Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C–N bond cleavage
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The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C–N bond. The protocol is mild, highly functional group tolerant and can be efficiently employed in the synthesis of a broad array of ynones in 48–98% yields under low catalyst loading and Cu-free conditions.
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2004 ◽
Vol 45
(22)
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pp. 4337-4340
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2018 ◽
Vol 5
(18)
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pp. 2734-2738
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2013 ◽
Vol 52
(13)
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pp. 3630-3633
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