Multifunctional catalysis: stereoselective construction of α-methylidene-γ-lactams via an amidation/Rauhut–Currier sequence
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One Pot
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Novel chiral organocatalyst 5a, which can simultaneously act as Brønsted and Lewis base catalysts, leads to a one-pot amidation/Rauhut–Currier sequence that affords highly functionalized α-methylidene-γ-lactams with chiral tetrasubstituted carbon stereogenic centers.
Keyword(s):
2020 ◽
Vol 111
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pp. 107666
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