Synthesis and biological evaluation of 2-aryl-benzimidazole derivatives of dehydroabietic acid as novel tubulin polymerization inhibitors

A series of novel 2-aryl-benzimidazole derivatives of dehydroabietic acid were synthesized. Among them, compound 6j was found to be a potent tubulin polymerization inhibitor.

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Hybrid Pharmacophore Design, Molecular Docking, Synthesis, and Biological Evaluation of Novel Aldimine-Type Schiff Base Derivatives as Tubulin Polymerization Inhibitor

Chemistry & Biodiversity ◽

10.1002/cbdv.201700518 ◽

2018 ◽

Vol 15 (3) ◽

pp. e1700518 ◽

Cited By ~ 5

Author(s):

Alieh Ameri ◽

Ghadamali Khodarahmi ◽

Hamid Forootanfar ◽

Farshid Hassanzadeh ◽

Gholam-Hosein Hakimelahi

Keyword(s):

Schiff Base ◽

Molecular Docking ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

Schiff Base Derivatives ◽

Polymerization Inhibitor ◽

Tubulin Polymerization Inhibitor ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinoline Compounds as New Tubulin Polymerization Inhibitors

International Journal of Molecular Sciences ◽

10.3390/ijms160510173 ◽

2015 ◽

Vol 16 (12) ◽

pp. 10173-10184 ◽

Cited By ~ 1

Author(s):

Ling Zhang ◽

Yunlong Song ◽

Jingjing Huang ◽

Jia Liu ◽

Wenwen Zhu ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of Novel Acridine and Quinoline Derivatives as Tubulin Polymerization Inhibitors with Anticancer Activities

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116376 ◽

2021 ◽

pp. 116376

Author(s):

Yichang Ren ◽

Yong Ruan ◽

Binbin Cheng ◽

Ling Li ◽

Jin Liu ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Quinoline Derivatives ◽

Anticancer Activities ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.11.010 ◽

2018 ◽

Vol 143 ◽

pp. 216-231 ◽

Cited By ~ 23

Author(s):

P.V. Sri Ramya ◽

Lalita Guntuku ◽

Srinivas Angapelly ◽

Chander Singh Digwal ◽

Uppu Jaya Lakshmi ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.12.053 ◽

2019 ◽

Vol 168 ◽

pp. 426-435 ◽

Cited By ~ 14

Author(s):

Min'an Zhai ◽

Shiyuan Liu ◽

Meiqi Gao ◽

Long Wang ◽

Jun Sun ◽

...

Keyword(s):

Rational Design ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis, biological evaluation, and molecular docking studies of novel 1-benzene acyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as potential tubulin polymerization inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2015.05.021 ◽

2015 ◽

Vol 99 ◽

pp. 125-137 ◽

Cited By ~ 25

Author(s):

Yan-Ting Wang ◽

Ya-Juan Qin ◽

Na Yang ◽

Ya-Liang Zhang ◽

Chang-Hong Liu ◽

...

Keyword(s):

Molecular Docking ◽

Docking Studies ◽

Biological Evaluation ◽

Benzimidazole Derivatives ◽

Tubulin Polymerization ◽

Molecular Docking Studies ◽

Tubulin Polymerization Inhibitors

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Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112625 ◽

2020 ◽

Vol 204 ◽

pp. 112625 ◽

Cited By ~ 1

Author(s):

Fang Yang ◽

Xie-Er Jian ◽

Peng-Cheng Diao ◽

Xian-Sen Huo ◽

Wen-Wei You ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of Schizandrin derivatives as tubulin polymerization inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127354 ◽

2020 ◽

Vol 30 (16) ◽

pp. 127354

Author(s):

G. Dileep Kumar ◽

B. Siva ◽

K. Bharathi ◽

A. Devi ◽

P. Pavan Kumar ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.111577 ◽

2019 ◽

Vol 181 ◽

pp. 111577 ◽

Cited By ~ 8

Author(s):

Romeo Romagnoli ◽

Paola Oliva ◽

Maria Kimatrai Salvador ◽

Maria Encarnacion Camacho ◽

Chiara Padroni ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of 1-(benzofuran-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole derivatives as tubulin polymerization inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.103392 ◽

2020 ◽

Vol 94 ◽

pp. 103392 ◽

Cited By ~ 3

Author(s):

Zhi-Yuan Qi ◽

Shu-Yi Hao ◽

Heng-Zhi Tian ◽

Hong-Li Bian ◽

Ling Hui ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Triazole Derivatives ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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