◽

Crosslinking Density ◽

Bromocresol Green ◽

Internal Surface Area ◽

Physiological Conditions ◽

Model Drug ◽

Anionic Drugs

As hydrophobic drug carriers, chitosan (CS) and Starch (SR) were copolymerized as biodegradable nanohydrogel and were functionalized with pthalic-anhydride and hexamethylenetetramine via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide catalyzed coupling, respectively. The structure, morphology, physicochemical and drug loading performance of native and functioned hydrogel were investigated by using several characterization techniques. With the successive functionalization the significant properties like porosity increases and crosslinking density decreases due to the formation of hydrophilic contacts with aqueous solutions. The FESEM analysis revealed the hydrogel matrices with uniform particle size, porosity and deep pores with high internal surface area for extreme swelling and interacting with the drug and biomolecules for efficient drug administration. The effect of induced functionalities on the physicochemical performance and release of hydrophobic- anionic model drug (Bromocresol green) were studied at physiological conditions. The drug release capability of the synthesized nanohydrogel was increased from 65% to 80% and 85% by successive functionalization. The drug administration in selective hydrogel was not significant, presumably due to stronger H-bonding and entanglement within the system which was finely tuned by the induced hydrophilic, flexible and biocompatible functionalities in term of extended interfaces for the drug solutions. The physicochemical and electrokinetic performances suggested the selective hydrogel as promising carriers for the hydrophobic- anionic drugs at physiological conditions.

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Synthesis of New Drug Carriers of Metronidazoleas Antifungal Agents

Medico-Legal Update ◽

10.37506/mlu.v20i4.1951 ◽

2020 ◽

Vol 20 (4) ◽

Keyword(s):

Antifungal Agents ◽

Drug Carriers ◽

New Drug

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Porous Metal–Organic Frameworks as New Drug Carriers

Comprehensive Biomaterials ◽

10.1016/b978-0-08-055294-1.00143-4 ◽

2011 ◽

pp. 559-573 ◽

Cited By ~ 2

Author(s):

P. Horcajada ◽

C. Serre ◽

R. Gref ◽

P. Couvreur

Keyword(s):

Metal Organic Frameworks ◽

Porous Metal ◽

Drug Carriers ◽

New Drug ◽

Metal Organic

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Aldehyde gold clusters for molecular labeling

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010014066x ◽

1995 ◽

Vol 53 ◽

pp. 858-859

Author(s):

James F. Hainfeld ◽

Frederic R. Furuya

Keyword(s):

Covalent Bond ◽

Aldehyde Group ◽

Gold Clusters ◽

Side Reactions ◽

Amino Groups ◽

Sodium Cyanoborohydride ◽

Schiff’S Base ◽

Protein Molecules ◽

Hydroxysuccinimide Esters ◽

Primary Amino

Glutaraldehyde is a useful tissue and molecular fixing reagents. The aldehyde moiety reacts mainly with primary amino groups to form a Schiff's base, which is reversible but reasonably stable at pH 7; a stable covalent bond may be formed by reduction with, e.g., sodium cyanoborohydride (Fig. 1). The bifunctional glutaraldehyde, (CHO-(CH2)3-CHO), successfully stabilizes protein molecules due to generally plentiful amines on their surface; bovine serum albumin has 60; 59 lysines + 1 α-amino. With some enzymes, catalytic activity after fixing is preserved; with respect to antigens, glutaraldehyde treatment can compromise their recognition by antibodies in some cases. Complicating the chemistry somewhat are the reported side reactions, where glutaraldehyde reacts with other amino acid side chains, cysteine, histidine, and tyrosine. It has also been reported that glutaraldehyde can polymerize in aqueous solution. Newer crosslinkers have been found that are more specific for the amino group, such as the N-hydroxysuccinimide esters, and are commonly preferred for forming conjugates. However, most of these linkers hydrolyze in solution, so that the activity is lost over several hours, whereas the aldehyde group is stable in solution, and may have an advantage of overall efficiency.

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