Asymmetric organocatalytic synthesis of chiral 3,3-disubstituted oxindolesviaa 1,6-conjugate addition reaction

2018 ◽  
Vol 16 (29) ◽  
pp. 5301-5309 ◽  
Author(s):  
Abdul Rahman ◽  
Qiaoxia Zhou ◽  
Xufeng Lin
Keyword(s):  
Phosphoric Acid ◽  
Addition Reaction ◽  
Conjugate Addition ◽  
Quinone Methides ◽  
Acid Catalyzed

The chiral spirocyclic phosphoric acid-catalyzed enantioselective 1,6-conjugate addition reaction ofpara-quinone methides derived fromN-unprotected isatins with indoles was developed.

ChemInform Abstract: Phosphoric Acid Catalyzed Asymmetric 1,6-Conjugate Addition of Thioacetic Acid to para-Quinone Methides.

ChemInform ◽  
2016 ◽  
Vol 47 (22) ◽  
Author(s):  
Nan Dong ◽  
Zhi-Pei Zhang ◽  
Xiao-Song Xue ◽  
Xin Li ◽  
Jin-Pei Cheng
Keyword(s):  
Phosphoric Acid ◽  
Conjugate Addition ◽  
Thioacetic Acid ◽  
Quinone Methides ◽  
Acid Catalyzed

Phosphoric Acid Catalyzed Asymmetric 1,6-Conjugate Addition of Thioacetic Acid to para -Quinone Methides

2015 ◽  
Vol 55 (4) ◽  
pp. 1460-1464 ◽  
Author(s):  
Nan Dong ◽  
Zhi-Pei Zhang ◽  
Xiao-Song Xue ◽  
Xin Li ◽  
Jin-Pei Cheng
Keyword(s):  
Phosphoric Acid ◽  
Conjugate Addition ◽  
Thioacetic Acid ◽  
Quinone Methides ◽  
Acid Catalyzed

Phosphoric Acid Catalyzed Asymmetric 1,6-Conjugate Addition of Thioacetic Acid to para -Quinone Methides

2015 ◽  
Vol 128 (4) ◽  
pp. 1482-1486 ◽  
Author(s):  
Nan Dong ◽  
Zhi-Pei Zhang ◽  
Xiao-Song Xue ◽  
Xin Li ◽  
Jin-Pei Cheng
Keyword(s):  
Phosphoric Acid ◽  
Conjugate Addition ◽  
Thioacetic Acid ◽  
Quinone Methides ◽  
Acid Catalyzed

Organocatalytic site- and stereoselective 1,6-additions of N-aryl-3-oxobutanamides to propargylic aza-p-quinone methides

2020 ◽  
Vol 7 (21) ◽  
pp. 3446-3451
Author(s):  
Fushuai Li ◽  
Xuling Chen ◽  
Shuai Liang ◽  
Zhenyan Shi ◽  
Pengfei Li ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Conjugate Addition ◽  
Quinone Methides ◽  
Propargylic Alcohols ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed ◽  
Site Selective ◽  
First Time

A chiral phosphoric acid catalyzed site-selective 1,6-conjugate addition of N-aryl-3-oxobutanamides to in situ formed propargylic aza-p-quinone methides from propargylic alcohols has been established for the first time.

scholarly journals Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides

Synlett ◽  
2018 ◽  
Vol 30 (04) ◽  
pp. 483-487 ◽  
Author(s):  
Shuo Tong ◽  
Mei-Xiang Wang
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Nucleophilic Addition ◽  
Addition Reaction ◽  
Enantioselective Synthesis ◽  
Chiral Phosphoric Acid ◽  
Substrate Engineering ◽  
Nucleophilic Addition Reaction ◽  
Engineering Strategy ◽  
Acid Catalyzed

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

Chiral Spiro Phosphoric Acid-Catalyzed Friedel–Crafts Conjugate Addition/Enantioselective Protonation Reactions

ACS Catalysis ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 6522-6529 ◽  
Author(s):  
Yi-Pan Li ◽  
Zi-Qi Li ◽  
Biying Zhou ◽  
Mao-Lin Li ◽  
Xiao-Song Xue ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Conjugate Addition ◽  
Acid Catalyzed
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