Multidimensional (3D/4D-QSAR) probability-guided pharmacophore mapping: investigation of activity profile for a series of drug absorption promoters

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76183-76205 ◽  
Author(s):  
A. Bak ◽  
V. Kozik ◽  
A. Smolinski ◽  
J. Jampilek
Keyword(s):  
Cholic Acid ◽  
Drug Absorption ◽  
Hybrid Approach ◽  
Potential Drug ◽  
Pharmacophore Mapping ◽  
Activity Profile ◽  
Cholic Acid Derivatives

A hybrid approach that combines 3D and 4D-QSAR methods based on grid and neural paradigms with automated IVE-PLS procedure was examined to identify the pharmacophore pattern for cholic acid derivatives as potential drug absorption promoters.

Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers

Steroids ◽  
2011 ◽  
Vol 76 (10-11) ◽  
pp. 1082-1097 ◽  
Author(s):  
Lech Mrózek ◽  
Lenka Dvořáková ◽  
Zuzana Mandelová ◽  
Lucie Rárová ◽  
Anna Řezáčová ◽  
...  
Keyword(s):  
Cholic Acid ◽  
Drug Absorption ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Evaluation of the Cholic Acid Derivatives with Multi-Trifluoroacetylbenzoyl (TFAB) Groups as Carbonate Ionophores.

ChemInform ◽  
2010 ◽  
Vol 30 (30) ◽  
pp. no-no
Author(s):  
Hyung-Jung Pyun ◽  
Junho Chu ◽  
Woojin Yoon ◽  
Young Moo Jun ◽  
Dong Jin Kim
Keyword(s):  
Cholic Acid ◽  
Cholic Acid Derivatives

Preparation of amino acid-appended cholic acid derivatives as sensitizers of Gram-negative bacteria

1999 ◽  
Vol 40 (10) ◽  
pp. 1865-1868 ◽  
Author(s):  
Atiq-ur-Rehman ◽  
Chunhong Li ◽  
Loren P. Budge ◽  
Sarah E. Street ◽  
Paul B. Savage
Keyword(s):  
Amino Acid ◽  
Cholic Acid ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Cholic Acid Derivatives

scholarly journals Synthesis of monosulfates of cholic acid derivatives.

1980 ◽  
Vol 28 (11) ◽  
pp. 3389-3394 ◽  
Author(s):  
JUNICHI GOTO ◽  
HIROAKI KATO ◽  
KIYOSHI KANEKO ◽  
TOSHIO NAMBARA
Keyword(s):  
Cholic Acid ◽  
Cholic Acid Derivatives

Discovery of novel cholic acid derivatives as highly potent agonists for G protein-coupled bile acid receptor

2021 ◽  
pp. 105588
Author(s):  
Mingcheng Qian ◽  
Zhijie Luo ◽  
Wenwen Hou ◽  
Jingjing Sun ◽  
Xin Lu ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Cholic Acid ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
G Protein Coupled ◽  
Cholic Acid Derivatives
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