Design, synthesis and glycosidase inhibition studies of novel triazole fused iminocyclitol-δ-lactams

2019 ◽  
Vol 17 (5) ◽  
pp. 1130-1140 ◽  
Author(s):  
Venkatesan Santhanam ◽  
Pradeep Pant ◽  
B. Jayaram ◽  
Namakkal G. Ramesh
Keyword(s):  
Design Synthesis ◽  
Key Steps ◽  
Inhibition Studies ◽  
Glycosidase Inhibition

Synthesis of novel triazole fused iminocyclitol-δ-lactams, from tri-O-benzyl-d-glucal, involving intermolecular [3 + 2]cycloaddition and intramolecular lactamisation reactions as key steps is described.

ChemInform Abstract: Design, Synthesis, and Urease Inhibition Studies of a Series of 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones.

ChemInform ◽  
2010 ◽  
Vol 41 (38) ◽  
pp. no-no
Author(s):  
Mahmood-ul-Hassan Khan ◽  
Shahid Hameed ◽  
Khawaja A. Yasin ◽  
Tashfeen Akhtar ◽  
Khalid M. Khan
Keyword(s):  
Urease Inhibition ◽  
Design Synthesis ◽  
Inhibition Studies

Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans

2013 ◽  
Vol 85 (7) ◽  
pp. 881-887 ◽  
Author(s):  
Cosimo D. Cadicamo ◽  
Jérémie Mortier ◽  
Gerhard Wolber ◽  
Marie Hell ◽  
Ina E. Heinrich ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Molecular Modeling ◽  
Aspartic Proteinases ◽  
Design Synthesis ◽  
Synthesis Inhibition ◽  
Inhibition Studies

Design, synthesis and biological evaluation as immunosuppressant of amino alcohol derivatives containing thioether

2021 ◽  
Vol 11 (5) ◽  
pp. 773-780
Author(s):  
Yanjie Li ◽  
Yongqiang Li ◽  
Liu Yang ◽  
Zhi Liu ◽  
Ruimeng Zhang ◽  
...  
Keyword(s):  
Amino Alcohol ◽  
Coupling Reaction ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Suzuki Coupling Reaction ◽  
Sphingosine 1 Phosphate ◽  
Potential Activity ◽  
Key Steps ◽  
Synthesis And Biological Evaluation

To develop a safer immunosuppressant for organ transplantation and autoimmune disease treatment, in this study, several of novel amino alcohol derivatives containing thioether moiety were synthesized with 7-bromo-tetralin-2-one as starting material, and Suzuki coupling reaction and Bucherer-Bergs reaction as key steps. Their activity as sphingosine 1-phosphate receptor type 1 (S1P1) agonists were evaluated by [γ-35S] GTP binding assay. Among the thioether substituted compounds, compound 10 showed good activity as S1P1 agonist at low micromolar concentration (EC50 = 0.698 μmol/L). The result suggested that it has potential activity against autoimmune diseases and immunosuppressant of organ transplantations.

ChemInform Abstract: Novel Acridinedione Derivatives: Design, Synthesis, SIRT1 Enzyme and Tumor Cell Growth Inhibition Studies.

ChemInform ◽  
2012 ◽  
Vol 43 (38) ◽  
pp. no-no
Author(s):  
Mallika Alvala ◽  
Shubhmita Bhatnagar ◽  
Alvala Ravi ◽  
Variam Ullas Jeankumar ◽  
Thimmappa H. Manjashetty ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition ◽  
Design Synthesis ◽  
Inhibition Studies

A New Access to Polyhydroxy Piperidines of the Azasugar Class: Synthesis and Glycosidase Inhibition Studies.

ChemInform ◽  
2004 ◽  
Vol 35 (8) ◽  
Author(s):  
Ganesh Pandey ◽  
Manmohan Kapur ◽  
M. Islam Khan ◽  
Sushama M. Gaikwad
Keyword(s):  
Inhibition Studies ◽  
Glycosidase Inhibition

Synthesis and Glycosidase Inhibition Studies of 5-Methyl-Substituted Tetrahydroxyindolizidines and -pyrrolizidines Related to Natural Hyacinthacines B

2013 ◽  
Vol 2013 (19) ◽  
pp. 4047-4056 ◽  
Author(s):  
Daniele Martella ◽  
Francesca Cardona ◽  
Camilla Parmeggiani ◽  
Francisco Franco ◽  
Juan A. Tamayo ◽  
...  
Keyword(s):  
Inhibition Studies ◽  
Glycosidase Inhibition

Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling & galectin-1 inhibition studies

2020 ◽  
Vol 102 ◽  
pp. 104125 ◽  
Author(s):  
Nerella Sridhar Goud ◽  
Venkatesh Pooladanda ◽  
K. Muni Chandra ◽  
P.S. Lakshmi Soukya ◽  
Ravi Alvala ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Design Synthesis ◽  
Apoptosis Inducing Agents ◽  
Inhibition Studies
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