The design of a spiro-pyrrolidine organocatalyst and its application to catalytic asymmetric Michael addition for the construction of all-carbon quaternary centers

2015 ◽  
Vol 51 (49) ◽  
pp. 9979-9982 ◽  
Author(s):  
Jin-Miao Tian ◽  
Yong-Hai Yuan ◽  
Yong-Qiang Tu ◽  
Fu-Min Zhang ◽  
Xiao-Bo Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Silyl Ether ◽  
Michael Addition Reaction ◽  
Quaternary Centers ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

A novel chiral spiro-pyrrolidine silyl ether organocatalyst has been designed and applied to an asymmetric Michael addition reaction.

Synthesis of Chiral Tertiary Amine–Thioureas Based on Spirobi­indane and Application in Catalytic Asymmetric Michael Addition Reaction

Synthesis ◽  
2020 ◽  
Vol 52 (07) ◽  
pp. 1131-1139
Author(s):  
Zhao Han ◽  
Xufeng Lin
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

A series of novel chiral bifunctional tertiary amine–thioureas based on spirobiindane were designed and synthesized as organo­catalysts. One of these catalysts was shown to promote the asymmetric Michael addition reaction of 1,3-diphenylpropane-1,3-dione to nitro­olefins, affording the desired products in good yields (up to 95%) and enantioselectivities (up to 98% ee).

Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts

2014 ◽  
Vol 12 (40) ◽  
pp. 8008-8018 ◽  
Author(s):  
Ahmed Kamal ◽  
Manda Sathish ◽  
Vunnam Srinivasulu ◽  
Jadala Chetna ◽  
Kunta Chandra Shekar ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Mechanistic Studies ◽  
Michael Addition Reaction ◽  
Asymmetric Michael Addition

New pyrrolidinyl-oxazole-carboxamides were synthesized and utilized as efficient organocatalysts for asymmetric Michael addition reaction. In addition, computational mechanistic studies were performed.

Sign in / Sign up

Export Citation Format

Share Document