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Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 56
Author(s):  
Haiqing Wan ◽  
Xianbo Xiao ◽  
Yee Sin Ang

We study the quantum transport properties of graphene nanoribbons (GNRs) with a different edge doping strategy using density functional theory combined with nonequilibrium Green’s function transport simulations. We show that boron and nitrogen edge doping on the electrodes region can substantially modify the electronic band structures and transport properties of the system. Remarkably, such an edge engineering strategy effectively transforms GNR into a molecular spintronic nanodevice with multiple exceptional transport properties, namely: (i) a dual spin filtering effect (SFE) with 100% filtering efficiency; (ii) a spin rectifier with a large rectification ratio (RR) of 1.9 ×106; and (iii) negative differential resistance with a peak-to-valley ratio (PVR) of 7.1 ×105. Our findings reveal a route towards the development of high-performance graphene spintronics technology using an electrodes edge engineering strategy.


Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 3
Author(s):  
Ashita Nair ◽  
Jiyoon Bu ◽  
Piper A. Rawding ◽  
Steven C. Do ◽  
Hangpeng Li ◽  
...  

Extracellular vesicles (EVs) have been highlighted as novel drug carriers due to their unique structural properties and intrinsic features, including high stability, biocompatibility, and cell-targeting properties. Although many efforts have been made to harness these features to develop a clinically effective EV-based therapeutic system, the clinical translation of EV-based nano-drugs is hindered by their low yield and loading capacity. Herein, we present an engineering strategy that enables upscaled EV production with increased loading capacity through the secretion of EVs from cells via cytochalasin-B (CB) treatment and reduction of EV intravesicular contents through hypo-osmotic stimulation. CB (10 µg/mL) promotes cells to extrude EVs, producing ~three-fold more particles than through natural EV secretion. When CB is induced in hypotonic conditions (223 mOsm/kg), the produced EVs (hypo-CIMVs) exhibit ~68% less intravesicular protein, giving 3.4-fold enhanced drug loading capacity compared to naturally secreted EVs. By loading doxorubicin (DOX) into hypo-CIMVs, we found that hypo-CIMVs efficiently deliver their drug cargos to their target and induce up to ~1.5-fold more cell death than the free DOX. Thus, our EV engineering offers the potential for leveraging EVs as an effective drug delivery vehicle for cancer treatment.


2021 ◽  
Vol 478 (23) ◽  
pp. 4093-4097
Author(s):  
Matthew J. Guberman-Pfeffer ◽  
Nikhil S. Malvankar

Every living cell needs to get rid of leftover electrons when metabolism extracts energy through the oxidation of nutrients. Common soil microbes such as Geobacter sulfurreducens live in harsh environments that do not afford the luxury of soluble, ingestible electron acceptors like oxygen. Instead of resorting to fermentation, which requires the export of reduced compounds (e.g. ethanol or lactate derived from pyruvate) from the cell, these organisms have evolved a means to anaerobically respire by using nanowires to export electrons to extracellular acceptors in a process called extracellular electron transfer (EET) [ 1]. Since 2005, these nanowires were thought to be pili filaments [ 2]. But recent studies have revealed that nanowires are composed of multiheme cytochromes OmcS [ 3, 4] and OmcZ [ 5] whereas pili remain inside the cell during EET and are required for the secretion of nanowires [ 6]. However, how electrons are passed to these nanowires remains a mystery ( Figure 1A). Periplasmic cytochromes (Ppc) called PpcA-E could be doing the job, but only two of them (PpcA and PpcD) can couple electron/proton transfer — a necessary condition for energy generation. In a recent study, Salgueiro and co-workers selectively replaced an aromatic with an aliphatic residue to couple electron/proton transfer in PpcB and PpcE (Biochem. J. 2021, 478 (14): 2871–2887). This significant in vitro success of their protein engineering strategy may enable the optimization of bioenergetic machinery for bioenergy, biofuels, and bioelectronics applications.


2021 ◽  
Author(s):  
Gang Li ◽  
Yuqian Huang ◽  
Rongfeng Tang ◽  
Bo Che ◽  
Peng Xiao ◽  
...  

Abstract Carrier separation in a solar cell usually relies on the p-n junction. Here we show that n-n type inorganic semiconductor heterojunction is also able to separate the exciton for efficient solar cell applications. The n-n type heterojunction was formed by hydrothermal deposition of Sb2(S,Se)3 and thermal evaporation of Sb2Se3. We found that the n-n junction is able to enhance the carrier separation by the formation of an electric field, reduce the interfacial recombination and generate optimized band alignment. The device based on this n-n junction shows 2.89% net efficiency improvement to 7.75% when compared with the device consisted of semiconductor absorber-metal contact. The study in the n-n type solar cell is expected to bring about more versatile materials utility, new interfacial engineering strategy and fundamental findings in the photovoltaic energy conversion process.


