Solution growth and thermal treatment of crystals lead to two new forms of 2-((2,6-dimethylphenyl)amino)benzoic acid

Two new forms of a potential non-steroidal anti-inflammatory and thyroid drug, 2-((2,6-dimethylphenyl)amino)benzoic acid were discovered and investigated experimentally and theoretically.

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Comment on ‘Solution growth and thermal treatment of crystals lead to two new forms of 2-((2,6-dimethylphenyl)amino)benzoic acid’ by R. Hu, Y. Zhoujin, M. Liu, M. Zhang, S. Parkin, P. Zhou, J. Wang, F. Yu and S. Long, RSC Adv., 2018, 8, 15459

RSC Advances ◽

10.1039/c8ra07188h ◽

2019 ◽

Vol 9 (48) ◽

pp. 28195-28198 ◽

Cited By ~ 1

Author(s):

Paulo R. S. Salbego ◽

Tainára Orlando ◽

Marcos A. P. Martins

Keyword(s):

Crystal Structure ◽

Thermal Treatment ◽

Benzoic Acid ◽

Structure Refinement ◽

Solution Growth ◽

Amino Benzoic Acid

The two polymorphs reported by Long et al. are discussed point by point, suggesting that the newly reported crystal structure is in fact the same structure previously reported, differing in how the structure refinement was performed.

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Correction: Solution growth and thermal treatment of crystals lead to two new forms of 2-((2,6-dimethylphenyl)amino)benzoic acid

RSC Advances ◽

10.1039/d0ra90012e ◽

2020 ◽

Vol 10 (8) ◽

pp. 4464-4464

Author(s):

Rong Hu ◽

Yunping Zhoujin ◽

Meng Liu ◽

Mingtao Zhang ◽

Sean Parkin ◽

...

Keyword(s):

Thermal Treatment ◽

Benzoic Acid ◽

Solution Growth ◽

Amino Benzoic Acid

Correction for ‘Solution growth and thermal treatment of crystals lead to two new forms of 2-((2,6-dimethylphenyl)amino)benzoic acid’ by Rong Hu et al., RSC Adv., 2018, 8, 15459–15470.

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CrystEngComm - Invitation to Submit Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems

CrystEngComm ◽

10.1039/d1ce01407b ◽

2022 ◽

Author(s):

Yunping Zhoujin ◽

Yuping Li ◽

Mingtao Zhang ◽

Sean R. Parkin ◽

Ju Guo ◽

...

Keyword(s):

Benzoic Acid ◽

Salt Formation ◽

Inflammatory Drug ◽

Two Systems ◽

Anti Inflammatory ◽

Its Polymorphism ◽

Amino Benzoic Acid

2-((2,6-Dichlorophenyl)amino)benzoic acid (2-DCABA), a potential non-steroidal anti-inflammatory drug and an analog of 2-((2,6-dimethylphenyl)amino)benzoic acid (HDMPA) was synthesized and its polymorphism was studied to investigate the effect of double Cl-CH3 exchange....

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Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(03)00529-7 ◽

2003 ◽

Vol 11 (23) ◽

pp. 5281-5291 ◽

Cited By ~ 11

Author(s):

Ashok Kumar ◽

Deepti Bansal ◽

Kiran Bajaj ◽

Shalabh Sharma ◽

Archana ◽

...

Keyword(s):

Benzoic Acid ◽

Analgesic Agents ◽

Anti Inflammatory ◽

Derivatives Of ◽

Amino Benzoic Acid

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Synthesis and Anti-inflammatory Activity of Some Novel 3-(6-Substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4 (3H)-ones

E-Journal of Chemistry ◽

10.1155/2009/507052 ◽

2009 ◽

Vol 6 (4) ◽

pp. 1055-1062 ◽

Cited By ~ 9

Author(s):

Manish Srivastav ◽

MD. Salahuddin ◽

S. M. Shantakumar

Keyword(s):

Antibacterial Activity ◽

Benzoic Acid ◽

Spectral Data ◽

Elemental Analysis ◽

Inflammatory Activity ◽

Mass Spectral Data ◽

Mass Spectral ◽

Anti Inflammatory ◽

Substituted 1 ◽

Amino Benzoic Acid

A series of novel 3-(6-substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4(3H)-ones were synthesized by treating 2-(chloromethyl)-3-(6-substituted-1, 3-benzothiazole-2-yl) quinazoline-4-(3H)-one (IIa-d) with various substituted amine. The compounds (IIa-d) prepared by treating 2-[(chloroacetyl) amino] benzoic acid with different 2-amino-6-substituted benzothiazole. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolines-4-one derivative were investigated for their anti-inflammatory and antibacterial activity.

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