Enantioseparation of amino alcohol drugs by nonaqueous capillary electrophoresis with a maltobionic acid-based ionic liquid as the chiral selector

The Analyst ◽  
2019 ◽  
Vol 144 (24) ◽  
pp. 7468-7477 ◽  
Author(s):  
Xiaofei Ma ◽  
Zigui Kan ◽  
Yingxiang Du ◽  
Jiangxia Yang ◽  
Zijie Feng ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Amino Alcohol ◽  
Chiral Selector ◽  
The Novel ◽  
Nonaqueous Capillary Electrophoresis ◽  
Capillary Electrophoretic

This study deals with the nonaqueous capillary electrophoretic enantioseparation of twenty-two amino alcohol drugs with a maltobionic acid (MA)-based ionic liquid (tetramethylammonium maltobionic acid, TMA-MA) as the novel chiral selector.

Analysis of aromatic acids by nonaqueous capillary electrophoresis with ionic-liquid electrolytes

2014 ◽  
Vol 35 (23) ◽  
pp. 3310-3316 ◽  
Author(s):  
Yuanqi Lu ◽  
Dunqing Wang ◽  
Chunyan Kong ◽  
Hao Zhong ◽  
Michael C. Breadmore
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Aromatic Acids ◽  
Nonaqueous Capillary Electrophoresis ◽  
Liquid Electrolytes

Clarithromycin as a chiral selector for enantioseparation of basic compounds in nonaqueous capillary electrophoresis

2014 ◽  
Vol 35 (19) ◽  
pp. 2759-2764 ◽  
Author(s):  
Margarita V. Lebedeva ◽  
Aleksandra F. Prokhorova ◽  
Elena N. Shapovalova ◽  
Oleg A. Shpigun
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Nonaqueous Capillary Electrophoresis ◽  
Basic Compounds

L-Histidinium Chiral Ionic Liquid Functionalized β-Cyclodextrin as Chiral Selector in Capillary Electrophoresis

2021 ◽  
Author(s):  
Xiaofei Ma ◽  
Jingtang Li ◽  
Xiaoqi Li ◽  
Zijie Feng ◽  
Xuan Yang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Ionic Liquids ◽  
Molecular Modeling ◽  
Chiral Separation ◽  
Chiral Selector ◽  
Chiral Discrimination ◽  
Chiral Ionic Liquid ◽  
First Time ◽  
Good Agreement

Abstract Nowadays, ionic liquids (ILs) functionalized cyclodextrins (CDs) have drawn increasing attention in chiral separation. Herein, a novel β-CD derivative functionalized by L-histidinium IL, mono-6-deoxy-6-L-histidinium-β-cyclodextrin chloride (L-HMCDCl), was synthesized for the first time and utilized for enantioseparation of nefopam and chlorphenamine in capillary electrophoresis. The L-HMCDCl exhibited superior enantioselectivity compared with native β-CD. The effect of some key parameters such as chiral selector concentration, buffer pH and applied voltage on the enantioseparation was investigated in detail. In the interest of the chiral discrimination mechanism and the enhanced enantioselectivity of L-HMCDCl, molecular modeling with AutoDock was employed to study the interaction, which was in good agreement with experimental results.

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