Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome

2020 ◽  
Vol 11 (7) ◽  
pp. 6104-6114
Author(s):  
Chong Guo ◽  
Yumin He ◽  
Liyue Gai ◽  
Jiayuan Qu ◽  
Yue Shi ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Alimentary Tract ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Folk Medicine ◽  
Experimental Colitis ◽  
Local People

Balanophora polyandra Griff. (B. polyandra) is a folk medicine used as an antipyretic, antidote, haemostatic, dressing and haematic tonic, for the treatment of gonorrhea, syphilis, wounds, and the bleeding of the alimentary tract by the local people in China.

scholarly journals Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome

2019 ◽  
Vol 110 ◽  
pp. 786-795 ◽  
Author(s):  
Peng Shen ◽  
Zecai Zhang ◽  
Kunpeng Zhu ◽  
Hongyang Cao ◽  
Jiuxi Liu ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Experimental Colitis

scholarly journals Natural naphthoquinones isolated from Lithospermum erythrorhizon suppress dextran sulfate sodium-induced murine experimental colitis

2019 ◽  
Author(s):  
Wenxue Sun ◽  
Hongwei Han ◽  
Zhaoyue Wang ◽  
Zhongling Wen ◽  
Minkai Yang ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Active Sites ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Activity Index ◽  
Docking Simulation ◽  
Disease Activity Index ◽  
Experimental Colitis ◽  
Intragastric Administration ◽  
Underlying Mechanisms

AbstractThe purpose of this study was to explore the effects of natural shikonin and its derivatives on mice experimental colitis induced by dextran sulfate sodium, and to investigate the underlying mechanisms in vivo. Our results suggested that, intragastric administration of single compound like shikonin and its derivatives contributed to attenuating symptoms of malignant induced by DSS. Meanwhile, shikonin or its derivatives could also remarkably reduce the disease activity index and histopathological scores, suppress the levels of pro-inflammatory cytokines (including IL-6, IL-1β and TNF-α), while increase that of inflammatory cytokine IL-10 in serum. Additionally, both shikonin and alkanin were found to restrain the levels of COX-2, MPO and iNOS in serum and colonic tissues. Moreover, western blotting results demonstrated that shikonin and its derivatives could inhibit the activation of the NLRP3 inflammasome and the NF-κB signaling pathway, relieve the DSS-induced disruption of colonic epithelial tight junction (TJ) in colonic tissues. Further, docking simulation had been performed to prove that shikonin and its derivatives could bind to the active sites of NLRP3 inflammasome and the NF-κB to generate an effective inflammatory effect. Taken together, our experimental data can provide some evidence for the potential use of shikonin and its derivatives to treat the inflammatory bowel disease (IBD).

scholarly journals Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition

2015 ◽  
Vol 129 (2) ◽  
pp. 101-106 ◽  
Author(s):  
Wenjie Guo ◽  
Shasha Hu ◽  
Ahmed Elgehama ◽  
Fenli Shao ◽  
Ren Ren ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Experimental Colitis

scholarly journals Intestinal mesenchymal cells regulate immune responses and promote epithelial regeneration in vitro and in dextran sulfate sodium‐induced experimental colitis in mice

2021 ◽  
Author(s):  
Laura Hidalgo‐Garcia ◽  
José Alberto Molina‐Tijeras ◽  
Francisco Huertas‐Peña ◽  
Antonio Jesús Ruiz‐Malagón ◽  
Patricia Diez‐Echave ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Experimental Colitis ◽  
Mesenchymal Cells ◽  
Epithelial Regeneration ◽  
Regeneration In Vitro
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