Combination assay of lung cancer associated serum markers using surface-enhanced Raman spectroscopy

2016 ◽  
Vol 4 (10) ◽  
pp. 1811-1817 ◽  
Author(s):  
Chunyuan Song ◽  
Yanjun Yang ◽  
Boyue Yang ◽  
Linghua Min ◽  
Lianhui Wang
Keyword(s):  
Lung Cancer ◽  
Raman Spectroscopy ◽  
Human Serum ◽  
Surface Enhanced Raman Spectroscopy ◽  
Serum Markers ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

A highly sensitive and specific SERS-based combination assay of lung cancer associated serum markers is reported, and the LODs of CEA and NSE in human serum specimens are 1.48 pg mL−1 and 2.04 pg mL−1, respectively.

Combining vancomycin-modified gold nanorod arrays and colloidal nanoparticles as the sandwich model for discrimination of gram-positive bacteria and their detection via surface-enhanced Raman spectroscopy (SERS)

The Analyst ◽  
2021 ◽  
Author(s):  
Araz Norouz Dizaji ◽  
Nihal Simsek Ozek ◽  
Ferhunde Aysin ◽  
Ayfer Calis ◽  
Asli Yilmaz ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Colloidal Nanoparticles ◽  
Nanorod Arrays ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Sensor Platform ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

This study reports the development of a highly sensitive antibiotic-based discrimination and sensor platform for the detection of gram-positive bacteria through surface-enhanced Raman spectroscopy (SERS). Herein, the combination of gold...

scholarly journals Label-Free Detection of Human Serum Using Surface-Enhanced Raman Spectroscopy Based on Highly Branched Gold Nanoparticle Substrates for Discrimination of Non-Small Cell Lung Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Xiaowei Cao ◽  
Zhenyu Wang ◽  
Liyan Bi ◽  
Jie Zheng
Keyword(s):  
Lung Cancer ◽  
Raman Spectroscopy ◽  
Cell Lung Cancer ◽  
Surface Enhanced Raman Spectroscopy ◽  
Small Cell ◽  
Label Free ◽  
Small Cell Lung ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman

Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on serum in screening tests. In this study, a potential label-free serum test based on SERS spectroscopy was developed to analyze human serum for the diagnosis of the non-small cell lung cancer (NSCLC). We firstly synthesized novel highly branched gold nanoparticles (HGNPs) at high yield through a one-step reduction of HAuCl4 with dopamine hydrochloride at 60°C. Then, HGNP substrates with good reproducibility, uniformity, and high SERS effect were fabricated by the electrostatically assisted (3-aminopropyl) triethoxysilane-(APTES-) functionalized silicon wafer surface-sedimentary self-assembly method. Using as-prepared HGNP substrates as a high-performance sensing platform, SERS spectral data of serum obtained from healthy subjects, lung adenocarcinoma patients, lung squamous carcinoma patients, and large cell lung cancer patients were collected. The difference spectra among different types of NSCLC were compared, and analysis result revealed their intrinsic difference in types and contents of nucleic acids, proteins, carbohydrates, amino acids, and lipids. SERS spectra were analyzed by principal component analysis (PCA), which was able to distinguish different types of NSCLC. Considering its time efficiency, being label-free, and sensitivity, SERS based on HGNP substrates is very promising for mass screening NSCLC and plays an important role in the detection and prevention of other diseases.

Silver-coated Si nanograss as highly sensitive surface-enhanced Raman spectroscopy substrates

2009 ◽  
Vol 96 (4) ◽  
pp. 793-797 ◽  
Author(s):  
Jing Tang ◽  
Fung Suong Ou ◽  
Huei Pei Kuo ◽  
Min Hu ◽  
William F. Stickle ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Self-assembly of ultrathin gold nanowires and single walled carbon nanotubes as a highly sensitive substrate for surface enhanced Raman spectroscopy

2016 ◽  
Vol 40 (9) ◽  
pp. 7286-7289 ◽  
Author(s):  
Yuanchao Zhang ◽  
Jingquan Liu ◽  
Da Li ◽  
Fuhua Yan ◽  
Xin Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Raman Spectroscopy ◽  
Self Assembly ◽  
Single Walled Carbon Nanotubes ◽  
Surface Enhanced Raman Spectroscopy ◽  
Gold Nanowires ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Walled Carbon Nanotubes

Self-assembly of ultrathin gold nanowires and single-walled carbon nanotubes as highly sensitive substrates for surface enhanced Raman spectroscopy.

Rhodium nanocubes and nanotripods for highly sensitive ultraviolet surface-enhanced Raman spectroscopy

The Analyst ◽  
2018 ◽  
Vol 143 (10) ◽  
pp. 2310-2322 ◽  
Author(s):  
Rupali Das ◽  
R. K. Soni
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Excitation Wavelength ◽  
Rhodium Nanoparticles ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
532 Nm

DUV-UV (266 nm), UV (325 nm) and visible (532 nm) excitation-wavelength-dependent SERS investigation of adenine molecules on rhodium nanoparticles.

scholarly journals Boron nitride nanosheets as improved and reusable substrates for gold nanoparticles enabled surface enhanced Raman spectroscopy

2015 ◽  
Vol 17 (12) ◽  
pp. 7761-7766 ◽  
Author(s):  
Qiran Cai ◽  
Lu Hua Li ◽  
Yuanlie Yu ◽  
Yun Liu ◽  
Shaoming Huang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Raman Spectroscopy ◽  
Boron Nitride ◽  
Surface Enhanced Raman Spectroscopy ◽  
Boron Nitride Nanosheets ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Boron nitride nanosheets covered by gold nanoparticles are controllably fabricated for highly-sensitive and reusable substrates for surface enhanced Raman spectroscopy.

Hierarchical silver mesoparticles with tunable surface topographies for highly sensitive surface-enhanced Raman spectroscopy

2014 ◽  
Vol 2 (13) ◽  
pp. 4534-4542 ◽  
Author(s):  
Lin Cheng ◽  
Chuansheng Ma ◽  
Guang Yang ◽  
Hongjun You ◽  
Jixiang Fang
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Fdtd Simulation ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Topographies ◽  
Surface Enhanced Raman

Using FDTD simulation, the mechanism of the effect of the topographies of hierarchical silver mesoparticles on SERS properties were systematically studied.

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