Weak coordinated nitrogen functionality enabled regioselective C–H alkynylation via Pd(ii)/mono-N-protected amino acid catalysis

2020 ◽  
Vol 56 (76) ◽  
pp. 11255-11258
Author(s):  
Bifu Liu ◽  
Wensen Ouyang ◽  
Jianhong Nie ◽  
Yang Gao ◽  
Kejun Feng ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Catalysis ◽  
Great Efficiency ◽  
Protected Amino Acid

By using mono-N-protected amino acid (MPAA) ligand under Pd(ii) catalysis, regioselective C–H alkynylation of weak coordinated nitrogen functionalities was developed with great efficiency, proceeding via 5, 6 and 7-membered palladacycle intermediates.

A facile one pot route for the synthesis of imide tethered peptidomimetics

2016 ◽  
Vol 14 (2) ◽  
pp. 556-563 ◽  
Author(s):  
Veladi Panduranga ◽  
Girish Prabhu ◽  
Roopesh Kumar ◽  
Basavaprabhu Basavaprabhu ◽  
Vommina V. Sureshbabu
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Efficient Method ◽  
One Pot ◽  
Protected Amino Acid

A simple and efficient method for the synthesis of N,N’-orthogonally protected imide tethered peptidomimetics is presented. The imide peptidomimetics were synthesized by coupling the in situ generated selenocarboxylate of Nα-protected amino acids with Nα-protected amino acid azides in good yields.

ChemInform Abstract: Urethane-Protected Amino Acid N-Carboxy Anhydrides and Their Use in Peptide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 22 (2) ◽  
pp. no-no
Author(s):  
W. D. FULLER ◽  
M. P. COHEN ◽  
M. SHABANKAREH ◽  
R. K. BLAIR ◽  
M. GOODMAN ◽  
...  
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Protected Amino Acid

Dynamic Kinetic Resolution of N-Protected Amino Acid Esters via Phase-Transfer Catalytic Base Hydrolysis

ACS Catalysis ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 5708-5713 ◽  
Author(s):  
Eiji Yamamoto ◽  
Kodai Wakafuji ◽  
Yuho Furutachi ◽  
Kaoru Kobayashi ◽  
Takashi Kamachi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Kinetic Resolution ◽  
Phase Transfer ◽  
Base Hydrolysis ◽  
Amino Acid Esters ◽  
Dynamic Kinetic Resolution ◽  
Protected Amino Acid ◽  
Acid Esters

Asymmetric Amino Acid Catalysis

2008 ◽  
Author(s):  
Armando Córdova ◽  
Enrique Díaz-Herrera ◽  
Eusebio Juaristi
Keyword(s):  
Amino Acid ◽  
Acid Catalysis
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