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Bin Li ◽  
Xiaotan Zhang ◽  
Tingting Wang ◽  
Zhangxing He ◽  
Bingan Lu ◽  
...  

AbstractDue to their high safety and low cost, rechargeable aqueous Zn-ion batteries (RAZIBs) have been receiving increased attention and are expected to be the next generation of energy storage systems. However, metal Zn anodes exhibit a limited-service life and inferior reversibility owing to the issues of Zn dendrites and side reactions, which severely hinder the further development of RAZIBs. Researchers have attempted to design high-performance Zn anodes by interfacial engineering, including surface modification and the addition of electrolyte additives, to stabilize Zn anodes. The purpose is to achieve uniform Zn nucleation and flat Zn deposition by regulating the deposition behavior of Zn ions, which effectively improves the cycling stability of the Zn anode. This review comprehensively summarizes the reaction mechanisms of interfacial modification for inhibiting the growth of Zn dendrites and the occurrence of side reactions. In addition, the research progress of interfacial engineering strategies for RAZIBs is summarized and classified. Finally, prospects and suggestions are provided for the design of highly reversible Zn anodes.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Franka H. van der Linden ◽  
Eike K. Mahlandt ◽  
Janine J. G. Arts ◽  
Joep Beumer ◽  
Jens Puschhof ◽  
...  

AbstractThe most successful genetically encoded calcium indicators (GECIs) employ an intensity or ratiometric readout. Despite a large calcium-dependent change in fluorescence intensity, the quantification of calcium concentrations with GECIs is problematic, which is further complicated by the sensitivity of all GECIs to changes in the pH in the biological range. Here, we report on a sensing strategy in which a conformational change directly modifies the fluorescence quantum yield and fluorescence lifetime of a circular permutated turquoise fluorescent protein. The fluorescence lifetime is an absolute parameter that enables straightforward quantification, eliminating intensity-related artifacts. An engineering strategy that optimizes lifetime contrast led to a biosensor that shows a 3-fold change in the calcium-dependent quantum yield and a fluorescence lifetime change of 1.3 ns. We dub the biosensor Turquoise Calcium Fluorescence LIfeTime Sensor (Tq-Ca-FLITS). The response of the calcium sensor is insensitive to pH between 6.2–9. As a result, Tq-Ca-FLITS enables robust measurements of intracellular calcium concentrations by fluorescence lifetime imaging. We demonstrate quantitative imaging of calcium concentrations with the turquoise GECI in single endothelial cells and human-derived organoids.


2021 ◽  
pp. 117330
Author(s):  
Qiang Huang ◽  
Xinxin Li ◽  
Pengpeng Zhang ◽  
Shichao Zhang ◽  
Yahua Liu ◽  
...  

2021 ◽  
Vol 6 (3) ◽  
pp. 102-118
Author(s):  
Jacob Kithinji ◽  
Gladys Rotich ◽  
Allan Kihara

Purpose: Most of the large manufacturing firms in Kenya have been experiencing declining performance in terms of revenue, sales and the profit margins for more than a decade. This has seen some of the large manufacturing firms in the country consider strategies such as relocating or restructuring their operations, opting to serve the local market through importing from low-cost manufacturing areas instead of adopting turnaround strategies. This therefore prompted a question on whether turnaround strategies such as reengineering strategy are effective for the manufacturing firms; hence the motivation of this study. Methodology: This study was informed by theory of constraints. A descriptive research design was adopted while 708 large manufacturing firms in Kenya registered under the Kenya Association of Manufacturers were targeted. The sample size for the study was 249 firms selected randomly from all the 14 sectors of the manufacturing industry in Kenya. The data collection instrument was a questionnaire, while mean, frequencies and percentages were used to describe the data. Correlation and regression analysis were done to show direction, magnitude and significance of the association between the variables. Findings: The findings revealed that re-engineering strategy had significant and positive influence on the performance of large manufacturing firms in Kenya. The findings further revealed that organizational culture had significant moderating effect on the relationship between reengineering strategy and performance of large manufacturing companies. The study concluded that reengineering strategy as one of the turnaround strategies positively influenced the performance of large manufacturing companies. Unique Contribution to Theory, Practice and Policy: It is therefore recommended that the management of large manufacturing firms uphold reengineering strategy in order to enhance performance.


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