Synthesis of novel seven-membered carbasugars and evaluation of their glycosidase inhibition potentials

Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars have been synthesized from cyclic nitrones and assayed against various glycosidases.

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Diversity-Oriented Synthesis of cis-3,4-Dihydroxylated Piperidine and Its Higher Saturated and Unsaturated Homologues from d-Ribose and Their Glycosidase-Inhibition Study

Synlett ◽

10.1055/s-0036-1588310 ◽

2016 ◽

Vol 27 (19) ◽

pp. 2721-2725 ◽

Cited By ~ 3

Author(s):

Arun Shaw ◽

Sama Ajay ◽

Inderpreet Arora ◽

Puli Saidhareddy

Keyword(s):

Inhibition Study ◽

Diversity Oriented Synthesis ◽

Glycosidase Inhibition

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ChemInform Abstract: Synthesis of and Glycosidase Inhibition by α-L- Homofuconojirimycin.

ChemInform ◽

10.1002/chin.199427142 ◽

2010 ◽

Vol 25 (27) ◽

pp. no-no

Author(s):

D. M. ANDREWS ◽

M. I. BIRD ◽

M. M. CUNNINGHAM ◽

P. WARD

Keyword(s):

Glycosidase Inhibition

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Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro [3,2-b]pyridine motif

Carbohydrate Research ◽

10.1016/j.carres.2021.108491 ◽

2021 ◽

pp. 108491

Author(s):

Jérôme Désiré ◽

Quentin Foucart ◽

Ana Poveda ◽

Gurvan Gourlaouen ◽

Yuna Shimadate ◽

...

Keyword(s):

Conformational Analysis ◽

Glycosidase Inhibition

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Resveratrol-Related Polymethoxystilbene Glycosides: Synthesis, Antiproliferative Activity, and Glycosidase Inhibition

Journal of Natural Products ◽

10.1021/acs.jnatprod.5b00619 ◽

2015 ◽

Vol 78 (11) ◽

pp. 2675-2683 ◽

Cited By ~ 20

Author(s):

Nunzio Cardullo ◽

Carmela Spatafora ◽

Nicolò Musso ◽

Vincenza Barresi ◽

Daniele Condorelli ◽

...

Keyword(s):

Antiproliferative Activity ◽

Glycosidase Inhibition

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Design, synthesis and glycosidase inhibition studies of novel triazole fused iminocyclitol-δ-lactams

Organic & Biomolecular Chemistry ◽

10.1039/c8ob03084g ◽

2019 ◽

Vol 17 (5) ◽

pp. 1130-1140 ◽

Cited By ~ 7

Author(s):

Venkatesan Santhanam ◽

Pradeep Pant ◽

B. Jayaram ◽

Namakkal G. Ramesh

Keyword(s):

Design Synthesis ◽

Key Steps ◽

Inhibition Studies ◽

Glycosidase Inhibition

Synthesis of novel triazole fused iminocyclitol-δ-lactams, from tri-O-benzyl-d-glucal, involving intermolecular [3 + 2]cycloaddition and intramolecular lactamisation reactions as key steps is described.

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Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C-allyl iminosugar

Organic & Biomolecular Chemistry ◽

10.1039/c9ob01402k ◽

2019 ◽

Vol 17 (30) ◽

pp. 7204-7214 ◽

Cited By ~ 2

Author(s):

Quentin Foucart ◽

Yuna Shimadate ◽

Jérôme Marrot ◽

Atsushi Kato ◽

Jérôme Désiré ◽

...

Keyword(s):

Conformationally Locked ◽

Glycosidase Inhibition

The synthesis and glycosidase inhibition profile of a series of bicyclic analogs of DNJ and DMJ displaying a similar hydroxyl pattern and a distinct conformation is described.

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