Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407

F. I. Zubkov; E. A. Kvyatkovskaya; E. V. Nikitina; P. N.-A. Amoyaw; V. V. Kouznetsov; V. A. Lazarenko; V. N. Khrustalev

doi:10.1039/c7ob01207a

Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407

Organic & Biomolecular Chemistry ◽

10.1039/c7ob01207a ◽

2017 ◽

Vol 15 (30) ◽

pp. 6447-6450 ◽

Cited By ~ 2

Author(s):

F. I. Zubkov ◽

E. A. Kvyatkovskaya ◽

E. V. Nikitina ◽

P. N.-A. Amoyaw ◽

V. V. Kouznetsov ◽

...

Keyword(s):

Michael Addition ◽

Zebrafish Embryo ◽

The Novel ◽

Unexpected Formation

It has been proved that the reaction between furfuryl amines and N-R-maleimides leads to the formation of aza-Michael addition products – 3-(furylmethylamino)-N-R-pyrrolidine-2,5-diones, instead of 7-oxa-2-azabicyclo[2.2.1]hept-5-enes, as this journal reported previously.

Download Full-text

An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model

Organic & Biomolecular Chemistry ◽

10.1039/c2ob26699g ◽

2013 ◽

Vol 11 (3) ◽

pp. 407-411 ◽

Cited By ~ 12

Author(s):

Carlos E. Puerto Galvis ◽

Vladimir V. Kouznetsov

Keyword(s):

Green Synthesis ◽

Intramolecular Cyclization ◽

Zebrafish Embryo ◽

The Novel ◽

Unexpected Formation ◽

Novel Strategy

An unexpected intramolecular cyclization during the reaction of furfurylamine with maleimides is reported as a novel strategy for the efficient green synthesis of the 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton.

Download Full-text

Stereoselective synthesis of organosulfur compounds incorporating N-aromatic heterocyclic motifs and quaternary carbon centers via a sulfa-Michael triggered tandem reaction

Chemical Communications ◽

10.1039/c5cc01875g ◽

2015 ◽

Vol 51 (47) ◽

pp. 9714-9717 ◽

Cited By ~ 9

Author(s):

Tianyou Qin ◽

Lu Cheng ◽

Sean Xiao-An Zhang ◽

Weiwei Liao

Keyword(s):

Michael Addition ◽

Stereoselective Synthesis ◽

Tandem Reaction ◽

Organosulfur Compounds ◽

The Novel ◽

Quaternary Carbon ◽

Carbon Centers ◽

Aromatic Heterocyclic

The novel sulfa-Michael addition (SMA)-triggered tandem reaction was developed by combining a SMA reaction with a simultaneous rearomatization process.

Download Full-text

Unexpected formation of 5-alkylidene derivatives of hydantoin from the Michael addition of 4-phenylurazole to fumaric esters

Tetrahedron ◽

10.1016/j.tet.2016.02.024 ◽

2016 ◽

Vol 72 (14) ◽

pp. 1736-1741 ◽

Cited By ~ 7

Author(s):

Zahra Soltanzadeh ◽

Gholamhassan Imanzadeh ◽

Nader Noroozi-Pesyan ◽

Ertan Şahin ◽

Hemayat Hooshmand

Keyword(s):

Michael Addition ◽

Unexpected Formation ◽

Derivatives Of ◽

The Michael Addition

Download Full-text

Unexpected formation of the novel mixed μ-oxo, μ-sulfido, bis(μ-thiolato) compound [Mo(IV)2Cp2(μ-O)(μ-S)(μ-SMe)2]

Journal of Organometallic Chemistry ◽

10.1016/s0022-328x(01)00718-5 ◽

2001 ◽

Vol 627 (1) ◽

pp. 67-70 ◽

Cited By ~ 6

Author(s):

Philippe Schollhammer ◽

François Y Pétillon* ◽

Jean Talarmin ◽

Kenneth W Muir*

Keyword(s):

The Novel ◽

Unexpected Formation

Download Full-text

Unexpected regiospecific Michael addition product: synthesis of 5,6-dihydrobenzo[1,7]phenanthrolines

RSC Advances ◽

10.1039/c4ra16640j ◽

2015 ◽

Vol 5 (48) ◽

pp. 38640-38645 ◽

Cited By ~ 15

Author(s):

Selvaraj Mohana Roopan ◽

Annadurai Bharathi ◽

Jeyakannu Palaniraja ◽

K. Anand ◽

R. M. Gengan

Keyword(s):

Michael Addition ◽

Addition Product ◽

Unexpected Formation ◽

First Time

The unexpected formation of 5,6-dihydrobenzo[1,7]phenanthroline instead of 5,6-dihydrobenzo[1,7]phenanthroline-3-carbonitrile in acridine molecules using Michael addition has been observed for the first time.

Download Full-text

Synthesis, Characterization, and Drug Encapsulation of Hyperbranched Polyamidoamine Modified by β-Cyclodextrin

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.718-720.267 ◽

2013 ◽

Vol 718-720 ◽

pp. 267-270

Author(s):

Xiao Long Jiang ◽

Mi Zhou ◽

Xiao Feng Ye ◽

Xin Qian

Keyword(s):

Michael Addition ◽

Hyperbranched Polymer ◽

Inclusion Complexation ◽

The Novel ◽

Drug Encapsulation ◽

H Nmr ◽

Potential Applications ◽

Ester Aminolysis ◽

The Michael Addition ◽

Ubbelohde Viscometer

h-PAMAM-COOMe and its β-CD derivatives (h-PAMAM-CD) were synthesized step by step via the Michael addition and ester-aminolysis reaction from hyperbranched polyamidoamine (h-PAMAM). The structures of the as-prepared polymers were confirmed by Ubbelohde viscometer, FTIR, and 1H NMR. A series of inclusion complexation formed by β-naphtol in increasing h-PAMAM-β-CD with different concerntration were investigated by UV-vis spectrometer. The result showed that the novel hyperbranched polymer might have potential applications as delivery materials in chemotherapy.

Download Full-text