Facile template synthesis of water-soluble triazine-based Schiff base ligand bridged-coordination polymers of Co(ii), Ni(ii), and Cu(ii): structure, biomolecular interactions, and cytotoxic activity

2019 ◽  
Vol 43 (34) ◽  
pp. 13371-13380 ◽  
Author(s):  
Sheikdawood Parveen ◽  
Thathan Premkumar ◽  
Hung Huy Nguyen ◽  
Subbiah Govindarajan
Keyword(s):  
Schiff Base ◽  
Cytotoxic Activity ◽  
Coordination Polymers ◽  
Schiff Base Ligand ◽  
Template Synthesis ◽  
Water Soluble ◽  
Biomolecular Interactions ◽  
First Time ◽  
Ct Dna

For the first time, a new hydrazone Schiff base ligand and its Co(ii), Ni(ii), and Cu(ii) complexes were synthesised and characterised. Their antioxidant and binding activities towards CT-DNA and BSA were evaluated.

Spectrophotometric Study on the Binding of Two Water Soluble Schiff Base Complexes of Mn (III) with ct-DNA

2011 ◽  
Vol 21 (4) ◽  
pp. 1649-1658 ◽  
Author(s):  
Maryam Nejat Dehkordi ◽  
Abdol-Khlegh Bordbar ◽  
Masood Ayatolahi Mehrgardi ◽  
Valiolah Mirkhani
Keyword(s):  
Schiff Base ◽  
Spectrophotometric Study ◽  
Water Soluble ◽  
Schiff Base Complexes ◽  
Ct Dna

scholarly journals Synthesis and Spectroscopic Investigations of Schiff Base Ligand and Its Bimetallic Ag(I) Complex as DNA and BSA Binders

Biomolecules ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1449
Author(s):  
Martyna Szymańska ◽  
Izabela Pospieszna-Markiewicz ◽  
Martyna Mańka ◽  
Małgorzata Insińska-Rak ◽  
Grzegorz Dutkiewicz ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Building Blocks ◽  
Schiff Base Ligands ◽  
Design Synthesis ◽  
Coordination Sites ◽  
Cd Studies ◽  
Α Helix ◽  
Ct Dna

Generation of well-defined potential metallotherapeutics for cancer treatment, one of the most population-threatening diseases, is challenging and an active area of modern research in view of their unique properties and thus multiple possible pathways of action in cells. Specifically, Schiff base ligands were recognized as very promising building blocks for the construction of stable and active complexes of numerous geometries and topologies. Incorporation of Ag(I) ions allows for the formation of flat complexes with potential unoccupied coordination sites, thus giving rise to specific interactions between the metallotherapeutic and biomolecule of interest. Herein, we present the design, synthesis and characterization of new Schiff base ligand L and its Ag(I) bimetallic complex [Ag2L2]2+ with two planar moieties formed around the metal ions and connected through cyclohexane rings, confirmed by X-ray measurements. The compounds were described in context of their potential use as anticancer drugs through DNA and BSA binding pathways by several spectroscopic methods (CD, UV-Vis, fluorescence). We revealed that both, L and [Ag2L2]2+, interact with similar affinity with CT-DNA (Kb~106 M−1), while they differ in the type and strength of interactions with the model albumin–BSA. [Ag2L2]2+ binds BSA in both a dynamic and static manner with the Ksv = 8.8 × 104 M−1 in the Trp-134 and Trp-213 sites, whereas L interacts with BSA only dynamically (KSV = 2.4 × 104 M−1). This found further confirmation in the CD studies which revealed a reduction in α-helix content in the albumin of 16% in presence of [Ag2L2]2+.

Anion influence in the structural diversity of cadmium coordination polymers constructed from a pyridine based Schiff base ligand

2015 ◽  
Vol 427 ◽  
pp. 87-96 ◽  
Author(s):  
Ali Akbar Khandar ◽  
Farhad Akbari Afkhami ◽  
Seyed Abolfazl Hosseini-Yazdi ◽  
Jonathan M. White ◽  
Scott Kassel ◽  
...  
Keyword(s):  
Schiff Base ◽  
Coordination Polymers ◽  
Schiff Base Ligand ◽  
Structural Diversity
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