Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents

2003 ◽  
Vol 11 (23) ◽  
pp. 5281-5291 ◽  
Author(s):  
Ashok Kumar ◽  
Deepti Bansal ◽  
Kiran Bajaj ◽  
Shalabh Sharma ◽  
Archana ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Derivatives Of ◽  
Amino Benzoic Acid

scholarly journals Novel Ester and Acid Derivatives of the 1,5-Diarylpyrrole Scaffold as Anti-Inflammatory and Analgesic Agents. Synthesis and in Vitro and in Vivo Biological Evaluation

2010 ◽  
Vol 53 (2) ◽  
pp. 723-733 ◽  
Author(s):  
Mariangela Biava ◽  
Giulio C. Porretta ◽  
Giovanna Poce ◽  
Claudio Battilocchio ◽  
Fabrizio Manetti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Derivatives Of

CrystEngComm - Invitation to Submit Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems

CrystEngComm ◽  
2022 ◽  
Author(s):  
Yunping Zhoujin ◽  
Yuping Li ◽  
Mingtao Zhang ◽  
Sean R. Parkin ◽  
Ju Guo ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Salt Formation ◽  
Inflammatory Drug ◽  
Two Systems ◽  
Anti Inflammatory ◽  
Its Polymorphism ◽  
Amino Benzoic Acid

2-((2,6-Dichlorophenyl)amino)benzoic acid (2-DCABA), a potential non-steroidal anti-inflammatory drug and an analog of 2-((2,6-dimethylphenyl)amino)benzoic acid (HDMPA) was synthesized and its polymorphism was studied to investigate the effect of double Cl-CH3 exchange....

scholarly journals Solution growth and thermal treatment of crystals lead to two new forms of 2-((2,6-dimethylphenyl)amino)benzoic acid

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15459-15470 ◽  
Author(s):  
Rong Hu ◽  
Yunping Zhoujin ◽  
Meng Liu ◽  
Mingtao Zhang ◽  
Sean Parkin ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Benzoic Acid ◽  
Solution Growth ◽  
Anti Inflammatory ◽  
Amino Benzoic Acid

Two new forms of a potential non-steroidal anti-inflammatory and thyroid drug, 2-((2,6-dimethylphenyl)amino)benzoic acid were discovered and investigated experimentally and theoretically.

scholarly journals Synthesis and Anti-inflammatory Activity of Some Novel 3-(6-Substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4 (3H)-ones

2009 ◽  
Vol 6 (4) ◽  
pp. 1055-1062 ◽  
Author(s):  
Manish Srivastav ◽  
MD. Salahuddin ◽  
S. M. Shantakumar
Keyword(s):  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Inflammatory Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Substituted 1 ◽  
Amino Benzoic Acid

A series of novel 3-(6-substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4(3H)-ones were synthesized by treating 2-(chloromethyl)-3-(6-substituted-1, 3-benzothiazole-2-yl) quinazoline-4-(3H)-one (IIa-d) with various substituted amine. The compounds (IIa-d) prepared by treating 2-[(chloroacetyl) amino] benzoic acid with different 2-amino-6-substituted benzothiazole. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolines-4-one derivative were investigated for their anti-inflammatory and antibacterial activity.

scholarly journals Synthesis of Some 4,5-Dihydrothieno[3,2-e][1,2,4]Triazolo[4,3-a] Pyrimi-dine-2-Carboxamides as Anti-Inflammatory and Analgesic Agents

2013 ◽  
Vol 7 (1) ◽  
pp. 49-65 ◽  
Author(s):  
Omaima G. Shaaban ◽  
Ola H. Rizk ◽  
Aida E. Bayad ◽  
Ibrahim M. El-Ashmawy
Keyword(s):  
Analgesic Activity ◽  
Safety Margin ◽  
Docking Study ◽  
Inflammatory Activity ◽  
Onset Of Action ◽  
Safety Level ◽  
Active Compounds ◽  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Derivatives Of

A new series 4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidine-2-carboxamide was synthesized. Twenty one newly synthesized compounds were investigated for their anti-inflammatory and analgesic activity using acute and subacute formalin-induced paw edema models and diclofenac Na as a reference. The acute toxicity (ALD50) and ulcerogenic effects of the active compounds were also determined. The thienotriazolopyrimidines 10a, 10c and 11c were found to exhibit remarkable anti-inflammatory activity at both models in addition to good analgesic activity with a delayed onset of action. Moreover, the active compounds showed high GI safety level and are well tolerated by experimental animals with high safety margin (ALD50 > 0.4 g/kg). Docking study using Molecular Operating Environment (MOE) version 2008.10 into COX-2 has been made for derivatives of highest anti-inflammatory activity.

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