Facile synthesis of N-aryl phenothiazines and phenoxazines via Brønsted acid catalyzed C−H amination of arenes

2022 ◽  
Wang Xia ◽  
Zi-An Zhou ◽  
Jie Lv ◽  
Shao-Hua Xiang ◽  
Yong-Bin Wang ◽  

N-aryl phenothiazines and phenoxazines are of significant importance in various disciplines throughout academia and industry. Conventional synthetic strategy for the construction of these structures centers on transition-metal-catalyzed cross-coupling of aryl...

2018 ◽  
Vol 90 (4) ◽  
pp. 723-731 ◽  
Susanne Bähr ◽  
Martin Oestreich

AbstractSeveral approaches toward electrophilic C–H silylation of electron-rich arenes are discussed, comprising transition-metal-catalyzed processes as well as Lewis-acid- and Brønsted-acid-induced protocols. These methods differ in the catalytic generation of the silicon electrophile but share proton removal in form of dihydrogen. With slight modifications, these methods are often also applicable to the related electrophilic C–H borylation.

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85646-85651 ◽  
Guanshuo Shen ◽  
Haifeng Zhou ◽  
Peng Du ◽  
Sensheng Liu ◽  
Kun Zou ◽  

2013 ◽  
Vol 15 (6) ◽  
pp. 1266-1269 ◽  
Ghassan Qabaja ◽  
Jennifer E. Wilent ◽  
Amanda R. Benavides ◽  
George E. Bullard ◽  
Kimberly S. Petersen

2019 ◽  
Vol 55 (97) ◽  
pp. 14613-14616 ◽  
Kunhua Xu ◽  
Wenming Chen ◽  
Jin Lin ◽  
Guifang Chen ◽  
Biao Wang ◽  

A Brønsted acid system promotes the Friedel–Crafts alkenylation/1,6-addition/condensation cascade reaction of ynones with indoles to access 9H-pyrrolo[1,2-a]indoles.

Synlett ◽  
2022 ◽  
Long Li ◽  
Long-Wu Ye ◽  
Yao-Hong Yan

AbstractOver the past two decades, catalytic alkyne alkoxylation-initiated Claisen rearrangement has proven to be a practical and powerful strategy for the rapid assembly of a diverse range of structurally complex molecules. The rapid development of Claisen rearrangements triggered by transition-metal-catalyzed alkyne alkoxylation has shown great potential in the formation of carbon–carbon bonds in an atom-economic and mild way. However, metal-free alkyne alkoxylation-triggered Claisen rearrangement has seldom been exploited. Recently, Brønsted acids such as HNTf2 and HOTf have been shown to be powerful activators that promote catalytic alkyne alkoxylation/Claisen rearrangement, leading to the concise and flexible synthesis of valuable compounds with high efficiency and atom economy. Recent advances on the Brønsted acid catalyzed alkyne alkoxylation/Claisen rearrangement are introduced in this Account, in which both intramolecular and intermolecular tandem reactions are discussed.

2012 ◽  
Vol 355 (1) ◽  
pp. 87-92 ◽  
Ren-Lin Wang ◽  
Ping Zhu ◽  
Yu Lu ◽  
Fu-Ping Huang ◽  
Xin-Ping Hui

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